Incisional or excisional neck-node biopsy before definitive radiotherapy, alone or followed by neck dissection
An analysis of 508 patients (660 heminecks) with head and neck squamous cell carcinoma and clinically positive neck nodes who were treated with radiotherapy alone to the primary lesion (with or without a neck dissection) was conducted to determine if open neck‐node biopsy before definitive treatment...
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| Veröffentlicht in: | Head & neck 1991-05, Vol.13 (3), p.177-183 |
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| container_title | Head & neck |
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| creator | Ellis, Eric R. Mendenhall, William M. Rao, P. V. McCarty, Patricia J. Parsons, James T. Stringer, Scott P. Cassisi, Nicholas J. Million, Rodney R. |
| description | An analysis of 508 patients (660 heminecks) with head and neck squamous cell carcinoma and clinically positive neck nodes who were treated with radiotherapy alone to the primary lesion (with or without a neck dissection) was conducted to determine if open neck‐node biopsy before definitive treatment adversely affected the probability of control of neck disease, the risk of distant metastasis, or the cause‐specific survival rate. The prognostic factors analyzed included biopsy status of the neck, N stage, neck treatment, node mobility, node location, T stage, primary site, and control of disease above the clavicles. Sixty‐six patients who had undergone an open neck‐node biopsy before definitive radiotherapy were compared with a control group of 442 patients who did not undergo a neck‐node biopsy; no detrimental effect of the biopsy on neck control, distant metastasis, or cause‐specific survival was demonstrated. We conclude that the potential adverse effect of violating the neck before definitive treatment cannot be demonstrated if radiotherapy is the next step in the patient's management. |
| doi_str_mv | 10.1002/hed.2880130303 |
| format | Article |
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V. ; McCarty, Patricia J. ; Parsons, James T. ; Stringer, Scott P. ; Cassisi, Nicholas J. ; Million, Rodney R.</creator><creatorcontrib>Ellis, Eric R. ; Mendenhall, William M. ; Rao, P. V. ; McCarty, Patricia J. ; Parsons, James T. ; Stringer, Scott P. ; Cassisi, Nicholas J. ; Million, Rodney R.</creatorcontrib><description>An analysis of 508 patients (660 heminecks) with head and neck squamous cell carcinoma and clinically positive neck nodes who were treated with radiotherapy alone to the primary lesion (with or without a neck dissection) was conducted to determine if open neck‐node biopsy before definitive treatment adversely affected the probability of control of neck disease, the risk of distant metastasis, or the cause‐specific survival rate. The prognostic factors analyzed included biopsy status of the neck, N stage, neck treatment, node mobility, node location, T stage, primary site, and control of disease above the clavicles. Sixty‐six patients who had undergone an open neck‐node biopsy before definitive radiotherapy were compared with a control group of 442 patients who did not undergo a neck‐node biopsy; no detrimental effect of the biopsy on neck control, distant metastasis, or cause‐specific survival was demonstrated. We conclude that the potential adverse effect of violating the neck before definitive treatment cannot be demonstrated if radiotherapy is the next step in the patient's management.</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.2880130303</identifier><identifier>PMID: 2037468</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Biological and medical sciences ; Biopsy ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - prevention & control ; Carcinoma, Squamous Cell - radiotherapy ; Carcinoma, Squamous Cell - secondary ; Carcinoma, Squamous Cell - surgery ; Follow-Up Studies ; Head and Neck Neoplasms - pathology ; Head and Neck Neoplasms - prevention & control ; Head and Neck Neoplasms - radiotherapy ; Head and Neck Neoplasms - surgery ; Humans ; Lymph Node Excision ; Lymph Nodes - pathology ; Lymph Nodes - surgery ; Medical sciences ; Multivariate Analysis ; Neck ; Neoplasm Recurrence, Local - prevention & control ; Neoplasm Seeding ; Neoplasm Staging ; Otorhinolaryngology (head neck, general aspects and miscellaneous) ; Otorhinolaryngology. Stomatology ; Prognosis ; Regression Analysis ; Survival Rate ; Tumors</subject><ispartof>Head & neck, 1991-05, Vol.13 (3), p.177-183</ispartof><rights>Copyright © 1991 Wiley Periodicals, Inc., A Wiley Company</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4083-e8035c30354f64c09e114911a396e734527c552104f3b69066631f7c17f33a583</citedby><cites>FETCH-LOGICAL-c4083-e8035c30354f64c09e114911a396e734527c552104f3b69066631f7c17f33a583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.2880130303$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.2880130303$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,1417,23930,23931,25140,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19739449$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2037468$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ellis, Eric R.</creatorcontrib><creatorcontrib>Mendenhall, William M.</creatorcontrib><creatorcontrib>Rao, P. V.</creatorcontrib><creatorcontrib>McCarty, Patricia J.</creatorcontrib><creatorcontrib>Parsons, James T.</creatorcontrib><creatorcontrib>Stringer, Scott P.</creatorcontrib><creatorcontrib>Cassisi, Nicholas J.