Cytogenetic Abnormalities in Uterine Leiomyomata
Uterine leiomyomata are thought to be monoclonal tumors; however, the factors involved in the neoplastic proliferation of uterine leiomyomata are unknown. The purpose of the present study was to characterize uterine leiomyomata using cytogenetic techniques. Thirteen leiomyoma specimens were obtained...
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| Veröffentlicht in: | Obstetrics and gynecology (New York. 1953) 1991-06, Vol.77 (6), p.923-926 |
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| container_title | Obstetrics and gynecology (New York. 1953) |
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| creator | BARBIERI, ROBERT L FRIEDMAN, ANDREW J PAVELKA, KAREN FLETCHER, JONATHAN A MORTON, CYNTHIA C REIN, MITCHELL S |
| description | Uterine leiomyomata are thought to be monoclonal tumors; however, the factors involved in the neoplastic proliferation of uterine leiomyomata are unknown. The purpose of the present study was to characterize uterine leiomyomata using cytogenetic techniques. Thirteen leiomyoma specimens were obtained by hysterectomy or myomectomy. Short-term cultures were successfully established for all specimens, and metaphase spreads were prepared by conventional techniques. Clonal chromosome rearrangements were detected in seven leiomyoma specimens (54%). These rearrangements involved chromosome bands 12ql4-15 in hʼve specimens, including three tumors with a specific translocation, t(12; 14)(ql4-15;q23-24). Chromosome rearrangements involving chromosome band 7q22 were identified in two specimens. A normal 46,XX karyotype was observed in six specimens. Myometrial specimens from two patients with abnormal leiomyoma karyotypes were normal cytogenetically. These results suggest that spontaneous chromosome rearrangements may be responsible for the initiation and proliferation of leiomyoma growth. (Obstet Gynecol 77:923, 1991) |
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The purpose of the present study was to characterize uterine leiomyomata using cytogenetic techniques. Thirteen leiomyoma specimens were obtained by hysterectomy or myomectomy. Short-term cultures were successfully established for all specimens, and metaphase spreads were prepared by conventional techniques. Clonal chromosome rearrangements were detected in seven leiomyoma specimens (54%). These rearrangements involved chromosome bands 12ql4-15 in hʼve specimens, including three tumors with a specific translocation, t(12; 14)(ql4-15;q23-24). Chromosome rearrangements involving chromosome band 7q22 were identified in two specimens. A normal 46,XX karyotype was observed in six specimens. Myometrial specimens from two patients with abnormal leiomyoma karyotypes were normal cytogenetically. These results suggest that spontaneous chromosome rearrangements may be responsible for the initiation and proliferation of leiomyoma growth. (Obstet Gynecol 77:923, 1991)</description><identifier>ISSN: 0029-7844</identifier><identifier>EISSN: 1873-233X</identifier><identifier>PMID: 2030869</identifier><identifier>CODEN: OBGNAS</identifier><language>eng</language><publisher>New York, NY: The American College of Obstetricians and Gynecologists</publisher><subject>Adult ; Biological and medical sciences ; Chromosome Aberrations - genetics ; Chromosome Disorders ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; Humans ; Karyotyping ; Leiomyoma - genetics ; Medical sciences ; Tumors ; Uterine Neoplasms - genetics</subject><ispartof>Obstetrics and gynecology (New York. 1953), 1991-06, Vol.77 (6), p.923-926</ispartof><rights>1991 The American College of Obstetricians and Gynecologists</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19764590$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2030869$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BARBIERI, ROBERT L</creatorcontrib><creatorcontrib>FRIEDMAN, ANDREW J</creatorcontrib><creatorcontrib>PAVELKA, KAREN</creatorcontrib><creatorcontrib>FLETCHER, JONATHAN A</creatorcontrib><creatorcontrib>MORTON, CYNTHIA C</creatorcontrib><creatorcontrib>REIN, MITCHELL S</creatorcontrib><title>Cytogenetic Abnormalities in Uterine Leiomyomata</title><title>Obstetrics and gynecology (New York. 1953)</title><addtitle>Obstet Gynecol</addtitle><description>Uterine leiomyomata are thought to be monoclonal tumors; however, the factors involved in the neoplastic proliferation of uterine leiomyomata are unknown. The purpose of the present study was to characterize uterine leiomyomata using cytogenetic techniques. Thirteen leiomyoma specimens were obtained by hysterectomy or myomectomy. Short-term cultures were successfully established for all specimens, and metaphase spreads were prepared by conventional techniques. Clonal chromosome rearrangements were detected in seven leiomyoma specimens (54%). These rearrangements involved chromosome bands 12ql4-15 in hʼve specimens, including three tumors with a specific translocation, t(12; 14)(ql4-15;q23-24). Chromosome