N-acetyl-β-endorphin1-31 antagonizes the suppressive effect of β-endorphin1-31 on murine splenocyte proliferation via a naloxone-resistant receptor

High affinity binding sites for beta-endorphin1-31 (beta-EP) have been observed on transformed mononuclear cells such as the human U937 monocyte-like cell line and the murine EL4-thymoma line, and on normal murine splenocytes. Binding of beta-EP at these sites is resistant to competition by naloxone...

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Veröffentlicht in:	Biochemical and biophysical research communications 1991-03, Vol.175 (3), p.936-942
Hauptverfasser:	SHAHABI, N. A, BURTNESS, M. Z, SHARP, B. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoacids, peptides. Hormones. Neuropeptides Analytical, structural and metabolic biochemistry Animals beta-Endorphin - analogs & derivatives beta-Endorphin - antagonists & inhibitors beta-Endorphin - pharmacology Biological and medical sciences Cells, Cultured DNA Replication - drug effects Female Fundamental and applied biological sciences. Psychology Kinetics Lymphocyte Activation - drug effects Lymphocytes - drug effects Lymphocytes - immunology Mice Mice, Inbred Strains Naloxone - pharmacology Peptide Fragments - antagonists & inhibitors Peptide Fragments - pharmacology Phytohemagglutinins Proteins Receptors, Opioid - drug effects Receptors, Opioid - physiology Spleen Thymidine - metabolism
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