MILBEMYCINS, A NEW FAMILY OF MACROLIDE ANTIBIOTICS: FERMENTATION, ISOLATION AND PHYSICO-CHEMICAL PROPERTIES OF MILBEMYCINS D, E, F, G AND H

Strain Au-3, a mutant of Streptomyces hygroscopicussubsp. aureolacrimosus, obtained with ultraviolet irradiation, was a high-yield strain of milbemycins D, E, F, G and H. Fermentation studies on the strains were conducted in shake flasks and 30-liter jar fermentors. Isolation of the metabolites was...

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Veröffentlicht in:	Journal of antibiotics 1983, Vol.36(5), pp.502-508
Hauptverfasser:	TAKIGUCHI, YO, ONO, MICHIHISA, MURAMATSU, SHIGEKI, IDE, JUNYA, MISHIMA, HIROSHI, TERAO, MICHIYA
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents Chemical Phenomena Chemistry Fermentation Lactones - isolation & purification Lactones - metabolism Macrolides Streptomyces - metabolism
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