Correlations on radioimmunoassay, fluorescence polarization immunoassay, and enzyme immunoassay of cannabis metabolites with gas chromatography/mass spectrometry analysis of 11-nor-Δ 9-tetrahydrocannabinol-9-carboxylic acid in urine specimens
Results obtained from three commercial immunoassay kits, Abuscreen ®, TDx ®, and EMIT ®, commonly used for the initial test of urine cannabinoids (and metabolites) were correlated with the 11-nor-Δ 9-tetrahydrocannabinol-9-carboxylic acid (9-THC-COOH) concentration as determined by GC/MS. Correlatio...
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| Veröffentlicht in: | Forensic science international 1991, Vol.49 (1), p.43-56 |
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| container_title | Forensic science international |
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| creator | Weaver, Michael L. Gan, Ber K. Allen, Ellen Diane Baugh, L. Liao, Fang-Ying Liu, Ray H. Langner, Jeffery G. Walia, Amrik S. Foster Cook, L. |
| description | Results obtained from three commercial immunoassay kits, Abuscreen
®, TDx
®, and EMIT
®, commonly used for the initial test of urine cannabinoids (and metabolites) were correlated with the 11-nor-Δ
9-tetrahydrocannabinol-9-carboxylic acid (9-THC-COOH) concentration as determined by GC/MS. Correlation coefficients obtained based on 26 (out of 1359 total sample population) highly relevant samples, are 0.601 and 0.438 for Abuscreen
® and TDx
®. Correlation coefficients obtained from a parallel study on a different set of 47 (out of 5070 total sample population) highly relevant specimens are 0.658 and 0.575 for Abuscreen
® and Emit
®. The immunoassay concentration levels, that correspond to the commonly used 15 ng/ml GC/MS cutoff value for 9-THC-COOH, as calculated from the regression equations are 82 ng/ml and 75 ng/ml for TDx
® and EMIT
® and 120 ng/ml and 72 ng/ml for Abuscreen
® manufactured at two different time periods. The difference of these calculated corresponding concentrations provides quantitative evidence of the reagent specificity differences. |
| doi_str_mv | 10.1016/0379-0738(91)90170-N |
| format | Article |
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®, TDx
®, and EMIT
®, commonly used for the initial test of urine cannabinoids (and metabolites) were correlated with the 11-nor-Δ
9-tetrahydrocannabinol-9-carboxylic acid (9-THC-COOH) concentration as determined by GC/MS. Correlation coefficients obtained based on 26 (out of 1359 total sample population) highly relevant samples, are 0.601 and 0.438 for Abuscreen
® and TDx
®. Correlation coefficients obtained from a parallel study on a different set of 47 (out of 5070 total sample population) highly relevant specimens are 0.658 and 0.575 for Abuscreen
® and Emit
®. The immunoassay concentration levels, that correspond to the commonly used 15 ng/ml GC/MS cutoff value for 9-THC-COOH, as calculated from the regression equations are 82 ng/ml and 75 ng/ml for TDx
® and EMIT
® and 120 ng/ml and 72 ng/ml for Abuscreen
® manufactured at two different time periods. The difference of these calculated corresponding concentrations provides quantitative evidence of the reagent specificity differences.</description><identifier>ISSN: 0379-0738</identifier><identifier>EISSN: 1872-6283</identifier><identifier>DOI: 10.1016/0379-0738(91)90170-N</identifier><identifier>PMID: 1851715</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Abuscreen ; Cannabinoid ; Cannabinoids - urine ; Dronabinol - analogs & derivatives ; Dronabinol - urine ; Emit ; Fluorescence Polarization Immunoassay ; Gas Chromatography-Mass Spectrometry ; GC/MS ; Humans ; Immunoassay ; Immunoenzyme Techniques ; Marijuana ; Predictive Value of Tests ; Radioimmunoassay ; Reproducibility of Results ; TDx ; THC</subject><ispartof>Forensic science international, 1991, Vol.49 (1), p.43-56</ispartof><rights>1991</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/037907389190170N$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,4009,27902,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1851715$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weaver, Michael L.