Recurrence of Hyperprolactinemia after Selective Transsphenoidal Adenomectomy in Women with Prolactinoma
To assess the long-term prognosis for women with prolactinoma after selective transsphenoidal adenomectomy, we followed 44 patients for 6.2±1.5 years. Group 1 (28 patients) had microprolactinomas, and Group 2 (16 patients) had macroprolactinomas. After surgery, normal plasma prolactin levels, resump...
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| Veröffentlicht in: | The New England journal of medicine 1983-08, Vol.309 (5), p.280-283 |
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| description | To assess the long-term prognosis for women with prolactinoma after selective transsphenoidal adenomectomy, we followed 44 patients for 6.2±1.5 years. Group 1 (28 patients) had microprolactinomas, and Group 2 (16 patients) had macroprolactinomas. After surgery, normal plasma prolactin levels, resumption of menses, and cessation of galactorrhea were observed in 24 Group 1 patients (85 per cent) and 5 Group 2 patients (31 per cent). Hyperprolactinemia recurred in 12 of the 24 Group 1 patients and in 4 of the 5 Group 2 patients after 4±1.3 and 2.5±1.6 years of remission, respectively. There was no radiologic evidence of tumor recurrence in any patient, and no relation was found between the occurrence of pregnancy after surgery and the recurrence of hyperprolactinemia. Clinical and biologic features before surgery could not predict the long-term outcome. However, the immediate postoperative level of plasma prolactin was significantly lower in patients in whom normal prolactinemia (6.4±1.1 ng per milliliter) was maintained than in those who relapsed (11.7±1.5 ng per milliliter) (P |
| doi_str_mv | 10.1056/NEJM198308043090505 |
| format | Article |
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THE availability of the microsurgical technique for exploration of the sella turcica by the transsphenoidal route
1
2
3
has allowed great progress in the management of the amenorrhea–galactorrhea syndrome. We
4
,
5
and others
6
7
8
9
have reported high cure rates in the treatment of prolactinomas by transsphenoidal selective adenomectomy. However, long-term follow-up data are not available, and the tendency of prolactinomas to recur is not known. We have studied 44 women with prolactinoma who underwent a transsphenoidal removal of their adenoma and in whom clinical and laboratory data were assessed 5 to 10 years after surgery.
Methods
From 1970 to 1976, 105 women with amenorrhea–galactorrhea . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM198308043090505</identifier><identifier>PMID: 6866052</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Adenoma ; Adenoma - blood ; Adenoma - surgery ; Adult ; Amenorrhea ; Discriminant analysis ; Endocrinology ; Female ; Follow-Up Studies ; Humans ; Hyperprolactinemia ; Patients ; Pituitary ; Pituitary gland ; Pituitary Neoplasms - blood ; Pituitary Neoplasms - surgery ; Plasma ; Pregnancy ; Prolactin ; Prolactin - blood ; Prolactin - secretion ; Recurrence ; Remission ; Risk ; Surgery ; Tumors</subject><ispartof>The New England journal of medicine, 1983-08, Vol.309 (5), p.280-283</ispartof><rights>Copyright Massachusetts Medical Society Aug 4, 1983</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-b1baa809a61822feebed603480a4538bbb591310c7bcb1702dd204c45cb3aa173</citedby><cites>FETCH-LOGICAL-c316t-b1baa809a61822feebed603480a4538bbb591310c7bcb1702dd204c45cb3aa173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1875435756?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,64364,64366,64368,72218</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6866052$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Serri, Omar</creatorcontrib><creatorcontrib>Rasio, Eugenio</creatorcontrib><creatorcontrib>Beauregard, Hugues</creatorcontrib><creatorcontrib>Hardy, Jules</creatorcontrib><creatorcontrib>Somma, Maurice</creatorcontrib><title>Recurrence of Hyperprolactinemia after Selective Transsphenoidal Adenomectomy in Women with Prolactinoma</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>To assess the long-term prognosis for women with prolactinoma after selective transsphenoidal adenomectomy, we followed 44 patients for 6.2±1.5 years. Group 1 (28 patients) had microprolactinomas, and Group 2 (16 patients) had macroprolactinomas. After surgery, normal plasma prolactin levels, resumption of menses, and cessation of galactorrhea were observed in 24 Group 1 patients (85 per cent) and 5 Group 2 patients (31 per cent). Hyperprolactinemia recurred in 12 of the 24 Group 1 patients and in 4 of the 5 Group 2 patients after 4±1.3 and 2.5±1.6 years of remission, respectively. There was no radiologic evidence of tumor recurrence in any patient, and no relation was found between the occurrence of pregnancy after surgery and the recurrence of hyperprolactinemia. Clinical and biologic features before surgery could not predict the long-term outcome. However, the immediate postoperative level of plasma prolactin was significantly lower in patients in whom normal prolactinemia (6.4±1.1 ng per milliliter) was maintained than in those who relapsed (11.7±1.5 ng per milliliter) (P<0.02). We conclude that recurrence of hyperprolactinemia after successful surgery is frequent but delayed. The immediate postoperative level of plasma prolactin may be a predictive risk factor. (N Engl J Med 1983; 309:280–3.)
