Fasting and Postprandial Plasma Glucagon and Glucagon-Like Immunoreactivity are Normal in Obese Pima Indians
Summary Glucose, insulin (IRI), glucagon (IRG) and GLI were measured in plasma samples obtained from 32 subjects representing a wide range of body weight (body mass index = 21-49 kg/m 2 ) after an overnight fast and for 6 hr following ingestion of a standard test meal. The 6 hr integrated postprandi...
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| Veröffentlicht in: | Hormone and metabolic research 1983-05, Vol.15 (5), p.218-220 |
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| container_title | Hormone and metabolic research |
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| creator | Vasquez, Barbara Nagulesparan, M. Unger, R. H. |
| description | Summary
Glucose, insulin (IRI), glucagon (IRG) and GLI were measured in plasma samples obtained from 32 subjects representing a wide range of body weight (body mass index = 21-49 kg/m
2
) after an overnight fast and for 6 hr following ingestion of a standard test meal. The 6 hr integrated postprandial response of each hormone was estimated for each subject from the area of the response curve above basal concentration. Both fasting (r = 0.72, p < 0.0001) and postprandial (r = 0.45, p < 0.01) IRI were significantly correlated with degree of obesity, as expected. However, the fasting and postprandial plasma glucagon and glucagon-like immunoreactivity levels were not related to obesity of the subject and were not different for the obese (BMI > 35, n = 16) and nonobese (BMI < 30, n = 12) groups. Thus, there is no evidence for an abnormality in the response of these peptide hormones to a mixed meal in this obese population. |
| doi_str_mv | 10.1055/s-2007-1018676 |
| format | Article |
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Glucose, insulin (IRI), glucagon (IRG) and GLI were measured in plasma samples obtained from 32 subjects representing a wide range of body weight (body mass index = 21-49 kg/m
2
) after an overnight fast and for 6 hr following ingestion of a standard test meal. The 6 hr integrated postprandial response of each hormone was estimated for each subject from the area of the response curve above basal concentration. Both fasting (r = 0.72, p < 0.0001) and postprandial (r = 0.45, p < 0.01) IRI were significantly correlated with degree of obesity, as expected. However, the fasting and postprandial plasma glucagon and glucagon-like immunoreactivity levels were not related to obesity of the subject and were not different for the obese (BMI > 35, n = 16) and nonobese (BMI < 30, n = 12) groups. Thus, there is no evidence for an abnormality in the response of these peptide hormones to a mixed meal in this obese population.</description><identifier>ISSN: 0018-5043</identifier><identifier>EISSN: 1439-4286</identifier><identifier>DOI: 10.1055/s-2007-1018676</identifier><identifier>PMID: 6347855</identifier><language>eng</language><publisher>Germany</publisher><subject>Adult ; Blood Glucose - analysis ; Fasting ; Food ; Glucagon - blood ; Glucagon-Like Peptides ; Humans ; Indians, North American ; Insulin - blood ; Middle Aged ; Obesity - blood ; Originals ; Peptides - blood</subject><ispartof>Hormone and metabolic research, 1983-05, Vol.15 (5), p.218-220</ispartof><rights>Georg Thieme Verlag, Stuttgart · New York</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c328t-ebdb41234744906c325314ee0eff71e1a2ed905a8ca70ecf36313938bc0718113</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2007-1018676.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><link.rule.ids>314,776,780,3004,3005,27901,27902,54534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6347855$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vasquez, Barbara</creatorcontrib><creatorcontrib>Nagulesparan, M.</creatorcontrib><creatorcontrib>Unger, R. H.</creatorcontrib><title>Fasting and Postprandial Plasma Glucagon and Glucagon-Like Immunoreactivity are Normal in Obese Pima Indians</title><title>Hormone and metabolic research</title><addtitle>Horm Metab Res</addtitle><description>Summary
Glucose, insulin (IRI), glucagon (IRG) and GLI were measured in plasma samples obtained from 32 subjects representing a wide range of body weight (body mass index = 21-49 kg/m
2
