The Efficacy in Navajo Infants of a Conjugate Vaccine Consisting of Haemophilus influenzae Type b Polysaccharide and Neisseria meningitidis Outer-Membrane Protein Complex
HAEMOPHILUS INFLUENZAE type b is the leading cause of meningitis and other serious infections in children. 1 2 3 The attack rates of this disease among certain Native American populations, such as Alaskan Eskimos, Navajos, and Apaches, are 5 to 10 times higher than those in the general U.S. populati...
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| Veröffentlicht in: | The New England journal of medicine 1991-06, Vol.324 (25), p.1767-1772 |
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| creator | Santosham, Mathuram Wolff, Mark Reid, Raymond Hohenboken, Matt Bateman, Massee Goepp, Julius Cortese, Margaret Sack, David Hill, Janné Newcomer, Wendy Capriotti, Linda Smith, Jeanne Owen, Marjorie Gahagan, Sheila Hu, Diana Kling, Renee Lukacs, Linda Ellis, Ronald W Vella, Philip P Calandra, Gary Matthews, Holly Ahonkhai, Vincent |
| description | HAEMOPHILUS INFLUENZAE type b is the leading cause of meningitis and other serious infections in children.
1
2
3
The attack rates of this disease among certain Native American populations, such as Alaskan Eskimos, Navajos, and Apaches, are 5 to 10 times higher than those in the general U.S. population.
4
5
6
Moreover, approximately 40 percent of the cases in these populations occur before the age of six months.
Recently, an
H. influenzae
conjugate vaccine was produced by covalently linking
H. influenzae
type b capsular polysaccharide to portions of the outer-membrane protein complex (OMPC) of
Neisseria meningitidis
serogroup B
7
(PedvaxHIB, Merck Sharp and Dohme Research . . . |
| doi_str_mv | 10.1056/NEJM199106203242503 |
| format | Article |
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1
2
3
The attack rates of this disease among certain Native American populations, such as Alaskan Eskimos, Navajos, and Apaches, are 5 to 10 times higher than those in the general U.S. population.
4
5
6
Moreover, approximately 40 percent of the cases in these populations occur before the age of six months.
Recently, an
H. influenzae
conjugate vaccine was produced by covalently linking
H. influenzae
type b capsular polysaccharide to portions of the outer-membrane protein complex (OMPC) of
Neisseria meningitidis
serogroup B
7
(PedvaxHIB, Merck Sharp and Dohme Research . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199106203242503</identifier><identifier>PMID: 1903846</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Age ; Aluminum ; Antibody Formation ; Antigens ; Bacterial Outer Membrane Proteins - adverse effects ; Bacterial Outer Membrane Proteins - immunology ; Bacterial Vaccines - adverse effects ; Bacterial Vaccines - immunology ; Bacteriology ; Biological and medical sciences ; Children ; Diphtheria ; Double-Blind Method ; Enzymes ; Follow-Up Studies ; Fundamental and applied biological sciences. Psychology ; Haemophilus Infections - prevention & control ; Haemophilus influenzae ; Haemophilus influenzae - immunology ; Haemophilus Vaccines ; Health services ; Humans ; Hygiene ; Immunization ; Immunization Schedule ; Indians, North American ; Infant ; Infants ; Laboratories ; Lactose ; Membrane proteins ; Meningitis ; Microbiology ; Native North Americans ; Neisseria meningitidis ; Neisseria meningitidis - immunology ; Osteomyelitis ; Pediatrics ; Polysaccharides, Bacterial - adverse effects ; Polysaccharides, Bacterial - immunology ; Proteins ; Public health ; Urine ; Vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies ; Vaccines, Synthetic - adverse effects ; Vaccines, Synthetic - immunology</subject><ispartof>The New England journal of medicine, 1991-06, Vol.324 (25), p.1767-1772</ispartof><rights>1991 INIST-CNRS</rights><rights>Copyright Massachusetts Medical Society Jun 20, 1991</rights><rights>Copyright Massachusetts Medical Society, Publishing Division Jun 20, 