The role of adrenal medullary catecholamine release in the response to a cold pressor test
We studied the effects of a cold pressor test on the plasma catecholamine levels of ten patients undergoing coronary angiography, to determine whether the pressor changes were related to adrenergic activity. To investigate the relative contribution of adrenal medullary catecholamine release, we subj...
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| Veröffentlicht in: | Cardiovascular research 1983-04, Vol.17 (4), p.189-191 |
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| container_end_page | 191 |
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| container_issue | 4 |
| container_start_page | 189 |
| container_title | Cardiovascular research |
| container_volume | 17 |
| creator | CUMMINGS, MARY F STEELE, PETER M MAHAR, LEO J M FREWIN, DEREK B RUSSELL, W JOHN |
| description | We studied the effects of a cold pressor test on the plasma catecholamine levels of ten patients undergoing coronary angiography, to determine whether the pressor changes were related to adrenergic activity. To investigate the relative contribution of adrenal medullary catecholamine release, we subjected two adrenalectomised volunteers to the same test. Arterial blood was assayed for dopamine (DA), adrenaline (A) and noradrenaline (NA). We found significant rises in the levels of all three catecholamines in the angiography patients, accompanied by a significant elevation in arterial blood pressure. In both the adrenalectomised patients a rise in blood pressure was seen but no significant rise in plasma catecholamines could be demonstrated. We postulate that although adrenal medullary catecholamine release occurs in response to the cold pressor test, the blood pressure elevation is independent of such adrenal activity. Sampling radial arterial blood may not reflect changes in plasma levels of peripherally released NA. |
| doi_str_mv | 10.1093/cvr/17.4.189 |
| format | Article |
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To investigate the relative contribution of adrenal medullary catecholamine release, we subjected two adrenalectomised volunteers to the same test. Arterial blood was assayed for dopamine (DA), adrenaline (A) and noradrenaline (NA). We found significant rises in the levels of all three catecholamines in the angiography patients, accompanied by a significant elevation in arterial blood pressure. In both the adrenalectomised patients a rise in blood pressure was seen but no significant rise in plasma catecholamines could be demonstrated. We postulate that although adrenal medullary catecholamine release occurs in response to the cold pressor test, the blood pressure elevation is independent of such adrenal activity. Sampling radial arterial blood may not reflect changes in plasma levels of peripherally released NA.</description><identifier>ISSN: 0008-6363</identifier><identifier>EISSN: 1755-3245</identifier><identifier>DOI: 10.1093/cvr/17.4.189</identifier><identifier>PMID: 6871908</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>adrenal medulla ; Adrenal Medulla - metabolism ; Adrenalectomy ; Adult ; Aged ; Blood Pressure ; catecholamines ; Catecholamines - blood ; Catecholamines - metabolism ; cold pressor test ; Cold Temperature ; Dopamine - blood ; Dopamine - metabolism ; Epinephrine - blood ; Epinephrine - metabolism ; Female ; Humans ; Male ; Middle Aged ; Norepinephrine - blood ; Norepinephrine - metabolism</subject><ispartof>Cardiovascular research, 1983-04, Vol.17 (4), p.189-191</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c460t-850fdee798eae8672c188deb0f563cd7bb4c80decbe6d94fb68c73d90e1cfb873</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6871908$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CUMMINGS, MARY F</creatorcontrib><creatorcontrib>STEELE, PETER M</creatorcontrib><creatorcontrib>MAHAR, LEO J M</creatorcontrib><creatorcontrib>FREWIN, DEREK B</creatorcontrib><creatorcontrib>RUSSELL, W JOHN</creatorcontrib><title>The role of adrenal medullary catecholamine release in the response to a cold pressor test</title><title>Cardiovascular research</title><addtitle>Cardiovasc Res</addtitle><description>We studied the effects of a cold pressor test on the plasma catecholamine levels of ten patients undergoing coronary angiography, to determine whether the pressor changes were related to adrenergic activity. To investigate the relative contribution of adrenal medullary catecholamine release, we subjected two adrenalectomised volunteers to the same test. Arterial blood was assayed for dopamine (DA), adrenaline (A) and noradrenaline (NA). We found significant rises in the levels of all three catecholamines in the angiography patients, accompanied by a significant elevation in arterial blood pressure. In both the adrenalectomised patients a rise in blood pressure was seen but no significant rise in plasma catecholamines could be demonstrated. We postulate that although adrenal medullary catecholamine release occurs in response to the cold pressor test, the blood pressure elevation is independent of such adrenal activity. Sampling radial arterial blood may not reflect changes in plasma levels of peripherally released NA.