Impairment of Endothelium-Dependent Pulmonary-Artery Relaxation in Chronic Obstructive Lung Disease

CHRONIC obstructive lung disease causing hypoxemia leads to the development of pulmonary hypertension and cor pulmonale. 1 The prognosis of cor pulmonale is determined by the severity of the pulmonary hypertension. 2 However, the manner in which prolonged alveolar hypoxia causes chronic pulmonary hy...

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Veröffentlicht in:	The New England journal of medicine 1991-05, Vol.324 (22), p.1539-1547
Hauptverfasser:	Dinh-Xuan, A. Tuan, Higenbottam, Timothy W, Clelland, Colin A, Pepke-Zaba, Joanna, Cremona, George, Butt, A. Yazdani, Large, Stephen R, Wells, Francis C, Wallwork, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine Acetylcholine - pharmacology Adenosine Adenosine diphosphate Adenosine Diphosphate - pharmacology Adolescent Adult Aged Arginine Arginine - analogs & derivatives Arginine - pharmacology Biological and medical sciences Blood pressure Carbon dioxide Cardiovascular disease Chronic illnesses Chronic obstructive pulmonary disease Chronic obstructive pulmonary disease, asthma Cystic fibrosis Endothelial cells Endothelium Endothelium, Vascular - physiology Female Humans Hypertension Hypoxia In Vitro Techniques Lung carcinoma Lung diseases Lung Diseases, Obstructive - pathology Lung Diseases, Obstructive - physiopathology Lung transplantation Lungs Male Medical sciences Middle Aged Monomethyl-L-arginine Nitric oxide Nitric Oxide - physiology Nitroprusside - pharmacology Obstructive lung disease omega-N-Methylarginine Phenylephrine Phenylephrine - pharmacology Physiology Pneumology Pulmonary arteries Pulmonary artery Pulmonary Artery - drug effects Pulmonary Artery - pathology Pulmonary Artery - physiopathology Pulmonary hypertension Rodents Sodium Sodium nitroprusside Surgery Thoracic surgery Transplantation Vasodilation - physiology Vasodilators
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