Postmortem digoxin tissue concentration and organ content in infancy and childhood
The concentration of digoxin in tissues and the content of the drug in various organs are reported in 36 infants and children. Sixteen received the drug on a short-term basis and 20 on a long-term basis. The drug was given intravenously to 12, orally to 17, and by intramuscular injection to 7. The s...
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Veröffentlicht in: | The American journal of cardiology 1983-08, Vol.52 (3), p.330-335 |
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description | The concentration of digoxin in tissues and the content of the drug in various organs are reported in 36 infants and children. Sixteen received the drug on a short-term basis and 20 on a long-term basis. The drug was given intravenously to 12, orally to 17, and by intramuscular injection to 7. The study was conducted to determine distribution of digoxin in infants and children and to examine the forensic implications related to digoxin overdosage. Upper therapeutic concentration thresholds for digoxin were established in various tissues. These are different for preterm and full-term neonates than for older children and adults; for example, adult and neonatal values for postmortem blood specimens are 8 and 15 ng/ml, and for ventricular myocardium are 250 and 450 ng/g, respectively. The chronically digitalized premature infant retains in most tissues a considerably larger fraction of digoxin than more mature infants and children. This is in accord with previously demonstrated lower renal digoxin levels in premature infants attributed to their reduced ability to excrete this drug. |
doi_str_mv | 10.1016/0002-9149(83)90133-9 |
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Sixteen received the drug on a short-term basis and 20 on a long-term basis. The drug was given intravenously to 12, orally to 17, and by intramuscular injection to 7. The study was conducted to determine distribution of digoxin in infants and children and to examine the forensic implications related to digoxin overdosage. Upper therapeutic concentration thresholds for digoxin were established in various tissues. These are different for preterm and full-term neonates than for older children and adults; for example, adult and neonatal values for postmortem blood specimens are 8 and 15 ng/ml, and for ventricular myocardium are 250 and 450 ng/g, respectively. The chronically digitalized premature infant retains in most tissues a considerably larger fraction of digoxin than more mature infants and children. This is in accord with previously demonstrated lower renal digoxin levels in premature infants attributed to their reduced ability to excrete this drug.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/0002-9149(83)90133-9</identifier><identifier>PMID: 6869282</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Child ; Child, Preschool ; Digoxin - analysis ; Forensic Medicine ; Heart Failure - drug therapy ; Heart Failure - mortality ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Tissue Distribution</subject><ispartof>The American journal of cardiology, 1983-08, Vol.52 (3), p.330-335</ispartof><rights>1983</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-1a97a23cdc2d1100e5ffc12d8428c4b4de6c874ecf9a8c125022f7e597f5d91f3</citedby><cites>FETCH-LOGICAL-c357t-1a97a23cdc2d1100e5ffc12d8428c4b4de6c874ecf9a8c125022f7e597f5d91f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0002-9149(83)90133-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6869282$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hastreiter, Alois R.</creatorcontrib><creatorcontrib>Van Der Horst, Ronald L.</creatorcontrib><title>Postmortem digoxin tissue concentration and organ content in infancy and childhood</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>The concentration of digoxin in tissues and the content of the drug in various organs are reported in 36 infants and children. Sixteen received the drug on a short-term basis and 20 on a long-term basis. The drug was given intravenously to 12, orally to 17, and by intramuscular injection to 7. The study was conducted to determine distribution of digoxin in infants and children and to examine the forensic implications related to digoxin overdosage. Upper therapeutic concentration thresholds for digoxin were established in various tissues. These are different for preterm and full-term neonates than for older children and adults; for example, adult and neonatal values for postmortem blood specimens are 8 and 15 ng/ml, and for ventricular myocardium are 250 and 450 ng/g, respectively. The chronically digitalized premature infant retains in most tissues a considerably larger fraction of digoxin than more mature infants and children. This is in accord with previously demonstrated lower renal digoxin levels in premature infants attributed to their reduced ability to excrete this drug.</description><subject>Adolescent</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Digoxin - analysis</subject><subject>Forensic Medicine</subject><subject>Heart Failure - drug therapy</subject><subject>Heart Failure - mortality</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Tissue Distribution</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMoWj_-gcKeRA-rSXazm1wEKX6BoIieQ0wmbaSbaJKK_femtvToaZh533eGeRA6JviCYNJdYoxpLUgrznhzLjBpmlpsoRHhvaiJIM02Gm0se2g_pY_SEsK6XbTb8U5QTkfo5TmkPISYYaiMm4Qf56vsUppDpYPX4HNU2QVfKW-qECfKL-e5zKvidN4qrxd_op66mZmGYA7RjlWzBEfreoDebm9ex_f149Pdw_j6sdYN63NNlOgVbbTR1BCCMTBrNaGGt5Tr9r010Gnet6CtULwIDFNqe2Cit8wIYpsDdLra-xnD1xxSloNLGmYz5SHMk-SYMdZ3rBjblVHHkFIEKz-jG1RcSILlEqVccpJLTpI38g-lFCV2st4_fx_AbEJrdkW_WulQnvx2EGXSDgoz4yLoLE1w_x_4BbjVg-0</recordid><startdate>198308</startdate><enddate>198308</enddate><creator>Hastreiter, Alois R.</creator><creator>Van Der Horst, Ronald L.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198308</creationdate><title>Postmortem digoxin tissue concentration and organ content in infancy and childhood</title><author>Hastreiter, Alois R. ; Van Der Horst, Ronald L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-1a97a23cdc2d1100e5ffc12d8428c4b4de6c874ecf9a8c125022f7e597f5d91f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Adolescent</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Digoxin - analysis</topic><topic>Forensic Medicine</topic><topic>Heart Failure - drug therapy</topic><topic>Heart Failure - mortality</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hastreiter, Alois R.</creatorcontrib><creatorcontrib>Van Der Horst, Ronald L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hastreiter, Alois R.</au><au>Van Der Horst, Ronald L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Postmortem digoxin tissue concentration and organ content in infancy and childhood</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>1983-08</date><risdate>1983</risdate><volume>52</volume><issue>3</issue><spage>330</spage><epage>335</epage><pages>330-335</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><abstract>The concentration of digoxin in tissues and the content of the drug in various organs are reported in 36 infants and children. Sixteen received the drug on a short-term basis and 20 on a long-term basis. The drug was given intravenously to 12, orally to 17, and by intramuscular injection to 7. The study was conducted to determine distribution of digoxin in infants and children and to examine the forensic implications related to digoxin overdosage. Upper therapeutic concentration thresholds for digoxin were established in various tissues. These are different for preterm and full-term neonates than for older children and adults; for example, adult and neonatal values for postmortem blood specimens are 8 and 15 ng/ml, and for ventricular myocardium are 250 and 450 ng/g, respectively. The chronically digitalized premature infant retains in most tissues a considerably larger fraction of digoxin than more mature infants and children. This is in accord with previously demonstrated lower renal digoxin levels in premature infants attributed to their reduced ability to excrete this drug.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>6869282</pmid><doi>10.1016/0002-9149(83)90133-9</doi><tpages>6</tpages></addata></record> |
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subjects | Adolescent Child Child, Preschool Digoxin - analysis Forensic Medicine Heart Failure - drug therapy Heart Failure - mortality Humans Infant Infant, Newborn Infant, Premature Tissue Distribution |
title | Postmortem digoxin tissue concentration and organ content in infancy and childhood |
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