Galactocerebrosides are antigens for immunoglobulins in sera of an experimental model of trypanosomiasis in sheep
In an experimental model of human African trypanosomiasis in sheep inoculated with Trypanosoma brucei brucei, we report an immunoglobulin reactivity towards central nervous system (CNS) glycolipids. Immunocharacterization of the glycolipid antigens was performed on thin-layer chromatography using pe...
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| Veröffentlicht in: | Journal of the neurological sciences 1991, Vol.101 (1), p.82-86 |
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| container_title | Journal of the neurological sciences |
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| creator | Jauberteau, Marie-Odile Younes-Chennoufi, Aména Ben Amevigbe, Martin Bouteille, Bernard Dumas, Michel Breton, Jean-Christian Baumann, Nicole |
| description | In an experimental model of human African trypanosomiasis in sheep inoculated with
Trypanosoma brucei brucei, we report an immunoglobulin reactivity towards central nervous system (CNS) glycolipids. Immunocharacterization of the glycolipid antigens was performed on thin-layer chromatography using peroxidase-labelled second antibody. An immunoreactivity against galactocerebroside antigens was observed in inoculated animals up to a dilution of 1 : 600 and was suppressed after immunoadsorption of sera on pure galactocerebrosides. As galactocerebroside antigen is responsible for demyelination in several experimental models, the relation between the important glycolipid immunoreactivity in inoculated sheep sera and the pathogenesis of CNS demyelination in African trypanosomiasis is suggested. |
| doi_str_mv | 10.1016/0022-510X(91)90020-8 |
| format | Article |
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Trypanosoma brucei brucei, we report an immunoglobulin reactivity towards central nervous system (CNS) glycolipids. Immunocharacterization of the glycolipid antigens was performed on thin-layer chromatography using peroxidase-labelled second antibody. An immunoreactivity against galactocerebroside antigens was observed in inoculated animals up to a dilution of 1 : 600 and was suppressed after immunoadsorption of sera on pure galactocerebrosides. As galactocerebroside antigen is responsible for demyelination in several experimental models, the relation between the important glycolipid immunoreactivity in inoculated sheep sera and the pathogenesis of CNS demyelination in African trypanosomiasis is suggested.</description><identifier>ISSN: 0022-510X</identifier><identifier>EISSN: 1878-5883</identifier><identifier>DOI: 10.1016/0022-510X(91)90020-8</identifier><identifier>PMID: 2027031</identifier><identifier>CODEN: JNSCAG</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>African trypanosomiasis ; Animals ; Antibodies ; Antigen-Antibody Complex ; Biological and medical sciences ; Disease Models, Animal ; Galactocerebrosides ; Galactosylceramides - immunology ; Galactosylceramides - isolation & purification ; Immunoglobulin M - immunology ; Immunoglobulins - immunology ; Infectious diseases ; Medical sciences ; Mice ; Parasitic diseases ; Reference Values ; Sheep ; Trypanosoma brucei brucei - immunology ; Trypanosomiasis, African - blood ; Trypanosomiasis, African - immunology</subject><ispartof>Journal of the neurological sciences, 1991, Vol.101 (1), p.82-86</ispartof><rights>1991</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-557d01edc9fe487fc7576a229646d0a7e3db6223cd39a6e768bf359b29e6a7cb3</citedby><cites>FETCH-LOGICAL-c417t-557d01edc9fe487fc7576a229646d0a7e3db6223cd39a6e768bf359b29e6a7cb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0022510X91900208$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4485428$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2027031$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jauberteau, Marie-Odile</creatorcontrib><creatorcontrib>Younes-Chennoufi, Aména Ben</creatorcontrib><creatorcontrib>Amevigbe, Martin</creatorcontrib><creatorcontrib>Bouteille, Bernard</creatorcontrib><creatorcontrib>Dumas, Michel</creatorcontrib><creatorcontrib>Breton, Jean-Christian</creatorcontrib><creatorcontrib>Baumann, Nicole</creatorcontrib><title>Galactocerebrosides are antigens for immunoglobulins in sera of an experimental model of trypanosomiasis in sheep</title><title>Journal of the neurological sciences</title><addtitle>J Neurol Sci</addtitle><description>In an experimental model of human African trypanosomiasis in sheep inoculated with
Trypanosoma brucei brucei, we report an immunoglobulin reactivity towards central nervous system (CNS) glycolipids. Immunocharacterization of the glycolipid antigens was performed on thin-layer chromatography using peroxidase-labelled second antibody. An immunoreactivity against galactocerebroside antigens was observed in inoculated animals up to a dilution of 1 : 600 and was suppressed after immunoadsorption of sera on pure galactocerebrosides. As galactocerebroside antigen is responsible for demyelination in several experimental models, the relation between the important glycolipid immunoreactivity in inoculated sheep sera and the pathogenesis of CNS demyelination in African trypanosomiasis is suggested.