Central and peripheral components of dermorphin's effect on rat intestinal propulsion in comparison to morphine

Dermorphin, injected intracerebroventricularly (ICV) to rats, provokes, like to morphine, an inhibition of intestinal propulsion linearly related to the log of the administered doses (in the range from 0.06 to 0.56 μg/rat), but it is 143 times more active than morphine. Naloxone, ICV or IP, antagoni...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1983, Vol.4 (1), p.55-58
Hauptverfasser:	Parolaro, D., Sala, M., Crema, G., Spazzi, L., Cesana, R., Gori, E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dermorphin Gastrointestinal Motility - drug effects Injections, Intraperitoneal Injections, Intraventricular Intestinal motility Intestines - innervation Male Morphine Morphine - pharmacology Naloxone Oligopeptides - administration & dosage Oligopeptides - pharmacology Opioid Peptides Quaternary naloxone Rats Rats, Inbred Strains
Online-Zugang:	Volltext
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