</creatorcontrib><creatorcontrib>Gan, Ber K.</creatorcontrib><creatorcontrib>Allen, Ellen</creatorcontrib><creatorcontrib>Diane Baugh, L.</creatorcontrib><creatorcontrib>Liao, Fang-Ying</creatorcontrib><creatorcontrib>Liu, Ray H.</creatorcontrib><creatorcontrib>Langner, Jeffery G.</creatorcontrib><creatorcontrib>Walia, Amrik S.</creatorcontrib><creatorcontrib>Foster Cook, L.</creatorcontrib><title>Correlations on radioimmunoassay, fluorescence polarization immunoassay, and enzyme immunoassay of cannabis metabolites with gas chromatography/mass spectrometry analysis of 11-nor-Δ 9-tetrahydrocannabinol-9-carboxylic acid in urine specimens</title><title>Forensic science international</title><addtitle>Forensic Sci Int</addtitle><description>Results obtained from three commercial immunoassay kits, Abuscreen
®, TDx
®, and EMIT
®, commonly used for the initial test of urine cannabinoids (and metabolites) were correlated with the 11-nor-Δ
9-tetrahydrocannabinol-9-carboxylic acid (9-THC-COOH) concentration as determined by GC/MS. Correlation coefficients obtained based on 26 (out of 1359 total sample population) highly relevant samples, are 0.601 and 0.438 for Abuscreen
® and TDx
®. Correlation coefficients obtained from a parallel study on a different set of 47 (out of 5070 total sample population) highly relevant specimens are 0.658 and 0.575 for Abuscreen
® and Emit
®. The immunoassay concentration levels, that correspond to the commonly used 15 ng/ml GC/MS cutoff value for 9-THC-COOH, as calculated from the regression equations are 82 ng/ml and 75 ng/ml for TDx
® and EMIT
® and 120 ng/ml and 72 ng/ml for Abuscreen
® manufactured at two different time periods. The difference of these calculated corresponding concentrations provides quantitative evidence of the reagent specificity differences.</description><subject>Abuscreen</subject><subject>Cannabinoid</subject><subject>Cannabinoids - urine</subject><subject>Dronabinol - analogs & derivatives</subject><subject>Dronabinol - urine</subject><subject>Emit</subject><subject>Fluorescence Polarization Immunoassay</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>GC/MS</subject><subject>Humans</subject><subject>Immunoassay</subject><subject>Immunoenzyme Techniques</subject><subject>Marijuana</subject><subject>Predictive Value of Tests</subject><subject>Radioimmunoassay</subject><subject>Reproducibility of Results</subject><subject>TDx</subject><subject>THC</subject><issn>0379-0738</issn><issn>1872-6283</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVktuKFDEQhoMo67j6Bgq5EgXjJt2dPtwIMniCZb3R61Cd1OxEcmiTbrX3OXwuX8YXMDM7iF4F6v_qT1F_EfJY8JeCi_aC193AeFf3zwbxfOCi4-zqDtmIvqtYW_X1XbL5i9wnD3L-wjmXsmrPyJnopeiE3JDf25gSOphtDJnGQBMYG633S4iQM6wv6M4tMWHWGDTSKTpI9ubI0_8wCIZiuFk9_luncUc1hACjzdTjDGN0dsZMv9t5T68hU71P0cMcrxNM-_XClzaaJ9RzKeOc1mIMbs2lvVgJwUJM7NdPOrC5qLBfTYqnD0J0bGAa0hh_rM5qCtoaagNdkg14NLUeQ35I7u3AZXx0es_J57dvPm3fs8uP7z5sX18yFLyXDLu6aXRrpJGjqHmzk13FuWk1tuPIGxRtK5u-6npsu6EaAYSoJNbDCLKvYBD1OXl66zul-HXBPCtvyxqdg4Bxyarnsq0bWRXwyQlcRo9GTcl6SKs6pVT0V7c6lmm_WUwqa3uIw9hUFqVMtEpwdbgKdYhcHSJXg1DHq1BX9R-SebFU</recordid><startdate>1991</startdate><enddate>1991</enddate><creator>Weaver, Michael L.</creator><creator>Gan, Ber K.</creator><creator>Allen, Ellen</creator><creator>Diane Baugh, L.</creator><creator>Liao, Fang-Ying</creator><creator>Liu, Ray H.</creator><creator>Langner, Jeffery G.</creator><creator>Walia, Amrik S.</creator><creator>Foster Cook, L.