1991</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-acfefc63b9b92ea06143e25be1236a5e68ac6f2b9ab5458a7d41ec14b8b6c4273</citedby><cites>FETCH-LOGICAL-c491t-acfefc63b9b92ea06143e25be1236a5e68ac6f2b9ab5458a7d41ec14b8b6c4273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199106203242503$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJM199106203242503$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19794975$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1903846$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Santosham, Mathuram</creatorcontrib><creatorcontrib>Wolff, Mark</creatorcontrib><creatorcontrib>Reid, Raymond</creatorcontrib><creatorcontrib>Hohenboken, Matt</creatorcontrib><creatorcontrib>Bateman, Massee</creatorcontrib><creatorcontrib>Goepp, Julius</creatorcontrib><creatorcontrib>Cortese, Margaret</creatorcontrib><creatorcontrib>Sack, David</creatorcontrib><creatorcontrib>Hill, Janné</creatorcontrib><creatorcontrib>Newcomer, Wendy</creatorcontrib><creatorcontrib>Capriotti, Linda</creatorcontrib><creatorcontrib>Smith, Jeanne</creatorcontrib><creatorcontrib>Owen, Marjorie</creatorcontrib><creatorcontrib>Gahagan, Sheila</creatorcontrib><creatorcontrib>Hu, Diana</creatorcontrib><creatorcontrib>Kling, Renee</creatorcontrib><creatorcontrib>Lukacs, Linda</creatorcontrib><creatorcontrib>Ellis, Ronald W</creatorcontrib><creatorcontrib>Vella, Philip P</creatorcontrib><creatorcontrib>Calandra, Gary</creatorcontrib><creatorcontrib>Matthews, Holly</creatorcontrib><creatorcontrib>Ahonkhai, Vincent</creatorcontrib><title>The Efficacy in Navajo Infants of a Conjugate Vaccine Consisting of Haemophilus influenzae Type b Polysaccharide and Neisseria meningitidis Outer-Membrane Protein Complex</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>HAEMOPHILUS INFLUENZAE type b is the leading cause of meningitis and other serious infections in children.
1
2
3
The attack rates of this disease among certain Native American populations, such as Alaskan Eskimos, Navajos, and Apaches, are 5 to 10 times higher than those in the general U.S. population.
4
5
6
Moreover, approximately 40 percent of the cases in these populations occur before the age of six months.
Recently, an
H. influenzae
conjugate vaccine was produced by covalently linking
H. influenzae
type b capsular polysaccharide to portions of the outer-membrane protein complex (OMPC) of
Neisseria meningitidis
serogroup B
7
(PedvaxHIB, Merck Sharp and Dohme Research . . .</description><subject>Age</subject><subject>Aluminum</subject><subject>Antibody Formation</subject><subject>Antigens</subject><subject>Bacterial Outer Membrane Proteins - adverse effects</subject><subject>Bacterial Outer Membrane Proteins - immunology</subject><subject>Bacterial Vaccines - adverse effects</subject><subject>Bacterial Vaccines - immunology</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Children</subject><subject>Diphtheria</subject><subject>Double-Blind Method</subject><subject>Enzymes</subject><subject>Follow-Up Studies</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Haemophilus Infections - prevention & control</subject><subject>Haemophilus influenzae</subject><subject>Haemophilus influenzae - immunology</subject><subject>Haemophilus Vaccines</subject><subject>Health services</subject><subject>Humans</subject><subject>Hygiene</subject><subject>Immunization</subject><subject>Immunization Schedule</subject><subject>Indians, North American</subject><subject>Infant</subject><subject>Infants</subject><subject>Laboratories</subject><subject>Lactose</subject><subject>Membrane proteins</subject><subject>Meningitis</subject><subject>Microbiology</subject><subject>Native North Americans</subject><subject>Neisseria meningitidis</subject><subject>Neisseria meningitidis - immunology</subject><subject>Osteomyelitis</subject><subject>Pediatrics</subject><subject>Polysaccharides, Bacterial - adverse effects</subject><subject>Polysaccharides, Bacterial - immunology</subject><subject>Proteins</subject><subject>Public health</subject><subject>Urine</subject><subject>Vaccines</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</subject><subject>Vaccines, Synthetic - adverse effects</subject><subject>Vaccines, Synthetic - immunology</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkttuEzEQhlcIVNLCEyAkC1Ru0IJP66wvURRoUZv2InC7mnXGjaNdO7V3EeGReEocJRIIcfDNSJ7v_-egKYpnjL5htFJvF_OP10xrRhWngkteUfGgmLBKiFJKqh4WE0p5XcqpFo-L05Q2ND8m9UlxwjQVtVST4vtyjWRurTNgdsR5soAvsAnk0lvwQyLBEiCz4DfjHQxIPoMxzuP-J7k0OH-3Jy4A-7Bdu25M2cJ2I_pvgGS52yJpyW3odinr1hDdCgn4FVmgSwmjA9KjzyZucCuXyM04YCyvsW8j5CK3MQyYW5qFftvh1yfFIwtdwqfHeFZ8ej9fzi7Kq5sPl7N3V6WRmg0lGIvWKNHqVnMEqpgUyKsWGRcKKlQ1GGV5q6GtZFXDdCUZGibbulVG8qk4K14dfLcx3I-YhqZ3yWDX5Z7CmJo6715zWf0XZIoyprnO4IvfwE0Yo89DNJwLXUlW1xl6-TeI6VpIXislMiUOlIkhpYi22UbXQ9w1jDb7q2j-cBVZ9fzoPbY9rn5qDmeQ8-fHPCQDnc3rNy79gk211NP9xK8PXN-nxuOm_2fVH26qzOY</recordid><startdate>19910620</startdate><enddate>19910620</enddate><creator>Santosham, Mathuram</creator><creator>Wolff, Mark</creator><creator>Reid, Raymond</creator><creator>Hohenboken, Matt</creator><creator>Bateman, Massee</creator><creator>Goepp, Julius</creator><creator>Cortese, Margaret</creator><creator>Sack, David</creator><creator>Hill, Janné</creator><creator>Newcomer, Wendy</creator><creator>Capriotti, Linda</creator><creator>Smith, Jeanne</creator><creator>Owen, Marjorie</creator><creator>Gahagan, Sheila</creator><creator>Hu, Diana</creator><creator>Kling, Renee</creator><creator>Lukacs, Linda</creator><creator>Ellis, Ronald W</creator><creator>Vella, Philip P</creator><creator>Calandra, Gary</creator><creator>Matthews, Holly</creator><creator>Ahonkhai, Vincent</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19910620</creationdate><title>The Efficacy in Navajo Infants of a Conjugate Vaccine Consisting of Haemophilus influenzae Type b Polysaccharide and Neisseria meningitidis Outer-Membrane Protein Complex</title><author>Santosham, Mathuram ; Wolff, Mark ; Reid, Raymond ; Hohenboken, Matt ; Bateman, Massee ; Goepp, Julius ; Cortese, Margaret ; Sack, David ; Hill, Janné ; Newcomer, Wendy ; Capriotti, Linda ; Smith, Jeanne ; Owen, Marjorie ; Gahagan, Sheila ; Hu, Diana ; Kling, Renee ; Lukacs, Linda ; Ellis, Ronald W ; Vella, Philip P ; Calandra, Gary ; Matthews, Holly ; Ahonkhai, Vincent</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-acfefc63b9b92ea06143e25be1236a5e68ac6f2b9ab5458a7d41ec14b8b6c4273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Age</topic><topic>Aluminum</topic><topic>Antibody Formation</topic><topic>Antigens</topic><topic>Bacterial Outer Membrane Proteins - adverse effects</topic><topic>Bacterial Outer Membrane Proteins - immunology</topic><topic>Bacterial Vaccines - adverse effects</topic><topic>Bacterial Vaccines - immunology</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Children</topic><topic>Diphtheria</topic><topic>Double-Blind Method</topic><topic>Enzymes</topic><topic>Follow-Up Studies</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Haemophilus Infections - prevention & control</topic><topic>Haemophilus influenzae</topic><topic>Haemophilus influenzae - immunology</topic><topic>Haemophilus Vaccines</topic><topic>Health services</topic><topic>Humans</topic><topic>Hygiene</topic><topic>Immunization</topic><topic>Immunization Schedule</topic><topic>Indians, North American</topic><topic>Infant</topic><topic>Infants</topic><topic>Laboratories</topic><topic>Lactose</topic><topic>Membrane proteins</topic><topic>Meningitis</topic><topic>Microbiology</topic><topic>Native North Americans</topic><topic>Neisseria meningitidis</topic><topic>Neisseria meningitidis - immunology</topic><topic>Osteomyelitis</topic><topic>Pediatrics</topic><topic>Polysaccharides, Bacterial - adverse effects</topic><topic>Polysaccharides, Bacterial - immunology</topic><topic>Proteins</topic><topic>Public health</topic><topic>Urine</topic><topic>Vaccines</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</topic><topic>Vaccines, Synthetic - adverse effects</topic><topic>Vaccines, Synthetic - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Santosham, Mathuram</creatorcontrib><creatorcontrib>Wolff, Mark</creatorcontrib><creatorcontrib>Reid, Raymond</creatorcontrib><creatorcontrib>Hohenboken, Matt</creatorcontrib><creatorcontrib>Bateman, Massee</creatorcontrib><creatorcontrib>Goepp, Julius</creatorcontrib><creatorcontrib>Cortese, Margaret</creatorcontrib><creatorcontrib>Sack, David</creatorcontrib><creatorcontrib>Hill, Janné</creatorcontrib><creatorcontrib>Newcomer, Wendy</creatorcontrib><creatorcontrib>Capriotti, Linda</creatorcontrib><creatorcontrib>Smith, Jeanne</creatorcontrib><creatorcontrib>Owen, Marjorie</creatorcontrib><creatorcontrib>Gahagan, Sheila</creatorcontrib><creatorcontrib>Hu, Diana</creatorcontrib><creatorcontrib>Kling, Renee</creatorcontrib><creatorcontrib>Lukacs, Linda</creatorcontrib><creatorcontrib>Ellis, Ronald