[20] Preparation of antibody-linked cytotoxic agents

This chapter presents the preparation of antibody-linked cytotoxic agents. It discusses the strategy of linking cytotoxic agents to immunoglobulins so that biologically active conjugates retaining agent and antibody activities are produced. Immunoglobulins share a number of distinctive structural fe...

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Veröffentlicht in:	Methods in Enzymology 1983, Vol.93, p.280-333
Hauptverfasser:	Ghose, Tarun I., Huntley Blair, A., Kulkarni, Padmaja N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - immunology Antibody-Dependent Cell Cytotoxicity Antigen-Antibody Complex Antineoplastic Agents - administration & dosage Humans Immunoglobulin Fab Fragments - immunology Immunoglobulins - immunology Immunologic Techniques Indicators and Reagents Mice - immunology Neoplasms - immunology Rabbits - immunology
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