</description><subject>adrenal medulla</subject><subject>Adrenal Medulla - metabolism</subject><subject>Adrenalectomy</subject><subject>Adult</subject><subject>Aged</subject><subject>Blood Pressure</subject><subject>catecholamines</subject><subject>Catecholamines - blood</subject><subject>Catecholamines - metabolism</subject><subject>cold pressor test</subject><subject>Cold Temperature</subject><subject>Dopamine - blood</subject><subject>Dopamine - metabolism</subject><subject>Epinephrine - blood</subject><subject>Epinephrine - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Norepinephrine - blood</subject><subject>Norepinephrine - metabolism</subject><issn>0008-6363</issn><issn>1755-3245</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1PAjEQhhujQURvXk168uRCS7cfezRExATiQTSGS9NtZ8PqssV2MfrvLYF4aqbvMzOZB6FrSoaUFGxkv8OIymE-pKo4QX0qOc_YOOenqE8IUZlggp2jixg_Usm5zHuoJ5SkBVF9tFquAQffAPYVNi5Aaxq8AbdrGhN-sTUd2LVvzKZuEwcNmAi4bnG3b4O49W2qO48Ntr5xeJv-og-4g9hdorPKNBGuju8AvU4flpNZNn9-fJrczzObC9JlipPKAchCgQEl5NhSpRyUpOKCWSfLMreKOLAlCFfkVSmUlcwVBKitSiXZAN0e5m6D_9qlxXpTRwvpgBb8LmpFuBBpSwLvDqANPsYAld6GepPO1JTovUqdVGoqda6TyoTfHOfuymTkHz66S3l2yOvYwc9_bMKnFpJJrmfvK_2yeMuLxXShx-wPSheAiA</recordid><startdate>198304</startdate><enddate>198304</enddate><creator>CUMMINGS, MARY F</creator><creator>STEELE, PETER M</creator><creator>MAHAR, LEO J M</creator><creator>FREWIN, DEREK B</creator><creator>RUSSELL, W JOHN</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198304</creationdate><title>The role of adrenal medullary catecholamine release in the response to a cold pressor test</title><author>CUMMINGS, MARY F ; STEELE, PETER M ; MAHAR, LEO J M ; FREWIN, DEREK B ; RUSSELL, W JOHN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c460t-850fdee798eae8672c188deb0f563cd7bb4c80decbe6d94fb68c73d90e1cfb873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>adrenal medulla</topic><topic>Adrenal Medulla - metabolism</topic><topic>Adrenalectomy</topic><topic>Adult</topic><topic>Aged</topic><topic>Blood Pressure</topic><topic>catecholamines</topic><topic>Catecholamines - blood</topic><topic>Catecholamines - metabolism</topic><topic>cold pressor test</topic><topic>Cold Temperature</topic><topic>Dopamine - blood</topic><topic>Dopamine - metabolism</topic><topic>Epinephrine - blood</topic><topic>Epinephrine - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Norepinephrine - blood</topic><topic>Norepinephrine - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CUMMINGS, MARY F</creatorcontrib><creatorcontrib>STEELE, PETER M</creatorcontrib><creatorcontrib>MAHAR, LEO J M</creatorcontrib><creatorcontrib>FREWIN, DEREK B</creatorcontrib><creatorcontrib>RUSSELL, W JOHN</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cardiovascular research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CUMMINGS, MARY F</au><au>STEELE, PETER M</au><au>MAHAR, LEO J M</au><au>FREWIN, DEREK B</au><au>RUSSELL, W JOHN</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of adrenal medullary catecholamine release in the response to a cold pressor test</atitle><jtitle>Cardiovascular research</jtitle><addtitle>Cardiovasc Res</addtitle><date>1983-04</date><risdate>1983</risdate><volume>17</volume><issue>4</issue><spage>189</spage><epage>191</epage><pages>189-191</pages><issn>0008-6363</issn><eissn>1755-3245</eissn><abstract>We studied the effects of a cold pressor test on the plasma catecholamine levels of ten patients undergoing coronary angiography, to determine whether the pressor changes were related to adrenergic activity. To investigate the relative contribution of adrenal medullary catecholamine release, we subjected two adrenalectomised volunteers to the same test. Arterial blood was assayed for dopamine (DA), adrenaline (A) and noradrenaline (NA). We found significant rises in the levels of all three catecholamines in the angiography patients, accompanied by a significant elevation in arterial blood pressure. In both the adrenalectomised patients a rise in blood pressure was seen but no significant rise in plasma catecholamines could be demonstrated. We postulate that although adrenal medullary catecholamine release occurs in response to the cold pressor test, the blood pressure elevation is independent of such adrenal activity. Sampling radial arterial blood may not reflect changes in plasma levels of peripherally released NA.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>6871908</pmid><doi>10.1093/cvr/17.4.189</doi><tpages>3</tpages></addata></record> |
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| ispartof | Cardiovascular research, 1983-04, Vol.17 (4), p.189-191 |
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| language | eng |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | adrenal medulla Adrenal Medulla - metabolism Adrenalectomy Adult Aged Blood Pressure catecholamines Catecholamines - blood Catecholamines - metabolism cold pressor test Cold Temperature Dopamine - blood Dopamine - metabolism Epinephrine - blood Epinephrine - metabolism Female Humans Male Middle Aged Norepinephrine - blood Norepinephrine - metabolism |
| title | The role of adrenal medullary catecholamine release in the response to a cold pressor test |
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