W</creatorcontrib><creatorcontrib>Vella, Philip P</creatorcontrib><creatorcontrib>Calandra, Gary</creatorcontrib><creatorcontrib>Matthews, Holly</creatorcontrib><creatorcontrib>Ahonkhai, Vincent</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Santosham, Mathuram</au><au>Wolff, Mark</au><au>Reid, Raymond</au><au>Hohenboken, Matt</au><au>Bateman, Massee</au><au>Goepp, Julius</au><au>Cortese, Margaret</au><au>Sack, David</au><au>Hill, Janné</au><au>Newcomer, Wendy</au><au>Capriotti, Linda</au><au>Smith, Jeanne</au><au>Owen, Marjorie</au><au>Gahagan, Sheila</au><au>Hu, Diana</au><au>Kling, Renee</au><au>Lukacs, Linda</au><au>Ellis, Ronald W</au><au>Vella, Philip P</au><au>Calandra, Gary</au><au>Matthews, Holly</au><au>Ahonkhai, Vincent</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Efficacy in Navajo Infants of a Conjugate Vaccine Consisting of Haemophilus influenzae Type b Polysaccharide and Neisseria meningitidis Outer-Membrane Protein Complex</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1991-06-20</date><risdate>1991</risdate><volume>324</volume><issue>25</issue><spage>1767</spage><epage>1772</epage><pages>1767-1772</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>HAEMOPHILUS INFLUENZAE type b is the leading cause of meningitis and other serious infections in children.
1
2
3
The attack rates of this disease among certain Native American populations, such as Alaskan Eskimos, Navajos, and Apaches, are 5 to 10 times higher than those in the general U.S. population.
4
5
6
Moreover, approximately 40 percent of the cases in these populations occur before the age of six months.
Recently, an
H. influenzae
conjugate vaccine was produced by covalently linking
H. influenzae
type b capsular polysaccharide to portions of the outer-membrane protein complex (OMPC) of
Neisseria meningitidis
serogroup B
7
(PedvaxHIB, Merck Sharp and Dohme Research . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>1903846</pmid><doi>10.1056/NEJM199106203242503</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 1991-06, Vol.324 (25), p.1767-1772 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80569245 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; New England Journal of Medicine |
| subjects | Age Aluminum Antibody Formation Antigens Bacterial Outer Membrane Proteins - adverse effects Bacterial Outer Membrane Proteins - immunology Bacterial Vaccines - adverse effects Bacterial Vaccines - immunology Bacteriology Biological and medical sciences Children Diphtheria Double-Blind Method Enzymes Follow-Up Studies Fundamental and applied biological sciences. Psychology Haemophilus Infections - prevention & control Haemophilus influenzae Haemophilus influenzae - immunology Haemophilus Vaccines Health services Humans Hygiene Immunization Immunization Schedule Indians, North American Infant Infants Laboratories Lactose Membrane proteins Meningitis Microbiology Native North Americans Neisseria meningitidis Neisseria meningitidis - immunology Osteomyelitis Pediatrics Polysaccharides, Bacterial - adverse effects Polysaccharides, Bacterial - immunology Proteins Public health Urine Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, Synthetic - adverse effects Vaccines, Synthetic - immunology |
| title | The Efficacy in Navajo Infants of a Conjugate Vaccine Consisting of Haemophilus influenzae Type b Polysaccharide and Neisseria meningitidis Outer-Membrane Protein Complex |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T00%3A50%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Efficacy%20in%20Navajo%20Infants%20of%20a%20Conjugate%20Vaccine%20Consisting%20of%20Haemophilus%20influenzae%20Type%20b%20Polysaccharide%20and%20Neisseria%20meningitidis%20Outer-Membrane%20Protein%20Complex&rft.jtitle=The%20New%20England%20journal%20of%20medicine&rft.au=Santosham,%20Mathuram&rft.date=1991-06-20&rft.volume=324&rft.issue=25&rft.spage=1767&rft.epage=1772&rft.pages=1767-1772&rft.issn=0028-4793&rft.eissn=1533-4406&rft.coden=NEJMAG&rft_id=info:doi/10.1056/NEJM199106203242503&rft_dat=%3Cproquest_cross%3E1983428663%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1983428663&rft_id=info:pmid/1903846&rfr_iscdi=true |