rearrangements involving chromosome band 7q22 were identified in two specimens. A normal 46,XX karyotype was observed in six specimens. Myometrial specimens from two patients with abnormal leiomyoma karyotypes were normal cytogenetically. These results suggest that spontaneous chromosome rearrangements may be responsible for the initiation and proliferation of leiomyoma growth. (Obstet Gynecol 77:923, 1991)</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Chromosome Aberrations - genetics</subject><subject>Chromosome Disorders</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Karyotyping</subject><subject>Leiomyoma - genetics</subject><subject>Medical sciences</subject><subject>Tumors</subject><subject>Uterine Neoplasms - genetics</subject><issn>0029-7844</issn><issn>1873-233X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1Lw0AQhhdRaq3-BCEXvQVmv7K7x1L8goAXC97CZjO1q5ukZhNK_70LDR6GYXgfBp73giypVjxnnH9ekiUAM7nSQlyTmxi_AYAWhi_IggEHXZglgc1p7L-ww9G7bF13_dDa4EePMfNdth1x8B1mJfq-PfWtHe0tudrZEPFu3iuyfX762Lzm5fvL22Zd5gemqcyFQCGUQtbQRskCao5IlQOuUWt0SjpZSy4Y1cicapwQoJ0saspEXe-M4SvyeP57GPrfCeNYtT46DMF22E-x0iBlMpUJvJ_BqW6xqQ6Db-1wqmbFlD_MuY3Oht1gO-fjP0aNKoQ0kDhx5o59SNrxJ0xHHKo92jDuq1QdFExCTo2hUKQrT8Mk_wNjFGk3</recordid><startdate>199106</startdate><enddate>199106</enddate><creator>BARBIERI, ROBERT L</creator><creator>FRIEDMAN, ANDREW J</creator><creator>PAVELKA, KAREN</creator><creator>FLETCHER, JONATHAN A</creator><creator>MORTON, CYNTHIA C</creator><creator>REIN, MITCHELL S</creator><general>The American College of Obstetricians and Gynecologists</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199106</creationdate><title>Cytogenetic Abnormalities in Uterine Leiomyomata</title><author>BARBIERI, ROBERT L ; FRIEDMAN, ANDREW J ; PAVELKA, KAREN ; FLETCHER, JONATHAN A ; MORTON, CYNTHIA C ; REIN, MITCHELL S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p2815-44e4477e2d1d7560b3ee17c038e88ec75c5b534218e2c7dc4408c56b124bbf993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Chromosome Aberrations - genetics</topic><topic>Chromosome Disorders</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Karyotyping</topic><topic>Leiomyoma - genetics</topic><topic>Medical sciences</topic><topic>Tumors</topic><topic>Uterine Neoplasms - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BARBIERI, ROBERT L</creatorcontrib><creatorcontrib>FRIEDMAN, ANDREW J</creatorcontrib><creatorcontrib>PAVELKA, KAREN</creatorcontrib><creatorcontrib>FLETCHER, JONATHAN A</creatorcontrib><creatorcontrib>MORTON, CYNTHIA C</creatorcontrib><creatorcontrib>REIN, MITCHELL S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BARBIERI, ROBERT L</au><au>FRIEDMAN, ANDREW J</au><au>PAVELKA, KAREN</au><au>FLETCHER, JONATHAN A</au><au>MORTON, CYNTHIA C</au><au>REIN, MITCHELL S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytogenetic Abnormalities in Uterine Leiomyomata</atitle><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle><addtitle>Obstet Gynecol</addtitle><date>1991-06</date><risdate>1991</risdate><volume>77</volume><issue>6</issue><spage>923</spage><epage>926</epage><pages>923-926</pages><issn>0029-7844</issn><eissn>1873-233X</eissn><coden>OBGNAS</coden><abstract>Uterine leiomyomata are thought to be monoclonal tumors; however, the factors involved in the neoplastic proliferation of uterine leiomyomata are unknown. The purpose of the present study was to characterize uterine leiomyomata using cytogenetic techniques. Thirteen leiomyoma specimens were obtained by hysterectomy or myomectomy. Short-term cultures were successfully established for all specimens, and metaphase spreads were prepared by conventional techniques. Clonal chromosome rearrangements were detected in seven leiomyoma specimens (54%). These rearrangements involved chromosome bands 12ql4-15 in hʼve specimens, including three tumors with a specific translocation, t(12; 14)(ql4-15;q23-24). Chromosome rearrangements involving chromosome band 7q22 were identified in two specimens. A normal 46,XX karyotype was observed in six specimens. Myometrial specimens from two patients with abnormal leiomyoma karyotypes were normal cytogenetically. These results suggest that spontaneous chromosome rearrangements may be responsible for the initiation and proliferation of leiomyoma growth. (Obstet Gynecol 77:923, 1991)</abstract><cop>New York, NY</cop><pub>The American College of Obstetricians and Gynecologists</pub><pmid>2030869</pmid><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0029-7844 |
| ispartof | Obstetrics and gynecology (New York. 1953), 1991-06, Vol.77 (6), p.923-926 |
| issn | 0029-7844 1873-233X |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Biological and medical sciences Chromosome Aberrations - genetics Chromosome Disorders Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Karyotyping Leiomyoma - genetics Medical sciences Tumors Uterine Neoplasms - genetics |
| title | Cytogenetic Abnormalities in Uterine Leiomyomata |
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