Central and peripheral components of dermorphin's effect on rat intestinal propulsion in comparison to morphine
Dermorphin, injected intracerebroventricularly (ICV) to rats, provokes, like to morphine, an inhibition of intestinal propulsion linearly related to the log of the administered doses (in the range from 0.06 to 0.56 μg/rat), but it is 143 times more active than morphine. Naloxone, ICV or IP, antagoni...
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| Veröffentlicht in: | Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1983, Vol.4 (1), p.55-58 |
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| container_title | Peptides (New York, N.Y. : 1980) |
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| creator | Parolaro, D. Sala, M. Crema, G. Spazzi, L. Cesana, R. Gori, E. |
| description | Dermorphin, injected intracerebroventricularly (ICV) to rats, provokes, like to morphine, an inhibition of intestinal propulsion linearly related to the log of the administered doses (in the range from 0.06 to 0.56 μg/rat), but it is 143 times more active than morphine. Naloxone, ICV or IP, antagonizes dermorphin less effectively than morphine. Quaternary naloxone ICV administered antagonizes the intestinal effect of ICV dermorphin, while IP administered it is not effective until 8 mg/kg. The dose of dermorphin maximally active by the ICV route (0.56 μg/rat) is completely inactive when injected IP. Increasing doses of dermorphin IP (from 12 to 6400 μg/kg) inhibit intestinal propulsion to the same extent irrespectively of the doses employed, but never by more than 50%. Only a high dose of naloxone (30 mg/kg/IP) antagonizes this IP effect. The central and peripheral components of this intestinal effect of dermorphin are discussed. |
| doi_str_mv | 10.1016/0196-9781(83)90165-1 |
| format | Article |
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Naloxone, ICV or IP, antagonizes dermorphin less effectively than morphine. Quaternary naloxone ICV administered antagonizes the intestinal effect of ICV dermorphin, while IP administered it is not effective until 8 mg/kg. The dose of dermorphin maximally active by the ICV route (0.56 μg/rat) is completely inactive when injected IP. Increasing doses of dermorphin IP (from 12 to 6400 μg/kg) inhibit intestinal propulsion to the same extent irrespectively of the doses employed, but never by more than 50%. Only a high dose of naloxone (30 mg/kg/IP) antagonizes this IP effect. The central and peripheral components of this intestinal effect of dermorphin are discussed.</description><identifier>ISSN: 0196-9781</identifier><identifier>EISSN: 1873-5169</identifier><identifier>DOI: 10.1016/0196-9781(83)90165-1</identifier><identifier>PMID: 6866810</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Dermorphin ; Gastrointestinal Motility - drug effects ; Injections, Intraperitoneal ; Injections, Intraventricular ; Intestinal motility ; Intestines - innervation ; Male ; Morphine ; Morphine - pharmacology ; Naloxone ; Oligopeptides - administration & dosage ; Oligopeptides - pharmacology ; Opioid Peptides ; Quaternary naloxone ; Rats ; Rats, Inbred Strains</subject><ispartof>Peptides (New York, N.Y. : 1980), 1983, Vol.4 (1), p.55-58</ispartof><rights>1983</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-714a613447b927ef477478bb5f9fe1966c3b64a93b7375b515cc02be36281b6c3</citedby><cites>FETCH-LOGICAL-c388t-714a613447b927ef477478bb5f9fe1966c3b64a93b7375b515cc02be36281b6c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0196-9781(83)90165-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6866810$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Parolaro, D.</creatorcontrib><creatorcontrib>Sala, M.</creatorcontrib><creatorcontrib>Crema, G.</creatorcontrib><creatorcontrib>Spazzi, L.</creatorcontrib><creatorcontrib>Cesana, R.</creatorcontrib><creatorcontrib>Gori, E.</creatorcontrib><title>Central and peripheral components of dermorphin's effect on rat intestinal propulsion in comparison to morphine</title><title>Peptides (New York, N.Y. : 1980)</title><addtitle>Peptides</addtitle><description>Dermorphin, injected intracerebroventricularly (ICV) to rats, provokes, like to morphine, an inhibition of intestinal propulsion linearly related to the log of the administered doses (in the range from 0.06 to 0.56 μg/rat), but it is 143 times more active than morphine. Naloxone, ICV or IP, antagonizes dermorphin less effectively than morphine. Quaternary naloxone ICV administered antagonizes the intestinal effect of ICV dermorphin, while IP administered it is not effective until 8 mg/kg. The dose of dermorphin maximally active by the ICV route (0.56 μg/rat) is completely inactive when injected IP. Increasing doses of dermorphin IP (from 12 to 6400 μg/kg) inhibit intestinal propulsion to the same extent irrespectively of the doses employed, but never by more than 50%. Only a high dose of naloxone (30 mg/kg/IP) antagonizes this IP effect. The central and peripheral components of this intestinal effect of dermorphin are discussed.