Effect of propionyl-L-carnitine on mechanical function of isolated rabbit heart
We studied the acute and chronic effects of propionyl-L-carnitine (PLC) on mechanical function of isolated rabbit heart. Propionyl-L-carnitine was either directly delivered in the perfusate (10(-9) to 10(-3) M) or intraperitoneally injected (250 mg/kg) for 10 days to the animals. When added acutely,...
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| Veröffentlicht in: | Cardiovascular drugs and therapy 1991-02, Vol.5 Suppl 1 (1), p.17-23 |
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| container_title | Cardiovascular drugs and therapy |
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| creator | Ferrari, R Pasini, E Condorelli, E Boraso, A Lisciani, R Marzo, A Visiou, O |
| description | We studied the acute and chronic effects of propionyl-L-carnitine (PLC) on mechanical function of isolated rabbit heart. Propionyl-L-carnitine was either directly delivered in the perfusate (10(-9) to 10(-3) M) or intraperitoneally injected (250 mg/kg) for 10 days to the animals. When added acutely, propionyl-L-carnitine had no effect on inotropism, heart rate, or coronary perfusion pressure. When added chronically, propionyl-L-carnitine induced a positive inotropic effect, with no changes in heart rate or in coronary perfusion pressure, and it ameliorated the pressure-volume relationship. This effect of propionyl-L-carnitine was independent of the calcium concentration of the perfusion medium, but it was correlated with an increase in the myocardial content of propionyl-L-carnitine. The effect was not apparent after 5 days of treatment, although the tissue content of propionyl-L-carnitine remained unchanged. These data suggest that propionyl-L-carnitine, when given chronically, exerts a positive inotropic effect. |
| doi_str_mv | 10.1007/BF00128239 |
| format | Article |
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These data suggest that propionyl-L-carnitine, when given chronically, exerts a positive inotropic effect.</description><identifier>ISSN: 0920-3206</identifier><identifier>EISSN: 1573-7241</identifier><identifier>DOI: 10.1007/BF00128239</identifier><identifier>PMID: 2031870</identifier><language>eng</language><publisher>United States</publisher><subject>Acetylcarnitine - blood ; Acetylcarnitine - metabolism ; Animals ; Carnitine - administration & dosage ; Carnitine - analogs & derivatives ; Carnitine - blood ; Carnitine - metabolism ; Carnitine - pharmacology ; Electric Stimulation ; Heart - drug effects ; Injections, Intraperitoneal ; Male ; Myocardial Contraction - drug effects ; Rabbits</subject><ispartof>Cardiovascular drugs and therapy, 1991-02, Vol.5 Suppl 1 (1), p.17-23</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c282t-23d30d38ec64ed0ecbe6bf6e396448121a0def10a919985adba30608237055b83</citedby><cites>FETCH-LOGICAL-c282t-23d30d38ec64ed0ecbe6bf6e396448121a0def10a919985adba30608237055b83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2031870$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ferrari, R</creatorcontrib><creatorcontrib>Pasini, E</creatorcontrib><creatorcontrib>Condorelli, E</creatorcontrib><creatorcontrib>Boraso, A</creatorcontrib><creatorcontrib>Lisciani, R</creatorcontrib><creatorcontrib>Marzo, A</creatorcontrib><creatorcontrib>Visiou, O</creatorcontrib><title>Effect of propionyl-L-carnitine on mechanical function of isolated rabbit heart</title><title>Cardiovascular drugs and therapy</title><addtitle>Cardiovasc Drugs Ther</addtitle><description>We studied the acute and chronic effects of propionyl-L-carnitine (PLC) on mechanical function of isolated rabbit heart. Propionyl-L-carnitine was either directly delivered in the perfusate (10(-9) to 10(-3) M) or intraperitoneally injected (250 mg/kg) for 10 days to the animals. When added acutely, propionyl-L-carnitine had no effect on inotropism, heart rate, or coronary perfusion pressure. When added chronically, propionyl-L-carnitine induced a positive inotropic effect, with no changes in heart rate or in coronary perfusion pressure, and it ameliorated the pressure-volume relationship. This effect of propionyl-L-carnitine was independent of the calcium concentration of the perfusion medium, but it was correlated with an increase in the myocardial content of propionyl-L-carnitine. The effect was not apparent after 5 days of treatment, although the tissue content of propionyl-L-carnitine remained unchanged. These data suggest that propionyl-L-carnitine, when given chronically, exerts a positive inotropic effect.