Mammographic densities and risk of breast cancer
To determine the relation of mammographic densities to subsequent breast cancer risk, a case—control study was undertaken using prediagnostic mammograms of screening program participants. Mammograms of cases (n = 266) and controls (n = 301) were blindly assessed for mammographic densities, which wer...
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| Veröffentlicht in: | Cancer 1991-06, Vol.67 (11), p.2833-2838 |
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| container_issue | 11 |
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| container_title | Cancer |
| container_volume | 67 |
| creator | Saftlas, Audrey F. Hoover, Robert N. Brinton, Louise A. Szklo, Moyses Olson, David R. Salane, Martine Wolfe, John N. |
| description | To determine the relation of mammographic densities to subsequent breast cancer risk, a case—control study was undertaken using prediagnostic mammograms of screening program participants. Mammograms of cases (n = 266) and controls (n = 301) were blindly assessed for mammographic densities, which were measured by planimetry. The odds of breast cancer increased steadily with increasing breast density (test for trend, P < 0.0001). Breast cancer odds was 1.7 for densities between 5% and 24.9%, 2.5 for 25% through 44.9%, 3.8 for 45% through 64%, and 4.3 for densities of 65% and greater (referent = |
| doi_str_mv | 10.1002/1097-0142(19910601)67:11<2833::AID-CNCR2820671121>3.0.CO;2-U |
| format | Article |
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Mammograms of cases (n = 266) and controls (n = 301) were blindly assessed for mammographic densities, which were measured by planimetry. The odds of breast cancer increased steadily with increasing breast density (test for trend, P < 0.0001). Breast cancer odds was 1.7 for densities between 5% and 24.9%, 2.5 for 25% through 44.9%, 3.8 for 45% through 64%, and 4.3 for densities of 65% and greater (referent = <5% densities). Odds ratios also increased with increasing densities among women with the P2 and DY mammographic patterns. These findings suggest that the percentage of mammographic densities in the breast can predict breast cancer risk more accurately than a qualitative assessment of mammographic patterns.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(19910601)67:11<2833::AID-CNCR2820671121>3.0.CO;2-U</identifier><identifier>PMID: 2025849</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; Breast - pathology ; Breast Neoplasms - diagnostic imaging ; Case-Control Studies ; Female ; Humans ; Mammography ; Middle Aged ; Odds Ratio ; Prognosis ; Risk Factors ; Time Factors</subject><ispartof>Cancer, 1991-06, Vol.67 (11), p.2833-2838</ispartof><rights>Copyright © 1991 American Cancer Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c5381-596b04556f72a4e0e8d0887a4fd8070ab66d102c68d8b91fd19e0ed3ededae9d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2025849$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saftlas, Audrey F.</creatorcontrib><creatorcontrib>Hoover, Robert N.</creatorcontrib><creatorcontrib>Brinton, Louise A.</creatorcontrib><creatorcontrib>Szklo, Moyses</creatorcontrib><creatorcontrib>Olson, David R.</creatorcontrib><creatorcontrib>Salane, Martine</creatorcontrib><creatorcontrib>Wolfe, John N.</creatorcontrib><title>Mammographic densities and risk of breast cancer</title><title>Cancer</title><addtitle>Cancer</addtitle><description>To determine the relation of mammographic densities to subsequent breast cancer risk, a case—control study was undertaken using prediagnostic mammograms of screening program participants. Mammograms of cases (n = 266) and controls (n = 301) were blindly assessed for mammographic densities, which were measured by planimetry. The odds of breast cancer increased steadily with increasing breast density (test for trend, P < 0.0001). Breast cancer odds was 1.7 for densities between 5% and 24.9%, 2.5 for 25% through 44.9%, 3.8 for 45% through 64%, and 4.3 for densities of 65% and greater (referent = <5% densities). Odds ratios also increased with increasing densities among women with the P2 and DY mammographic patterns. These findings suggest that the percentage of mammographic densities in the breast can predict breast cancer risk more accurately than a qualitative assessment of mammographic patterns.