Key residues involved in calcium-binding motifs in EGF-like domains

Many extracellular proteins with diverse functions contain domains similar to epidermal growth factor (EGF), a number of which have a consensus Asp/Asn, Asp/Asn, Asp*/Asn*, Tyr/Phe (where the asterisk denotes a beta-hydroxylated residue). These include the coagulation factors IX and X, proteins with...

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Veröffentlicht in:	Nature (London) 1991-05, Vol.351 (6322), p.164-167
Hauptverfasser:	Handford, P. A, Mayhew, M, Baron, M, Winship, P. R, Campbell, I. D, Brownlee, G. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino Acids - chemistry Binding Sites - genetics Biochemistry Biological and medical sciences Calcium Calcium - metabolism Calcium-Binding Proteins - genetics Calcium-Binding Proteins - metabolism Carboxylic Acids - metabolism Cloning, Molecular Epidermal Growth Factor - genetics Epidermal Growth Factor - metabolism Fundamental and applied biological sciences. Psychology Hemophilia B - genetics Hemophilia B - metabolism Human factors Humans Ligands Magnetic Resonance Spectroscopy Medical research Miscellaneous Molecular and cellular biology Molecular genetics Molecular Sequence Data Mutation Protein Conformation Proteins Residues
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