</description><subject>Acetylcarnitine - blood</subject><subject>Acetylcarnitine - metabolism</subject><subject>Animals</subject><subject>Carnitine - administration & dosage</subject><subject>Carnitine - analogs & derivatives</subject><subject>Carnitine - blood</subject><subject>Carnitine - metabolism</subject><subject>Carnitine - pharmacology</subject><subject>Electric Stimulation</subject><subject>Heart - drug effects</subject><subject>Injections, Intraperitoneal</subject><subject>Male</subject><subject>Myocardial Contraction - drug effects</subject><subject>Rabbits</subject><issn>0920-3206</issn><issn>1573-7241</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0DFPwzAQBWALgUopLOxImRiQAmc7cZIRqhaQKnWBObKds2qUOMV2Bv49rlrBdMunp3ePkFsKjxSgenpZA1BWM96ckTktK55XrKDnZA4Ng5wzEJfkKoQvSLhp6hmZMeC0rmBOtitjUMdsNNnej3s7up8-3-RaemejdZiNLhtQ76SzWvaZmZyOCR28DWMvI3aZl0rZmO1Q-nhNLozsA96c7oJ8rlcfy7d8s319Xz6n5NQz5ox3HDpeoxYFdoBaoVBGIG9EUdSUUQkdGgqyoalwKTslOQhIL1ZQlqrmC3J_zE2tvycMsR1s0Nj30uE4hbaGUgjBmgQfjlD7MQSPpt17O0j_01JoD-u1_-slfHdKndSA3R89zcV_AdgZaRw</recordid><startdate>199102</startdate><enddate>199102</enddate><creator>Ferrari, R</creator><creator>Pasini, E</creator><creator>Condorelli, E</creator><creator>Boraso, A</creator><creator>Lisciani, R</creator><creator>Marzo, A</creator><creator>Visiou, O</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199102</creationdate><title>Effect of propionyl-L-carnitine on mechanical function of isolated rabbit heart</title><author>Ferrari, R ; Pasini, E ; Condorelli, E ; Boraso, A ; Lisciani, R ; Marzo, A ; Visiou, O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c282t-23d30d38ec64ed0ecbe6bf6e396448121a0def10a919985adba30608237055b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Acetylcarnitine - blood</topic><topic>Acetylcarnitine - metabolism</topic><topic>Animals</topic><topic>Carnitine - administration & dosage</topic><topic>Carnitine - analogs & derivatives</topic><topic>Carnitine - blood</topic><topic>Carnitine - metabolism</topic><topic>Carnitine - pharmacology</topic><topic>Electric Stimulation</topic><topic>Heart - drug effects</topic><topic>Injections, Intraperitoneal</topic><topic>Male</topic><topic>Myocardial Contraction - drug effects</topic><topic>Rabbits</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ferrari, R</creatorcontrib><creatorcontrib>Pasini, E</creatorcontrib><creatorcontrib>Condorelli, E</creatorcontrib><creatorcontrib>Boraso, A</creatorcontrib><creatorcontrib>Lisciani, R</creatorcontrib><creatorcontrib>Marzo, A</creatorcontrib><creatorcontrib>Visiou, O</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cardiovascular drugs and therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ferrari, R</au><au>Pasini, E</au><au>Condorelli, E</au><au>Boraso, A</au><au>Lisciani, R</au><au>Marzo, A</au><au>Visiou, O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of propionyl-L-carnitine on mechanical function of isolated rabbit heart</atitle><jtitle>Cardiovascular drugs and therapy</jtitle><addtitle>Cardiovasc Drugs Ther</addtitle><date>1991-02</date><risdate>1991</risdate><volume>5 Suppl 1</volume><issue>1</issue><spage>17</spage><epage>23</epage><pages>17-23</pages><issn>0920-3206</issn><eissn>1573-7241</eissn><abstract>We studied the acute and chronic effects of propionyl-L-carnitine (PLC) on mechanical function of isolated rabbit heart. Propionyl-L-carnitine was either directly delivered in the perfusate (10(-9) to 10(-3) M) or intraperitoneally injected (250 mg/kg) for 10 days to the animals. When added acutely, propionyl-L-carnitine had no effect on inotropism, heart rate, or coronary perfusion pressure. When added chronically, propionyl-L-carnitine induced a positive inotropic effect, with no changes in heart rate or in coronary perfusion pressure, and it ameliorated the pressure-volume relationship. This effect of propionyl-L-carnitine was independent of the calcium concentration of the perfusion medium, but it was correlated with an increase in the myocardial content of propionyl-L-carnitine. The effect was not apparent after 5 days of treatment, although the tissue content of propionyl-L-carnitine remained unchanged. These data suggest that propionyl-L-carnitine, when given chronically, exerts a positive inotropic effect.</abstract><cop>United States</cop><pmid>2031870</pmid><doi>10.1007/BF00128239</doi><tpages>7</tpages></addata></record> |
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| ispartof | Cardiovascular drugs and therapy, 1991-02, Vol.5 Suppl 1 (1), p.17-23 |
| issn | 0920-3206 1573-7241 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Acetylcarnitine - blood Acetylcarnitine - metabolism Animals Carnitine - administration & dosage Carnitine - analogs & derivatives Carnitine - blood Carnitine - metabolism Carnitine - pharmacology Electric Stimulation Heart - drug effects Injections, Intraperitoneal Male Myocardial Contraction - drug effects Rabbits |
| title | Effect of propionyl-L-carnitine on mechanical function of isolated rabbit heart |
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