THE availability of the microsurgical technique for exploration of the sella turcica by the transsphenoidal route
1
2
3
has allowed great progress in the management of the amenorrhea–galactorrhea syndrome. We
4
,
5
and others
6
7
8
9
have reported high cure rates in the treatment of prolactinomas by transsphenoidal selective adenomectomy. However, long-term follow-up data are not available, and the tendency of prolactinomas to recur is not known. We have studied 44 women with prolactinoma who underwent a transsphenoidal removal of their adenoma and in whom clinical and laboratory data were assessed 5 to 10 years after surgery.
Methods
From 1970 to 1976, 105 women with amenorrhea–galactorrhea . . .</description><subject>Adenoma</subject><subject>Adenoma - blood</subject><subject>Adenoma - surgery</subject><subject>Adult</subject><subject>Amenorrhea</subject><subject>Discriminant analysis</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Hyperprolactinemia</subject><subject>Patients</subject><subject>Pituitary</subject><subject>Pituitary gland</subject><subject>Pituitary Neoplasms - blood</subject><subject>Pituitary Neoplasms - surgery</subject><subject>Plasma</subject><subject>Pregnancy</subject><subject>Prolactin</subject><subject>Prolactin - blood</subject><subject>Prolactin - secretion</subject><subject>Recurrence</subject><subject>Remission</subject><subject>Risk</subject><subject>Surgery</subject><subject>Tumors</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kU1r3DAQhkVJ2W7S_IJQEBRyCW5H1oflYwhpk7D9oE3I0UjymPViyRvJbtl_X5Xd9lBK5qIZvc-8SDOEnDF4x0Cq95-v7z6xWnPQIDjUIEG-IEsmOS-EAHVElgClLkRV81fkOKUN5GCiXpCF0kqBLJdk_Q3dHCMGh3Ts6M1ui3Ebx8G4qQ_oe0NNN2Gk33HAfPUD6X00IaXtGsPYt2agl23OfBZHv6N9oI-5CPRnP63p1z9GozevycvODAlPD-cJefhwfX91U6y-fLy9ulwVjjM1FZZZYzTURjFdlh2ixVYBFxqMkFxba2XNOANXWWdZBWXbliCckM5yY1jFT8j53jf_4mnGNDW-Tw6HwQQc59RokHlYjGfw7T_gZpxjyG9rmK4yJCupMsX3lItjShG7Zht7b-KuYdD83kLzny3krjcH79l6bP_2HMae9Yu97n1qAm78s26_ABm2j68</recordid><startdate>19830804</startdate><enddate>19830804</enddate><creator>Serri, Omar</creator><creator>Rasio, Eugenio</creator><creator>Beauregard, Hugues</creator><creator>Hardy, Jules</creator><creator>Somma, Maurice</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>19830804</creationdate><title>Recurrence of Hyperprolactinemia after Selective Transsphenoidal Adenomectomy in Women with Prolactinoma</title><author>Serri, Omar ; Rasio, Eugenio ; Beauregard, Hugues ; Hardy, Jules ; Somma, Maurice</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-b1baa809a61822feebed603480a4538bbb591310c7bcb1702dd204c45cb3aa173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Adenoma</topic><topic>Adenoma - blood</topic><topic>Adenoma - surgery</topic><topic>Adult</topic><topic>Amenorrhea</topic><topic>Discriminant analysis</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Hyperprolactinemia</topic><topic>Patients</topic><topic>Pituitary</topic><topic>Pituitary gland</topic><topic>Pituitary Neoplasms - blood</topic><topic>Pituitary Neoplasms - surgery</topic><topic>Plasma</topic><topic>Pregnancy</topic><topic>Prolactin</topic><topic>Prolactin - blood</topic><topic>Prolactin - secretion</topic><topic>Recurrence</topic><topic>Remission</topic><topic>Risk</topic><topic>Surgery</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Serri, Omar</creatorcontrib><creatorcontrib>Rasio, Eugenio</creatorcontrib><creatorcontrib>Beauregard, Hugues</creatorcontrib><creatorcontrib>Hardy, Jules</creatorcontrib><creatorcontrib>Somma, Maurice</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Serri, Omar</au><au>Rasio, Eugenio</au><au>Beauregard, Hugues</au><au>Hardy, Jules</au><au>Somma, Maurice</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recurrence of Hyperprolactinemia after Selective Transsphenoidal Adenomectomy in Women with Prolactinoma</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1983-08-04</date><risdate>1983</risdate><volume>309</volume><issue>5</issue><spage>280</spage><epage>283</epage><pages>280-283</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><abstract>To assess the long-term prognosis for women with prolactinoma after selective transsphenoidal adenomectomy, we followed 44 patients for 6.2±1.5 years. Group 1 (28 patients) had microprolactinomas, and Group 2 (16 patients) had macroprolactinomas. After surgery, normal plasma prolactin levels, resumption of menses, and cessation of galactorrhea were observed in 24 Group 1 patients (85 per cent) and 5 Group 2 patients (31 per cent). Hyperprolactinemia recurred in 12 of the 24 Group 1 patients and in 4 of the 5 Group 2 patients after 4±1.3 and 2.5±1.6 years of remission, respectively. There was no radiologic evidence of tumor recurrence in any patient, and no relation was found between the occurrence of pregnancy after surgery and the recurrence of hyperprolactinemia. Clinical and biologic features before surgery could not predict the long-term outcome. However, the immediate postoperative level of plasma prolactin was significantly lower in patients in whom normal prolactinemia (6.4±1.1 ng per milliliter) was maintained than in those who relapsed (11.7±1.5 ng per milliliter) (P<0.02). We conclude that recurrence of hyperprolactinemia after successful surgery is frequent but delayed. The immediate postoperative level of plasma prolactin may be a predictive risk factor. (N Engl J Med 1983; 309:280–3.)
THE availability of the microsurgical technique for exploration of the sella turcica by the transsphenoidal route
1
2
3
has allowed great progress in the management of the amenorrhea–galactorrhea syndrome. We
4
,
5
and others
6
7
8
9
have reported high cure rates in the treatment of prolactinomas by transsphenoidal selective adenomectomy. However, long-term follow-up data are not available, and the tendency of prolactinomas to recur is not known. We have studied 44 women with prolactinoma who underwent a transsphenoidal removal of their adenoma and in whom clinical and laboratory data were assessed 5 to 10 years after surgery.
Methods
From 1970 to 1976, 105 women with amenorrhea–galactorrhea . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>6866052</pmid><doi>10.1056/NEJM198308043090505</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
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| subjects | Adenoma Adenoma - blood Adenoma - surgery Adult Amenorrhea Discriminant analysis Endocrinology Female Follow-Up Studies Humans Hyperprolactinemia Patients Pituitary Pituitary gland Pituitary Neoplasms - blood Pituitary Neoplasms - surgery Plasma Pregnancy Prolactin Prolactin - blood Prolactin - secretion Recurrence Remission Risk Surgery Tumors |
| title | Recurrence of Hyperprolactinemia after Selective Transsphenoidal Adenomectomy in Women with Prolactinoma |
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