Characterization of a precipitating antigen detected in the serum of patients with viral hepatitis
During a search for the aetiological agent of non‐A non‐B hepatitis, a precipitating antigen was detected in the sera of some patients during the acute phase of their illness. The antigen was detected by agar gel diffusion using antibody from convalcscent sera obtained from patients with non‐A non‐B...
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| Veröffentlicht in: | Journal of medical virology 1983, Vol.11 (4), p.267-276 |
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| container_issue | 4 |
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| container_title | Journal of medical virology |
| container_volume | 11 |
| creator | Zhuang, Hui Coulepis, Anthony G. Locarnini, Stephen A. Marshall, John A. Gust, Ian D. Kaldor, Jakov |
| description | During a search for the aetiological agent of non‐A non‐B hepatitis, a precipitating antigen was detected in the sera of some patients during the acute phase of their illness. The antigen was detected by agar gel diffusion using antibody from convalcscent sera obtained from patients with non‐A non‐B hepatitis, and from haemophiliac sera. The antigen was usually detected early in the patient's illness, disappearing as liver function tests returned to normal. In some patients specific antibody appeared during the convalescent phase of the disease. The antigen does not appear to be specific for non‐A non‐B hepatitis, as it could be detected with similar frequency in patients with hepatitis A or hepatitis B and some patients with other liver disorders. Biochemical and biophysical studies suggest that the antigen is probably an abnormal lipoprotein produced as a result of acute liver damage. |
| doi_str_mv | 10.1002/jmv.1890110402 |
| format | Article |
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The antigen was detected by agar gel diffusion using antibody from convalcscent sera obtained from patients with non‐A non‐B hepatitis, and from haemophiliac sera. The antigen was usually detected early in the patient's illness, disappearing as liver function tests returned to normal. In some patients specific antibody appeared during the convalescent phase of the disease. The antigen does not appear to be specific for non‐A non‐B hepatitis, as it could be detected with similar frequency in patients with hepatitis A or hepatitis B and some patients with other liver disorders. Biochemical and biophysical studies suggest that the antigen is probably an abnormal lipoprotein produced as a result of acute liver damage.</description><identifier>ISSN: 0146-6615</identifier><identifier>EISSN: 1096-9071</identifier><identifier>DOI: 10.1002/jmv.1890110402</identifier><identifier>PMID: 6409994</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Antigens - analysis ; Hemophilia A - immunology ; Hepatitis A - immunology ; Hepatitis B - immunology ; Hepatitis C - immunology ; Hepatitis, Viral, Human - immunology ; Humans ; Immunodiffusion ; lipoprotein ; Liver Diseases - immunology ; non-A non-B hepatitis ; Precipitin Tests ; Time Factors ; viral hepatitis</subject><ispartof>Journal of medical virology, 1983, Vol.11 (4), p.267-276</ispartof><rights>Copyright © 1983 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3332-6d0b39ae8f54d53b8dde080e73fbfc3787fc1e08533335283fe0017b665ca11c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmv.1890110402$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmv.1890110402$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,4010,27900,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6409994$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhuang, Hui</creatorcontrib><creatorcontrib>Coulepis, Anthony G.</creatorcontrib><creatorcontrib>Locarnini, Stephen A.</creatorcontrib><creatorcontrib>Marshall, John A.</creatorcontrib><creatorcontrib>Gust, Ian D.</creatorcontrib><creatorcontrib>Kaldor, Jakov</creatorcontrib><title>Characterization of a precipitating antigen detected in the serum of patients with viral hepatitis</title><title>Journal of medical virology</title><addtitle>J. Med. Virol</addtitle><description>During a search for the aetiological agent of non‐A non‐B hepatitis, a precipitating antigen was detected in the sera of some patients during the acute phase of their illness. The antigen was detected by agar gel diffusion using antibody from convalcscent sera obtained from patients with non‐A non‐B hepatitis, and from haemophiliac sera. The antigen was usually detected early in the patient's illness, disappearing as liver function tests returned to normal. In some patients specific antibody appeared during the convalescent phase of the disease. The antigen does not appear to be specific for non‐A non‐B hepatitis, as it could be detected with similar frequency in patients with hepatitis A or hepatitis B and some patients with other liver disorders. Biochemical and biophysical studies suggest that the antigen is probably an abnormal lipoprotein produced as a result of acute liver damage.