Naturally occurring benzodiazepines in human milk
The presence of benzodiazepine-like molecules was detected radioimmunologically in the plasma and milk of 12 women and in the plasma of 9 men. All subjects were non-users of benzodiazepines. The concentration of these biological materials expressed as diazepam equivalents per mL amounted to 2.54 ± 0...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1991-03, Vol.175 (3), p.1042-1050 |
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| container_title | Biochemical and biophysical research communications |
| container_volume | 175 |
| creator | Peña, C. Medina, J.H. Piva, M. Diaz, L.E. Danilowicz, C. Paladini, A.C. |
| description | The presence of benzodiazepine-like molecules was detected radioimmunologically in the plasma and milk of 12 women and in the plasma of 9 men. All subjects were non-users of benzodiazepines.
The concentration of these biological materials expressed as diazepam equivalents per mL amounted to 2.54 ± 0.74 ng in male plasma; to 2.20 ± 0.35 ng in female plasma and to 1.91 ± 0.54 ng in milk. Further investigation of the active compounds in milk permitted the unequivocal identification of diazepam, both free and bound to a presumably protein carrier and, at least, three more benzodiazepine-like molecules. Their origin either from dietary sources or as a result of endogenous biosynthesis is still unclear. |
| doi_str_mv | 10.1016/0006-291X(91)91670-8 |
| format | Article |
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The concentration of these biological materials expressed as diazepam equivalents per mL amounted to 2.54 ± 0.74 ng in male plasma; to 2.20 ± 0.35 ng in female plasma and to 1.91 ± 0.54 ng in milk. Further investigation of the active compounds in milk permitted the unequivocal identification of diazepam, both free and bound to a presumably protein carrier and, at least, three more benzodiazepine-like molecules. Their origin either from dietary sources or as a result of endogenous biosynthesis is still unclear.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/0006-291X(91)91670-8</identifier><identifier>PMID: 2025236</identifier><identifier>CODEN: BBRCA9</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Analytical, structural and metabolic biochemistry ; Aromatic and heterocyclic compounds ; Benzodiazepines - analysis ; Benzodiazepines - blood ; Biological and medical sciences ; Chromatography, High Pressure Liquid ; Female ; Fundamental and applied biological sciences. Psychology ; Heterocyclic compounds, pigments ; Humans ; Male ; Mass Spectrometry ; Milk, Human - chemistry ; Other biological molecules ; Pregnancy ; Radioligand Assay ; Reference Values</subject><ispartof>Biochemical and biophysical research communications, 1991-03, Vol.175 (3), p.1042-1050</ispartof><rights>1991</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-7d44589e8701dea3852633ef1fa96fde3d811b6326c8ac9853d578b91df1781c3</citedby><cites>FETCH-LOGICAL-c387t-7d44589e8701dea3852633ef1fa96fde3d811b6326c8ac9853d578b91df1781c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-291X(91)91670-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19661561$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2025236$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peña, C.</creatorcontrib><creatorcontrib>Medina, J.H.</creatorcontrib><creatorcontrib>Piva, M.</creatorcontrib><creatorcontrib>Diaz, L.E.</creatorcontrib><creatorcontrib>Danilowicz, C.</creatorcontrib><creatorcontrib>Paladini, A.C.</creatorcontrib><title>Naturally occurring benzodiazepines in human milk</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>The presence of benzodiazepine-like molecules was detected radioimmunologically in the plasma and milk of 12 women and in the plasma of 9 men. All subjects were non-users of benzodiazepines.