</description><subject>African trypanosomiasis</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Antigen-Antibody Complex</subject><subject>Biological and medical sciences</subject><subject>Disease Models, Animal</subject><subject>Galactocerebrosides</subject><subject>Galactosylceramides - immunology</subject><subject>Galactosylceramides - isolation & purification</subject><subject>Immunoglobulin M - immunology</subject><subject>Immunoglobulins - immunology</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Parasitic diseases</subject><subject>Reference Values</subject><subject>Sheep</subject><subject>Trypanosoma brucei brucei - immunology</subject><subject>Trypanosomiasis, African - blood</subject><subject>Trypanosomiasis, African - immunology</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9rFTEUxYMo9bX6DRRmIVIXU5NM_m4KUrQVCt0ouAuZ5E6NzCTTZEbab2_G93hLXYXk_M7l5hyE3hB8QTARHzGmtOUE_zjX5IOuN9yqZ2hHlFQtV6p7jnZH5CU6LeUXxlgopU_QCcVU4o7s0MO1Ha1bkoMMfU4leCiNzdDYuIR7iKUZUm7CNK0x3Y-pX8dQ30JsCmTbpKFyDTzOkMMEcbFjMyUP4yYs-Wm2MZU0BVvC3vMTYH6FXgx2LPD6cJ6h718-f7u6aW_vrr9efbptHSNyaTmXHhPwTg_AlByc5FJYSrVgwmMrofO9oLRzvtNWgBSqHzque6pBWOn67gy938-dc3pYoSxmCsXBONoIaS1GYc4p1t1_QVLDxAyzCrI96GpQJcNg5vptm58MwWarxGx5my1vo4n5W4lR1fb2MH_tJ_BH06GDqr876LY4Ow7ZRhfKEWNMcUa3MZd7DGpovwNkU1yA6MCHDG4xPoV_7_EHyAapvg</recordid><startdate>1991</startdate><enddate>1991</enddate><creator>Jauberteau, Marie-Odile</creator><creator>Younes-Chennoufi, Aména Ben</creator><creator>Amevigbe, Martin</creator><creator>Bouteille, Bernard</creator><creator>Dumas, Michel</creator><creator>Breton, Jean-Christian</creator><creator>Baumann, Nicole</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>1991</creationdate><title>Galactocerebrosides are antigens for immunoglobulins in sera of an experimental model of trypanosomiasis in sheep</title><author>Jauberteau, Marie-Odile ; Younes-Chennoufi, Aména Ben ; Amevigbe, Martin ; Bouteille, Bernard ; Dumas, Michel ; Breton, Jean-Christian ; Baumann, Nicole</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-557d01edc9fe487fc7576a229646d0a7e3db6223cd39a6e768bf359b29e6a7cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>African trypanosomiasis</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Antigen-Antibody Complex</topic><topic>Biological and medical sciences</topic><topic>Disease Models, Animal</topic><topic>Galactocerebrosides</topic><topic>Galactosylceramides - immunology</topic><topic>Galactosylceramides - isolation & purification</topic><topic>Immunoglobulin M - immunology</topic><topic>Immunoglobulins - immunology</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Parasitic diseases</topic><topic>Reference Values</topic><topic>Sheep</topic><topic>Trypanosoma brucei brucei - immunology</topic><topic>Trypanosomiasis, African - blood</topic><topic>Trypanosomiasis, African - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jauberteau, Marie-Odile</creatorcontrib><creatorcontrib>Younes-Chennoufi, Aména Ben</creatorcontrib><creatorcontrib>Amevigbe, Martin</creatorcontrib><creatorcontrib>Bouteille, Bernard</creatorcontrib><creatorcontrib>Dumas, Michel</creatorcontrib><creatorcontrib>Breton, Jean-Christian</creatorcontrib><creatorcontrib>Baumann, Nicole</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jauberteau, Marie-Odile</au><au>Younes-Chennoufi, Aména Ben</au><au>Amevigbe, Martin</au><au>Bouteille, Bernard</au><au>Dumas, Michel</au><au>Breton, Jean-Christian</au><au>Baumann, Nicole</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Galactocerebrosides are antigens for immunoglobulins in sera of an experimental model of trypanosomiasis in sheep</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>1991</date><risdate>1991</risdate><volume>101</volume><issue>1</issue><spage>82</spage><epage>86</epage><pages>82-86</pages><issn>0022-510X</issn><eissn>1878-5883</eissn><coden>JNSCAG</coden><abstract>In an experimental model of human African trypanosomiasis in sheep inoculated with
Trypanosoma brucei brucei, we report an immunoglobulin reactivity towards central nervous system (CNS) glycolipids. Immunocharacterization of the glycolipid antigens was performed on thin-layer chromatography using peroxidase-labelled second antibody. An immunoreactivity against galactocerebroside antigens was observed in inoculated animals up to a dilution of 1 : 600 and was suppressed after immunoadsorption of sera on pure galactocerebrosides. As galactocerebroside antigen is responsible for demyelination in several experimental models, the relation between the important glycolipid immunoreactivity in inoculated sheep sera and the pathogenesis of CNS demyelination in African trypanosomiasis is suggested.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>2027031</pmid><doi>10.1016/0022-510X(91)90020-8</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of the neurological sciences, 1991, Vol.101 (1), p.82-86 |
| issn | 0022-510X 1878-5883 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | African trypanosomiasis Animals Antibodies Antigen-Antibody Complex Biological and medical sciences Disease Models, Animal Galactocerebrosides Galactosylceramides - immunology Galactosylceramides - isolation & purification Immunoglobulin M - immunology Immunoglobulins - immunology Infectious diseases Medical sciences Mice Parasitic diseases Reference Values Sheep Trypanosoma brucei brucei - immunology Trypanosomiasis, African - blood Trypanosomiasis, African - immunology |
| title | Galactocerebrosides are antigens for immunoglobulins in sera of an experimental model of trypanosomiasis in sheep |
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