</description><subject>Antigens - analysis</subject><subject>Hemophilia A - immunology</subject><subject>Hepatitis A - immunology</subject><subject>Hepatitis B - immunology</subject><subject>Hepatitis C - immunology</subject><subject>Hepatitis, Viral, Human - immunology</subject><subject>Humans</subject><subject>Immunodiffusion</subject><subject>lipoprotein</subject><subject>Liver Diseases - immunology</subject><subject>non-A non-B hepatitis</subject><subject>Precipitin Tests</subject><subject>Time Factors</subject><subject>viral hepatitis</subject><issn>0146-6615</issn><issn>1096-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDtvFDEUhS0ECptAS4fkim6W6_GMHyVakZAoCSl4KY3l8dzJOswL25sHvx6vdhVERXWlc7_zFYeQNwyWDKB8fzvcLZnSwBhUUD4jCwZaFBoke04WwCpRCMHql-QwxlsAULosD8iBqEBrXS1Is1rbYF3C4H_b5KeRTh21dA7o_OxTjsYbasfkb3CkLSbMaEv9SNMaacSwGbaFOXM4pkjvfVrTOx9sT9e4TZOPr8iLzvYRX-_vEfl6_PHL6lNx_vnkdPXhvHCc87IQLTRcW1RdXbU1b1TbIihAybumc1wq2TmWkzrTvC4V7xCAyUaI2lnGHD8i73beOUy_NhiTGXx02Pd2xGkTjYJaVkzxDC53oAtTjAE7Mwc_2PBoGJjtqCaPav6Omgtv9-ZNM2D7hO9XzH-9-9_7Hh__YzNnF9_-cRe7ro8JH566Nvw0QnJZm--XJ-b4Sq749fWV-cH_AG_Dk7w</recordid><startdate>1983</startdate><enddate>1983</enddate><creator>Zhuang, Hui</creator><creator>Coulepis, Anthony G.</creator><creator>Locarnini, Stephen A.</creator><creator>Marshall, John A.</creator><creator>Gust, Ian D.</creator><creator>Kaldor, Jakov</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1983</creationdate><title>Characterization of a precipitating antigen detected in the serum of patients with viral hepatitis</title><author>Zhuang, Hui ; Coulepis, Anthony G. ; Locarnini, Stephen A. ; Marshall, John A. ; Gust, Ian D. ; Kaldor, Jakov</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3332-6d0b39ae8f54d53b8dde080e73fbfc3787fc1e08533335283fe0017b665ca11c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Antigens - analysis</topic><topic>Hemophilia A - immunology</topic><topic>Hepatitis A - immunology</topic><topic>Hepatitis B - immunology</topic><topic>Hepatitis C - immunology</topic><topic>Hepatitis, Viral, Human - immunology</topic><topic>Humans</topic><topic>Immunodiffusion</topic><topic>lipoprotein</topic><topic>Liver Diseases - immunology</topic><topic>non-A non-B hepatitis</topic><topic>Precipitin Tests</topic><topic>Time Factors</topic><topic>viral hepatitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhuang, Hui</creatorcontrib><creatorcontrib>Coulepis, Anthony G.</creatorcontrib><creatorcontrib>Locarnini, Stephen A.</creatorcontrib><creatorcontrib>Marshall, John A.</creatorcontrib><creatorcontrib>Gust, Ian D.</creatorcontrib><creatorcontrib>Kaldor, Jakov</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhuang, Hui</au><au>Coulepis, Anthony G.</au><au>Locarnini, Stephen A.</au><au>Marshall, John A.</au><au>Gust, Ian D.</au><au>Kaldor, Jakov</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of a precipitating antigen detected in the serum of patients with viral hepatitis</atitle><jtitle>Journal of medical virology</jtitle><addtitle>J. Med. Virol</addtitle><date>1983</date><risdate>1983</risdate><volume>11</volume><issue>4</issue><spage>267</spage><epage>276</epage><pages>267-276</pages><issn>0146-6615</issn><eissn>1096-9071</eissn><abstract>During a search for the aetiological agent of non‐A non‐B hepatitis, a precipitating antigen was detected in the sera of some patients during the acute phase of their illness. The antigen was detected by agar gel diffusion using antibody from convalcscent sera obtained from patients with non‐A non‐B hepatitis, and from haemophiliac sera. The antigen was usually detected early in the patient's illness, disappearing as liver function tests returned to normal. In some patients specific antibody appeared during the convalescent phase of the disease. The antigen does not appear to be specific for non‐A non‐B hepatitis, as it could be detected with similar frequency in patients with hepatitis A or hepatitis B and some patients with other liver disorders. Biochemical and biophysical studies suggest that the antigen is probably an abnormal lipoprotein produced as a result of acute liver damage.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>6409994</pmid><doi>10.1002/jmv.1890110402</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0146-6615 |
| ispartof | Journal of medical virology, 1983, Vol.11 (4), p.267-276 |
| issn | 0146-6615 1096-9071 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80574183 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Antigens - analysis Hemophilia A - immunology Hepatitis A - immunology Hepatitis B - immunology Hepatitis C - immunology Hepatitis, Viral, Human - immunology Humans Immunodiffusion lipoprotein Liver Diseases - immunology non-A non-B hepatitis Precipitin Tests Time Factors viral hepatitis |
| title | Characterization of a precipitating antigen detected in the serum of patients with viral hepatitis |
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