The concentration of these biological materials expressed as diazepam equivalents per mL amounted to 2.54 ± 0.74 ng in male plasma; to 2.20 ± 0.35 ng in female plasma and to 1.91 ± 0.54 ng in milk. Further investigation of the active compounds in milk permitted the unequivocal identification of diazepam, both free and bound to a presumably protein carrier and, at least, three more benzodiazepine-like molecules. Their origin either from dietary sources or as a result of endogenous biosynthesis is still unclear.</description><subject>Analytical, structural and metabolic biochemistry</subject><subject>Aromatic and heterocyclic compounds</subject><subject>Benzodiazepines - analysis</subject><subject>Benzodiazepines - blood</subject><subject>Biological and medical sciences</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heterocyclic compounds, pigments</subject><subject>Humans</subject><subject>Male</subject><subject>Mass Spectrometry</subject><subject>Milk, Human - chemistry</subject><subject>Other biological molecules</subject><subject>Pregnancy</subject><subject>Radioligand Assay</subject><subject>Reference Values</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAUhYMo4_j4BwrdKLqo5jZtmmwEGXzBoBsFdyFNbjXax5i0wsyvt-MM487VXZzvHC4fIUdAL4ACv6SU8jiR8Hom4VwCz2kstsgYqKRxAjTdJuMNskv2QvigFCDlckRGCU2yhPExgUfd9V5X1Txqjem9d81bVGCzaK3TC5y5BkPkmui9r3UT1a76PCA7pa4CHq7vPnm5vXme3MfTp7uHyfU0NkzkXZzbNM2ERJFTsKiZyBLOGJZQaslLi8wKgIKzhBuhjRQZs1kuCgm2hFyAYfvkdLU78-1Xj6FTtQsGq0o32PZBCZqlnCZyANMVaHwbgsdSzbyrtZ8roGppSi01qKUGJUH9mlJiqB2v9_uiRrsprdUM-ck618HoqvS6MS78bUvOIeMwcFcrDgcZ3w69CsZhY9A6j6ZTtnX_P_IDmmmD5A</recordid><startdate>19910329</startdate><enddate>19910329</enddate><creator>Peña, C.</creator><creator>Medina, J.H.</creator><creator>Piva, M.</creator><creator>Diaz, L.E.</creator><creator>Danilowicz, C.</creator><creator>Paladini, A.C.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19910329</creationdate><title>Naturally occurring benzodiazepines in human milk</title><author>Peña, C. ; Medina, J.H. ; Piva, M. ; Diaz, L.E. ; Danilowicz, C. ; Paladini, A.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-7d44589e8701dea3852633ef1fa96fde3d811b6326c8ac9853d578b91df1781c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Analytical, structural and metabolic biochemistry</topic><topic>Aromatic and heterocyclic compounds</topic><topic>Benzodiazepines - analysis</topic><topic>Benzodiazepines - blood</topic><topic>Biological and medical sciences</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heterocyclic compounds, pigments</topic><topic>Humans</topic><topic>Male</topic><topic>Mass Spectrometry</topic><topic>Milk, Human - chemistry</topic><topic>Other biological molecules</topic><topic>Pregnancy</topic><topic>Radioligand Assay</topic><topic>Reference Values</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peña, C.</creatorcontrib><creatorcontrib>Medina, J.H.</creatorcontrib><creatorcontrib>Piva, M.</creatorcontrib><creatorcontrib>Diaz, L.E.</creatorcontrib><creatorcontrib>Danilowicz, C.</creatorcontrib><creatorcontrib>Paladini, A.C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peña, C.</au><au>Medina, J.H.</au><au>Piva, M.</au><au>Diaz, L.E.</au><au>Danilowicz, C.</au><au>Paladini, A.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Naturally occurring benzodiazepines in human milk</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1991-03-29</date><risdate>1991</risdate><volume>175</volume><issue>3</issue><spage>1042</spage><epage>1050</epage><pages>1042-1050</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><coden>BBRCA9</coden><abstract>The presence of benzodiazepine-like molecules was detected radioimmunologically in the plasma and milk of 12 women and in the plasma of 9 men. All subjects were non-users of benzodiazepines.
The concentration of these biological materials expressed as diazepam equivalents per mL amounted to 2.54 ± 0.74 ng in male plasma; to 2.20 ± 0.35 ng in female plasma and to 1.91 ± 0.54 ng in milk. Further investigation of the active compounds in milk permitted the unequivocal identification of diazepam, both free and bound to a presumably protein carrier and, at least, three more benzodiazepine-like molecules. Their origin either from dietary sources or as a result of endogenous biosynthesis is still unclear.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>2025236</pmid><doi>10.1016/0006-291X(91)91670-8</doi><tpages>9</tpages></addata></record> |
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| ispartof | Biochemical and biophysical research communications, 1991-03, Vol.175 (3), p.1042-1050 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Analytical, structural and metabolic biochemistry Aromatic and heterocyclic compounds Benzodiazepines - analysis Benzodiazepines - blood Biological and medical sciences Chromatography, High Pressure Liquid Female Fundamental and applied biological sciences. Psychology Heterocyclic compounds, pigments Humans Male Mass Spectrometry Milk, Human - chemistry Other biological molecules Pregnancy Radioligand Assay Reference Values |
| title | Naturally occurring benzodiazepines in human milk |
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