Genetic Regulation of GM2 Expression in Liver of Mouse
GM2 containing NeuGc was found to be a major ganglioside in the liver of most inbred strains of mouse we have examined so far. They were DBA/2, C3H/He, C57BL/6, BALB/c, and CBA mice. However, WHT/Ht mouse does not contain a detectable amount of GM2 (NeuGc) but has GM3 containing NeuGc as the major g...
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| Veröffentlicht in: | Journal of biochemistry (Tokyo) 1983-03, Vol.93 (3), p.895-901 |
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| container_title | Journal of biochemistry (Tokyo) |
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| creator | HASHIMOTO, Yasuhiro OTSUKA, Hideaki SUDO, Katsuko SUZUKI, Kiyoshi SUZUKI, Akemi YAMAKAWA, Tamio |
| description | GM2 containing NeuGc was found to be a major ganglioside in the liver of most inbred strains of mouse we have examined so far. They were DBA/2, C3H/He, C57BL/6, BALB/c, and CBA mice. However, WHT/Ht mouse does not contain a detectable amount of GM2 (NeuGc) but has GM3 containing NeuGc as the major ganglioside in the liver. The positive expression of GM2 (NeuGc) was demonstrated in the liver of F1 hybrids between WHT/Ht and DBA/2 mice, as one of the possible combinations. Moreover, the expression of GM2 (NeuGc) in the liver was proved to be an autosomal dominant trait by ganglioside analysis of 34 individual mice of the F2 and backcross generations. WHT/Ht mouse was demon strated to be a recessive homozygote lacking GM2 (NeuGc) expression. During the analysis, interestingly enough, the enhanced elongation of the sugar chain in the gangliosides from GM2 (NeuGc) to GM1 (NeuGc) and GDI was observed in the liver of F1 mice and this elongation was segregated only in half members of F2 and backcross generations. |
| doi_str_mv | 10.1093/jb/93.3.895 |
| format | Article |
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They were DBA/2, C3H/He, C57BL/6, BALB/c, and CBA mice. However, WHT/Ht mouse does not contain a detectable amount of GM2 (NeuGc) but has GM3 containing NeuGc as the major ganglioside in the liver. The positive expression of GM2 (NeuGc) was demonstrated in the liver of F1 hybrids between WHT/Ht and DBA/2 mice, as one of the possible combinations. Moreover, the expression of GM2 (NeuGc) in the liver was proved to be an autosomal dominant trait by ganglioside analysis of 34 individual mice of the F2 and backcross generations. WHT/Ht mouse was demon strated to be a recessive homozygote lacking GM2 (NeuGc) expression. During the analysis, interestingly enough, the enhanced elongation of the sugar chain in the gangliosides from GM2 (NeuGc) to GM1 (NeuGc) and GDI was observed in the liver of F1 mice and this elongation was segregated only in half members of F2 and backcross generations.</description><identifier>ISSN: 0021-924X</identifier><identifier>EISSN: 1756-2651</identifier><identifier>DOI: 10.1093/jb/93.3.895</identifier><identifier>PMID: 6874670</identifier><identifier>CODEN: JOBIAO</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Analytical, structural and metabolic biochemistry ; Animals ; Biological and medical sciences ; Chromatography, Thin Layer ; Crosses, Genetic ; Female ; Fundamental and applied biological sciences. Psychology ; G(M2) Ganglioside - genetics ; G(M2) Ganglioside - metabolism ; Gangliosides - metabolism ; Gene Expression Regulation ; Lipids ; Liver - metabolism ; Male ; Mice ; Mice, Inbred DBA ; Mice, Inbred Strains ; Other biological molecules</subject><ispartof>Journal of biochemistry (Tokyo), 1983-03, Vol.93 (3), p.895-901</ispartof><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c574t-f3fc184d31a58802d05ac8b63c67be2c05d6a5c07ed54b3d9713e411d42862513</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9587721$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6874670$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HASHIMOTO, Yasuhiro</creatorcontrib><creatorcontrib>OTSUKA, Hideaki</creatorcontrib><creatorcontrib>SUDO, Katsuko</creatorcontrib><creatorcontrib>SUZUKI, Kiyoshi</creatorcontrib><creatorcontrib>SUZUKI, Akemi</creatorcontrib><creatorcontrib>YAMAKAWA, Tamio</creatorcontrib><title>Genetic Regulation of GM2 Expression in Liver of Mouse</title><title>Journal of biochemistry (Tokyo)</title><addtitle>J Biochem</addtitle><description>GM2 containing NeuGc was found to be a major ganglioside in the liver of most inbred strains of mouse we have examined so far. They were DBA/2, C3H/He, C57BL/6, BALB/c, and CBA mice. However, WHT/Ht mouse does not contain a detectable amount of GM2 (NeuGc) but has GM3 containing NeuGc as the major ganglioside in the liver. The positive expression of GM2 (NeuGc) was demonstrated in the liver of F1 hybrids between WHT/Ht and DBA/2 mice, as one of the possible combinations. Moreover, the expression of GM2 (NeuGc) in the liver was proved to be an autosomal dominant trait by ganglioside analysis of 34 individual mice of the F2 and backcross generations. WHT/Ht mouse was demon strated to be a recessive homozygote lacking GM2 (NeuGc) expression. During the analysis, interestingly enough, the enhanced elongation of the sugar chain in the gangliosides from GM2 (NeuGc) to GM1 (NeuGc) and GDI was observed in the liver of F1 mice and this elongation was segregated only in half members of F2 and backcross generations.