) after an overnight fast and for 6 hr following ingestion of a standard test meal. The 6 hr integrated postprandial response of each hormone was estimated for each subject from the area of the response curve above basal concentration. Both fasting (r = 0.72, p < 0.0001) and postprandial (r = 0.45, p < 0.01) IRI were significantly correlated with degree of obesity, as expected. However, the fasting and postprandial plasma glucagon and glucagon-like immunoreactivity levels were not related to obesity of the subject and were not different for the obese (BMI > 35, n = 16) and nonobese (BMI < 30, n = 12) groups. Thus, there is no evidence for an abnormality in the response of these peptide hormones to a mixed meal in this obese population.</description><subject>Adult</subject><subject>Blood Glucose - analysis</subject><subject>Fasting</subject><subject>Food</subject><subject>Glucagon - blood</subject><subject>Glucagon-Like Peptides</subject><subject>Humans</subject><subject>Indians, North American</subject><subject>Insulin - blood</subject><subject>Middle Aged</subject><subject>Obesity - blood</subject><subject>Originals</subject><subject>Peptides - blood</subject><issn>0018-5043</issn><issn>1439-4286</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kD1PwzAQhi0EKqWwsiF5YnOxY-drRBUtlSraAWbLcS7FJYmLnSD13-PSwMZ0X-89unsRumV0ymgcP3gSUZoSRlmWpMkZGjPBcyKiLDlHYxq6JKaCX6Ir73ehFDkTIzRKuEizOB6jeq58Z9otVm2JN9Z3excyo2q8qZVvFF7UvVZb2_4IfguyMh-Al03Tt9aB0p35Mt0BKwf4xbombJsWrwvwgDcmQJZHZOuv0UWlag83Q5ygt_nT6-yZrNaL5exxRTSPso5AURaCReFEIXKahGbMmQCgUFUpA6YiKHMaq0yrlIKueMIZz3lWaJqyjDE-Qfcn7t7Zzx58JxvjNdS1asH2XmY0TvIoT4NwehJqZ713UMm9C_e6g2RUHu2VXh7tlYO9YeFuIPdFA-WffPAzzMlp3r0baEDubO_a8Op_vG-OrYNj</recordid><startdate>198305</startdate><enddate>198305</enddate><creator>Vasquez, Barbara</creator><creator>Nagulesparan, M.</creator><creator>Unger, R. H.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198305</creationdate><title>Fasting and Postprandial Plasma Glucagon and Glucagon-Like Immunoreactivity are Normal in Obese Pima Indians</title><author>Vasquez, Barbara ; Nagulesparan, M. ; Unger, R. H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c328t-ebdb41234744906c325314ee0eff71e1a2ed905a8ca70ecf36313938bc0718113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Adult</topic><topic>Blood Glucose - analysis</topic><topic>Fasting</topic><topic>Food</topic><topic>Glucagon - blood</topic><topic>Glucagon-Like Peptides</topic><topic>Humans</topic><topic>Indians, North American</topic><topic>Insulin - blood</topic><topic>Middle Aged</topic><topic>Obesity - blood</topic><topic>Originals</topic><topic>Peptides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vasquez, Barbara</creatorcontrib><creatorcontrib>Nagulesparan, M.</creatorcontrib><creatorcontrib>Unger, R. H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hormone and metabolic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vasquez, Barbara</au><au>Nagulesparan, M.</au><au>Unger, R. H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fasting and Postprandial Plasma Glucagon and Glucagon-Like Immunoreactivity are Normal in Obese Pima Indians</atitle><jtitle>Hormone and metabolic research</jtitle><addtitle>Horm Metab Res</addtitle><date>1983-05</date><risdate>1983</risdate><volume>15</volume><issue>5</issue><spage>218</spage><epage>220</epage><pages>218-220</pages><issn>0018-5043</issn><eissn>1439-4286</eissn><abstract>Summary
Glucose, insulin (IRI), glucagon (IRG) and GLI were measured in plasma samples obtained from 32 subjects representing a wide range of body weight (body mass index = 21-49 kg/m
2
) after an overnight fast and for 6 hr following ingestion of a standard test meal. The 6 hr integrated postprandial response of each hormone was estimated for each subject from the area of the response curve above basal concentration. Both fasting (r = 0.72, p < 0.0001) and postprandial (r = 0.45, p < 0.01) IRI were significantly correlated with degree of obesity, as expected. However, the fasting and postprandial plasma glucagon and glucagon-like immunoreactivity levels were not related to obesity of the subject and were not different for the obese (BMI > 35, n = 16) and nonobese (BMI < 30, n = 12) groups. Thus, there is no evidence for an abnormality in the response of these peptide hormones to a mixed meal in this obese population.</abstract><cop>Germany</cop><pmid>6347855</pmid><doi>10.1055/s-2007-1018676</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0018-5043 |
| ispartof | Hormone and metabolic research, 1983-05, Vol.15 (5), p.218-220 |
| issn | 0018-5043 1439-4286 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80569297 |
| source | MEDLINE; Thieme Connect Journals |
| subjects | Adult Blood Glucose - analysis Fasting Food Glucagon - blood Glucagon-Like Peptides Humans Indians, North American Insulin - blood Middle Aged Obesity - blood Originals Peptides - blood |
| title | Fasting and Postprandial Plasma Glucagon and Glucagon-Like Immunoreactivity are Normal in Obese Pima Indians |
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