</creatorcontrib><creatorcontrib>Million, Rodney R.</creatorcontrib><title>Incisional or excisional neck-node biopsy before definitive radiotherapy, alone or followed by neck dissection</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>An analysis of 508 patients (660 heminecks) with head and neck squamous cell carcinoma and clinically positive neck nodes who were treated with radiotherapy alone to the primary lesion (with or without a neck dissection) was conducted to determine if open neck‐node biopsy before definitive treatment adversely affected the probability of control of neck disease, the risk of distant metastasis, or the cause‐specific survival rate. The prognostic factors analyzed included biopsy status of the neck, N stage, neck treatment, node mobility, node location, T stage, primary site, and control of disease above the clavicles. Sixty‐six patients who had undergone an open neck‐node biopsy before definitive radiotherapy were compared with a control group of 442 patients who did not undergo a neck‐node biopsy; no detrimental effect of the biopsy on neck control, distant metastasis, or cause‐specific survival was demonstrated. We conclude that the potential adverse effect of violating the neck before definitive treatment cannot be demonstrated if radiotherapy is the next step in the patient's management.</description><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - prevention & control</subject><subject>Carcinoma, Squamous Cell - radiotherapy</subject><subject>Carcinoma, Squamous Cell - secondary</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Follow-Up Studies</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>Head and Neck Neoplasms - prevention & control</subject><subject>Head and Neck Neoplasms - radiotherapy</subject><subject>Head and Neck Neoplasms - surgery</subject><subject>Humans</subject><subject>Lymph Node Excision</subject><subject>Lymph Nodes - pathology</subject><subject>Lymph Nodes - surgery</subject><subject>Medical sciences</subject><subject>Multivariate Analysis</subject><subject>Neck</subject><subject>Neoplasm Recurrence, Local - prevention & control</subject><subject>Neoplasm Seeding</subject><subject>Neoplasm Staging</subject><subject>Otorhinolaryngology (head neck, general aspects and miscellaneous)</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Prognosis</subject><subject>Regression Analysis</subject><subject>Survival Rate</subject><subject>Tumors</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1vFSEUxYnR1FrdujOZja6c52VgYFia2q-k8Su1LgnDXFIsb3iFeW3nv5fne7ZxZVgAOef84B5CXlNYUIDmwxUOi6brgDIo6wnZp6BkDYzLp5szZzUDyZ-TFzn_AgAmeLNH9hpgkotun4xno_XZx9GEKqYK7x9uI9rreowDVr2PqzxXPbqYsBrQ-dFP_harZAYfpytMZjW_r0yII24gLoYQ73Co-vkPpRp8zminwn1JnjkTMr7a7Qfkx_HRxeFpff7l5Ozw43ltOXSsxg5Ya8s8LXeCW1BIKVeUGqYESsbbRtq2bcp4jvVCgRCCUSctlY4x03bsgLzbclcp3qwxT3rps8UQzIhxnXUHbUcb2RTjYmu0Keac0OlV8kuTZk1BbwrWpWD9WHAJvNmR1_2ySH_tu0aL_nanm2xNcMlsCn6kKskU56r41NZ35wPO_3lVnx59-ucP9Tbr84T3D1mTrrWQTLb65-cTLfm3r5cX30Ffst8aAKKA</recordid><startdate>199105</startdate><enddate>199105</enddate><creator>Ellis, Eric R.</creator><creator>Mendenhall, William M.</creator><creator>Rao, P. 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V. ; McCarty, Patricia J. ; Parsons, James T. ; Stringer, Scott P. ; Cassisi, Nicholas J. ; Million, Rodney R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4083-e8035c30354f64c09e114911a396e734527c552104f3b69066631f7c17f33a583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - prevention & control</topic><topic>Carcinoma, Squamous Cell - radiotherapy</topic><topic>Carcinoma, Squamous Cell - secondary</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>Follow-Up Studies</topic><topic>Head and Neck Neoplasms - pathology</topic><topic>Head and Neck Neoplasms - prevention & control</topic><topic>Head and Neck Neoplasms - radiotherapy</topic><topic>Head and Neck Neoplasms - surgery</topic><topic>Humans</topic><topic>Lymph Node Excision</topic><topic>Lymph Nodes - pathology</topic><topic>Lymph Nodes - surgery</topic><topic>Medical sciences</topic><topic>Multivariate Analysis</topic><topic>Neck</topic><topic>Neoplasm Recurrence, Local - prevention & control</topic><topic>Neoplasm Seeding</topic><topic>Neoplasm Staging</topic><topic>Otorhinolaryngology (head neck, general aspects and miscellaneous)</topic><topic>Otorhinolaryngology. 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| ispartof | Head & neck, 1991-05, Vol.13 (3), p.177-183 |
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| language | eng |
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| subjects | Biological and medical sciences Biopsy Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - prevention & control Carcinoma, Squamous Cell - radiotherapy Carcinoma, Squamous Cell - secondary Carcinoma, Squamous Cell - surgery Follow-Up Studies Head and Neck Neoplasms - pathology Head and Neck Neoplasms - prevention & control Head and Neck Neoplasms - radiotherapy Head and Neck Neoplasms - surgery Humans Lymph Node Excision Lymph Nodes - pathology Lymph Nodes - surgery Medical sciences Multivariate Analysis Neck Neoplasm Recurrence, Local - prevention & control Neoplasm Seeding Neoplasm Staging Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Prognosis Regression Analysis Survival Rate Tumors |
| title | Incisional or excisional neck-node biopsy before definitive radiotherapy, alone or followed by neck dissection |
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