</description><subject>Animals</subject><subject>Dermorphin</subject><subject>Gastrointestinal Motility - drug effects</subject><subject>Injections, Intraperitoneal</subject><subject>Injections, Intraventricular</subject><subject>Intestinal motility</subject><subject>Intestines - innervation</subject><subject>Male</subject><subject>Morphine</subject><subject>Morphine - pharmacology</subject><subject>Naloxone</subject><subject>Oligopeptides - administration & dosage</subject><subject>Oligopeptides - pharmacology</subject><subject>Opioid Peptides</subject><subject>Quaternary naloxone</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><issn>0196-9781</issn><issn>1873-5169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUctuGyEURVUr13HyB63EKk0Wk4JhgNlEiqzmIVnKJl0jYO7IVDMwhXGk_n2Y2PIyXaHLeXA5B6FvlNxQQsVPQhtRNVLRK8Wum3JTV_QTWlIlWVVT0XxGyxPlKzrL-Q8hhPNGLdBCKCEUJUsUNxCmZHpsQotHSH7cwTy6OIwxFCzj2OEW0hDTuPPhR8bQdeAmHANOZsI-TJAnH4pmTHHc99kXxId3B5N8LtMU8VEO5-hLZ_oMF8dzhX7f_3rZPFbb54enzd22ckypqZKUG0EZ59I2awkdl5JLZW3dNR2UTwnHrOCmYVYyWdua1s6RtQUm1oragq7Q5cG3LPV3XzbUg88O-t4EiPusFam5pDX5L5EyJQhjshD5gehSzDlBp8fkB5P-aUr0XIie09Zz2lox_V5IUa_Q96P_3g7QnkTHBgp-e8ChpPHqIensPAQHrU8lZt1G__EDb_Lim2Y</recordid><startdate>1983</startdate><enddate>1983</enddate><creator>Parolaro, D.</creator><creator>Sala, M.</creator><creator>Crema, G.</creator><creator>Spazzi, L.</creator><creator>Cesana, R.</creator><creator>Gori, E.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>1983</creationdate><title>Central and peripheral components of dermorphin's effect on rat intestinal propulsion in comparison to morphine</title><author>Parolaro, D. ; Sala, M. ; Crema, G. ; Spazzi, L. ; Cesana, R. ; Gori, E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-714a613447b927ef477478bb5f9fe1966c3b64a93b7375b515cc02be36281b6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Animals</topic><topic>Dermorphin</topic><topic>Gastrointestinal Motility - drug effects</topic><topic>Injections, Intraperitoneal</topic><topic>Injections, Intraventricular</topic><topic>Intestinal motility</topic><topic>Intestines - innervation</topic><topic>Male</topic><topic>Morphine</topic><topic>Morphine - pharmacology</topic><topic>Naloxone</topic><topic>Oligopeptides - administration & dosage</topic><topic>Oligopeptides - pharmacology</topic><topic>Opioid Peptides</topic><topic>Quaternary naloxone</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Parolaro, D.</creatorcontrib><creatorcontrib>Sala, M.</creatorcontrib><creatorcontrib>Crema, G.</creatorcontrib><creatorcontrib>Spazzi, L.</creatorcontrib><creatorcontrib>Cesana, R.</creatorcontrib><creatorcontrib>Gori, E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Peptides (New York, N.Y. : 1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Parolaro, D.</au><au>Sala, M.</au><au>Crema, G.</au><au>Spazzi, L.</au><au>Cesana, R.</au><au>Gori, E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Central and peripheral components of dermorphin's effect on rat intestinal propulsion in comparison to morphine</atitle><jtitle>Peptides (New York, N.Y. : 1980)</jtitle><addtitle>Peptides</addtitle><date>1983</date><risdate>1983</risdate><volume>4</volume><issue>1</issue><spage>55</spage><epage>58</epage><pages>55-58</pages><issn>0196-9781</issn><eissn>1873-5169</eissn><abstract>Dermorphin, injected intracerebroventricularly (ICV) to rats, provokes, like to morphine, an inhibition of intestinal propulsion linearly related to the log of the administered doses (in the range from 0.06 to 0.56 μg/rat), but it is 143 times more active than morphine. Naloxone, ICV or IP, antagonizes dermorphin less effectively than morphine. Quaternary naloxone ICV administered antagonizes the intestinal effect of ICV dermorphin, while IP administered it is not effective until 8 mg/kg. The dose of dermorphin maximally active by the ICV route (0.56 μg/rat) is completely inactive when injected IP. Increasing doses of dermorphin IP (from 12 to 6400 μg/kg) inhibit intestinal propulsion to the same extent irrespectively of the doses employed, but never by more than 50%. Only a high dose of naloxone (30 mg/kg/IP) antagonizes this IP effect. The central and peripheral components of this intestinal effect of dermorphin are discussed.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>6866810</pmid><doi>10.1016/0196-9781(83)90165-1</doi><tpages>4</tpages></addata></record> |
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| ispartof | Peptides (New York, N.Y. : 1980), 1983, Vol.4 (1), p.55-58 |
| issn | 0196-9781 1873-5169 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Dermorphin Gastrointestinal Motility - drug effects Injections, Intraperitoneal Injections, Intraventricular Intestinal motility Intestines - innervation Male Morphine Morphine - pharmacology Naloxone Oligopeptides - administration & dosage Oligopeptides - pharmacology Opioid Peptides Quaternary naloxone Rats Rats, Inbred Strains |
| title | Central and peripheral components of dermorphin's effect on rat intestinal propulsion in comparison to morphine |
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