</description><subject>Analytical, structural and metabolic biochemistry</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chromatography, Thin Layer</subject><subject>Crosses, Genetic</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>G(M2) Ganglioside - genetics</subject><subject>G(M2) Ganglioside - metabolism</subject><subject>Gangliosides - metabolism</subject><subject>Gene Expression Regulation</subject><subject>Lipids</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred DBA</subject><subject>Mice, Inbred Strains</subject><subject>Other biological molecules</subject><issn>0021-924X</issn><issn>1756-2651</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtLw0AQxhdRaq2ePAs5iBdJu4_sI0cJtRVbxBcUL8tms5GtaVJ3E6n_vQkNvXqZYeb78THzAXCJ4BjBmEzW6SQmYzIWMT0CQ8QpCzGj6BgMIcQojHG0OgVn3q-7ERMyAAMmeMQ4HAI2M6WprQ5ezGdTqNpWZVDlwWyJg-lu64z33caWwcL-GNdJy6rx5hyc5Krw5qLvI_B-P31L5uHiafaQ3C1CTXlUhznJNRJRRpCiQkCcQaq0SBnRjKcGa0gzpqiG3GQ0SkkWc0RMhFAWYcEwRWQEbva-W1d9N8bXcmO9NkWhStPeIQWknMWI_AsiwjCPeQfe7kHtKu-dyeXW2Y1yvxJB2cUp16lsK5FtnC191ds26cZkB7bPr9Wve115rYrcqVJbf8BiKjjH3RvhHrO-NruDrNyXZJxwKuerD_k8T16TRwjlivwBQnuJbw</recordid><startdate>198303</startdate><enddate>198303</enddate><creator>HASHIMOTO, Yasuhiro</creator><creator>OTSUKA, Hideaki</creator><creator>SUDO, Katsuko</creator><creator>SUZUKI, Kiyoshi</creator><creator>SUZUKI, Akemi</creator><creator>YAMAKAWA, Tamio</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>198303</creationdate><title>Genetic Regulation of GM2 Expression in Liver of Mouse</title><author>HASHIMOTO, Yasuhiro ; OTSUKA, Hideaki ; SUDO, Katsuko ; SUZUKI, Kiyoshi ; SUZUKI, Akemi ; YAMAKAWA, Tamio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c574t-f3fc184d31a58802d05ac8b63c67be2c05d6a5c07ed54b3d9713e411d42862513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Analytical, structural and metabolic biochemistry</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chromatography, Thin Layer</topic><topic>Crosses, Genetic</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>G(M2) Ganglioside - genetics</topic><topic>G(M2) Ganglioside - metabolism</topic><topic>Gangliosides - metabolism</topic><topic>Gene Expression Regulation</topic><topic>Lipids</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred DBA</topic><topic>Mice, Inbred Strains</topic><topic>Other biological molecules</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HASHIMOTO, Yasuhiro</creatorcontrib><creatorcontrib>OTSUKA, Hideaki</creatorcontrib><creatorcontrib>SUDO, Katsuko</creatorcontrib><creatorcontrib>SUZUKI, Kiyoshi</creatorcontrib><creatorcontrib>SUZUKI, Akemi</creatorcontrib><creatorcontrib>YAMAKAWA, Tamio</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biochemistry (Tokyo)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HASHIMOTO, Yasuhiro</au><au>OTSUKA, Hideaki</au><au>SUDO, Katsuko</au><au>SUZUKI, Kiyoshi</au><au>SUZUKI, Akemi</au><au>YAMAKAWA, Tamio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic Regulation of GM2 Expression in Liver of Mouse</atitle><jtitle>Journal of biochemistry (Tokyo)</jtitle><addtitle>J Biochem</addtitle><date>1983-03</date><risdate>1983</risdate><volume>93</volume><issue>3</issue><spage>895</spage><epage>901</epage><pages>895-901</pages><issn>0021-924X</issn><eissn>1756-2651</eissn><coden>JOBIAO</coden><abstract>GM2 containing NeuGc was found to be a major ganglioside in the liver of most inbred strains of mouse we have examined so far. They were DBA/2, C3H/He, C57BL/6, BALB/c, and CBA mice. However, WHT/Ht mouse does not contain a detectable amount of GM2 (NeuGc) but has GM3 containing NeuGc as the major ganglioside in the liver. The positive expression of GM2 (NeuGc) was demonstrated in the liver of F1 hybrids between WHT/Ht and DBA/2 mice, as one of the possible combinations. Moreover, the expression of GM2 (NeuGc) in the liver was proved to be an autosomal dominant trait by ganglioside analysis of 34 individual mice of the F2 and backcross generations. WHT/Ht mouse was demon strated to be a recessive homozygote lacking GM2 (NeuGc) expression. During the analysis, interestingly enough, the enhanced elongation of the sugar chain in the gangliosides from GM2 (NeuGc) to GM1 (NeuGc) and GDI was observed in the liver of F1 mice and this elongation was segregated only in half members of F2 and backcross generations.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>6874670</pmid><doi>10.1093/jb/93.3.895</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of biochemistry (Tokyo), 1983-03, Vol.93 (3), p.895-901 |
| issn | 0021-924X 1756-2651 |
| language | eng |
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| source | J-STAGE Free; MEDLINE; Oxford University Press Journals Digital Archive Legacy; Free Full-Text Journals in Chemistry |
| subjects | Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Chromatography, Thin Layer Crosses, Genetic Female Fundamental and applied biological sciences. Psychology G(M2) Ganglioside - genetics G(M2) Ganglioside - metabolism Gangliosides - metabolism Gene Expression Regulation Lipids Liver - metabolism Male Mice Mice, Inbred DBA Mice, Inbred Strains Other biological molecules |
| title | Genetic Regulation of GM2 Expression in Liver of Mouse |
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