</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>1991</creationdate><title>Correlations on radioimmunoassay, fluorescence polarization immunoassay, and enzyme immunoassay of cannabis metabolites with gas chromatography/mass spectrometry analysis of 11-nor-Δ 9-tetrahydrocannabinol-9-carboxylic acid in urine specimens</title><author>Weaver, Michael L. ; Gan, Ber K. ; Allen, Ellen ; Diane Baugh, L. ; Liao, Fang-Ying ; Liu, Ray H. ; Langner, Jeffery G. ; Walia, Amrik S. ; Foster Cook, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e1085-e7344c6d5d5b1304f57200d6ce6bb04e166548278e6792baa1125e39ba582a913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Abuscreen</topic><topic>Cannabinoid</topic><topic>Cannabinoids - urine</topic><topic>Dronabinol - analogs & derivatives</topic><topic>Dronabinol - urine</topic><topic>Emit</topic><topic>Fluorescence Polarization Immunoassay</topic><topic>Gas Chromatography-Mass Spectrometry</topic><topic>GC/MS</topic><topic>Humans</topic><topic>Immunoassay</topic><topic>Immunoenzyme Techniques</topic><topic>Marijuana</topic><topic>Predictive Value of Tests</topic><topic>Radioimmunoassay</topic><topic>Reproducibility of Results</topic><topic>TDx</topic><topic>THC</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Weaver, Michael L.</creatorcontrib><creatorcontrib>Gan, Ber K.</creatorcontrib><creatorcontrib>Allen, Ellen</creatorcontrib><creatorcontrib>Diane Baugh, L.</creatorcontrib><creatorcontrib>Liao, Fang-Ying</creatorcontrib><creatorcontrib>Liu, Ray H.</creatorcontrib><creatorcontrib>Langner, Jeffery G.</creatorcontrib><creatorcontrib>Walia, Amrik S.</creatorcontrib><creatorcontrib>Foster Cook, L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Forensic science international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weaver, Michael L.</au><au>Gan, Ber K.</au><au>Allen, Ellen</au><au>Diane Baugh, L.</au><au>Liao, Fang-Ying</au><au>Liu, Ray H.</au><au>Langner, Jeffery G.</au><au>Walia, Amrik S.</au><au>Foster Cook, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlations on radioimmunoassay, fluorescence polarization immunoassay, and enzyme immunoassay of cannabis metabolites with gas chromatography/mass spectrometry analysis of 11-nor-Δ 9-tetrahydrocannabinol-9-carboxylic acid in urine specimens</atitle><jtitle>Forensic science international</jtitle><addtitle>Forensic Sci Int</addtitle><date>1991</date><risdate>1991</risdate><volume>49</volume><issue>1</issue><spage>43</spage><epage>56</epage><pages>43-56</pages><issn>0379-0738</issn><eissn>1872-6283</eissn><abstract>Results obtained from three commercial immunoassay kits, Abuscreen
®, TDx
®, and EMIT
®, commonly used for the initial test of urine cannabinoids (and metabolites) were correlated with the 11-nor-Δ
9-tetrahydrocannabinol-9-carboxylic acid (9-THC-COOH) concentration as determined by GC/MS. Correlation coefficients obtained based on 26 (out of 1359 total sample population) highly relevant samples, are 0.601 and 0.438 for Abuscreen
® and TDx
®. Correlation coefficients obtained from a parallel study on a different set of 47 (out of 5070 total sample population) highly relevant specimens are 0.658 and 0.575 for Abuscreen
® and Emit
®. The immunoassay concentration levels, that correspond to the commonly used 15 ng/ml GC/MS cutoff value for 9-THC-COOH, as calculated from the regression equations are 82 ng/ml and 75 ng/ml for TDx
® and EMIT
® and 120 ng/ml and 72 ng/ml for Abuscreen
® manufactured at two different time periods. The difference of these calculated corresponding concentrations provides quantitative evidence of the reagent specificity differences.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>1851715</pmid><doi>10.1016/0379-0738(91)90170-N</doi><tpages>14</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0379-0738 |
| ispartof | Forensic science international, 1991, Vol.49 (1), p.43-56 |
| issn | 0379-0738 1872-6283 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80563452 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Abuscreen Cannabinoid Cannabinoids - urine Dronabinol - analogs & derivatives Dronabinol - urine Emit Fluorescence Polarization Immunoassay Gas Chromatography-Mass Spectrometry GC/MS Humans Immunoassay Immunoenzyme Techniques Marijuana Predictive Value of Tests Radioimmunoassay Reproducibility of Results TDx THC |
| title | Correlations on radioimmunoassay, fluorescence polarization immunoassay, and enzyme immunoassay of cannabis metabolites with gas chromatography/mass spectrometry analysis of 11-nor-Δ 9-tetrahydrocannabinol-9-carboxylic acid in urine specimens |
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