Use of the deoxyuridine suppression test to evaluate localized folate deficiency in rat colonic epithelium

In this study the deoxyuridine suppression test (dUST) was performed on isolated rat colonocytes to establish its value as an indicator of folate status in the colonic epithelium. [3H]thymidine incorporation into DNA was suppressed < 90% by deoxyuridine (dU) concentrations < 2.5 µmol/L. Preinc...

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Veröffentlicht in:	The American journal of clinical nutrition 1991-06, Vol.53 (6), p.1450-1454
Hauptverfasser:	Cravo, ML, Mason, JB, Selhub, J, Rosenberg, IH
Format:	Artikel
Sprache:	eng
Schlagworte:	5-fluorouracil ACIDE FOLIQUE ACIDO FOLICO Animals ANTIVITAMINAS ANTIVITAMINE Biological and medical sciences CARENCE EN VITAMINE Cells, Cultured Colon - chemistry Colon - cytology DEFICIENCIA DE VITAMINAS DEOXYRIBONUCLEOSIDE Deoxyuridine deoxyuridine suppression test DESOXIRIBONUCLEOSIDOS DNA - metabolism EPITELIO EPITHELIUM Epithelium - chemistry FLUOROURACIL Fluorouracil - metabolism FLUOROURACILE Folate folate deficiency folic acid Folic Acid - analysis INTESTIN INTESTINOS Investigative techniques, diagnostic techniques (general aspects) localized folate deficiency Male Medical sciences Metabolic diseases methotrexate Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques RAT rat colonocytes RATA Rats Rats, Inbred Strains THYMIDINE Thymidine - metabolism TIMIDINA
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