</description><subject>Adult</subject><subject>Aged</subject><subject>Breast - pathology</subject><subject>Breast Neoplasms - diagnostic imaging</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Mammography</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Prognosis</subject><subject>Risk Factors</subject><subject>Time Factors</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkE9r20AQxZeSkDppP0JBp5Ie5Mzsale7TggY5S-kNZQaeggMK-0qVWJZ7q5NyLePjJ1Aegj0NAzvzXvDj7EzhCEC8CMEk6eAGT9EYxAU4DeVjxBPuBZiNBpfn6XFj-In1xxUjsjxVAxhWEyOeTr9wAav5ztsAAA6lZn4_ZHtx3jfrzmXYo_tceBSZ2bA4Ltt2-4u2MWfpkqcn8dm2fiY2LlLQhMfkq5OyuBtXCaVnVc-fGK7tZ1F_3k7D9j04vxXcZXeTC6vi_FNWkmhMZVGlZBJqeqc28yD1w60zm1WOw052FIph8ArpZ0uDdYOTW9ywjvvrDdOHLCvm9xF6P6ufFxS28TKz2Z27rtVJA0ykyYTvfF2Y6xCF2PwNS1C09rwRAi0BkprIrQmQi9ASeWESGugRD1QeguUBAEVE-I07eO_bP9Yla13r-Fbgr1-t9Efm5l_-s_ud6v_UcQz2ciSeQ</recordid><startdate>19910601</startdate><enddate>19910601</enddate><creator>Saftlas, Audrey F.</creator><creator>Hoover, Robert N.</creator><creator>Brinton, Louise A.</creator><creator>Szklo, Moyses</creator><creator>Olson, David R.</creator><creator>Salane, Martine</creator><creator>Wolfe, John N.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19910601</creationdate><title>Mammographic densities and risk of breast cancer</title><author>Saftlas, Audrey F. ; Hoover, Robert N. ; Brinton, Louise A. ; Szklo, Moyses ; Olson, David R. ; Salane, Martine ; Wolfe, John N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5381-596b04556f72a4e0e8d0887a4fd8070ab66d102c68d8b91fd19e0ed3ededae9d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Breast - pathology</topic><topic>Breast Neoplasms - diagnostic imaging</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Mammography</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>Prognosis</topic><topic>Risk Factors</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saftlas, Audrey F.</creatorcontrib><creatorcontrib>Hoover, Robert N.</creatorcontrib><creatorcontrib>Brinton, Louise A.</creatorcontrib><creatorcontrib>Szklo, Moyses</creatorcontrib><creatorcontrib>Olson, David R.</creatorcontrib><creatorcontrib>Salane, Martine</creatorcontrib><creatorcontrib>Wolfe, John N.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saftlas, Audrey F.</au><au>Hoover, Robert N.</au><au>Brinton, Louise A.</au><au>Szklo, Moyses</au><au>Olson, David R.</au><au>Salane, Martine</au><au>Wolfe, John N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mammographic densities and risk of breast cancer</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1991-06-01</date><risdate>1991</risdate><volume>67</volume><issue>11</issue><spage>2833</spage><epage>2838</epage><pages>2833-2838</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><abstract>To determine the relation of mammographic densities to subsequent breast cancer risk, a case—control study was undertaken using prediagnostic mammograms of screening program participants. Mammograms of cases (n = 266) and controls (n = 301) were blindly assessed for mammographic densities, which were measured by planimetry. The odds of breast cancer increased steadily with increasing breast density (test for trend, P < 0.0001). Breast cancer odds was 1.7 for densities between 5% and 24.9%, 2.5 for 25% through 44.9%, 3.8 for 45% through 64%, and 4.3 for densities of 65% and greater (referent = <5% densities). Odds ratios also increased with increasing densities among women with the P2 and DY mammographic patterns. These findings suggest that the percentage of mammographic densities in the breast can predict breast cancer risk more accurately than a qualitative assessment of mammographic patterns.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>2025849</pmid><doi>10.1002/1097-0142(19910601)67:11<2833::AID-CNCR2820671121>3.0.CO;2-U</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cancer, 1991-06, Vol.67 (11), p.2833-2838 |
| issn | 0008-543X 1097-0142 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Aged Breast - pathology Breast Neoplasms - diagnostic imaging Case-Control Studies Female Humans Mammography Middle Aged Odds Ratio Prognosis Risk Factors Time Factors |
| title | Mammographic densities and risk of breast cancer |
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