Increased GDP binding and thermogenic activity in brown adipose tissue mitochondria during arousal of the hibernating garden dormouse ( Eliomys quercinus L.)
1. 1. The thermogenic activity of brown adipose tissue in hibernating garden dormice during hypothermie torpor and at different states of arousal were studied. High levels of GDP binding were observed on isolated brown fat mitochondria, indicating that the thermogenic proton conductance pathway is v...
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| Veröffentlicht in: | Comparative biochemistry and physiology. A, Comparative physiology Comparative physiology, 1991, Vol.98 (2), p.311-316 |
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| container_title | Comparative biochemistry and physiology. A, Comparative physiology |
| container_volume | 98 |
| creator | Martins, Regina Atgie, Claude Gineste, Laurent Nibbelink, Maryse Ambid, Louis Ricquier, Daniel |
| description | 1.
1. The thermogenic activity of brown adipose tissue in hibernating garden dormice during hypothermie torpor and at different states of arousal were studied. High levels of GDP binding were observed on isolated brown fat mitochondria, indicating that the thermogenic proton conductance pathway is very active in brown fat during arousal.
2.
2. In order to investigate this phenomenon, the uncoupling protein was assessed by immunological assay and the mRNA for UCP was analysed.
3.
3. Animals during arousal exibited neither increase in UCPmRNA nor an increase in UCP.
4.
4. Our results suggest that during the rewarming of garden dormice there is an acute unmasking of GDP binding sites on the protein. |
| doi_str_mv | 10.1016/0300-9629(91)90538-N |
| format | Article |
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1. The thermogenic activity of brown adipose tissue in hibernating garden dormice during hypothermie torpor and at different states of arousal were studied. High levels of GDP binding were observed on isolated brown fat mitochondria, indicating that the thermogenic proton conductance pathway is very active in brown fat during arousal.
2.
2. In order to investigate this phenomenon, the uncoupling protein was assessed by immunological assay and the mRNA for UCP was analysed.
3.
3. Animals during arousal exibited neither increase in UCPmRNA nor an increase in UCP.
4.
4. Our results suggest that during the rewarming of garden dormice there is an acute unmasking of GDP binding sites on the protein.</description><identifier>ISSN: 0300-9629</identifier><identifier>DOI: 10.1016/0300-9629(91)90538-N</identifier><identifier>PMID: 1673895</identifier><identifier>CODEN: CBPAB5</identifier><language>eng</language><publisher>New York, NY: Elsevier B.V</publisher><subject>Adipose Tissue, Brown - physiology ; Animals ; Arousal - physiology ; Biological and medical sciences ; Blotting, Northern ; Body Temperature Regulation - physiology ; Body Weight - physiology ; Fundamental and applied biological sciences. Psychology ; Guanosine Diphosphate - metabolism ; Hibernation - physiology ; Immunoblotting ; Mitochondria - physiology ; Protein Binding ; Rodentia - physiology ; Space life sciences ; Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Comparative biochemistry and physiology. A, Comparative physiology, 1991, Vol.98 (2), p.311-316</ispartof><rights>1991</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-a469ad6fdf56972f0048295431a967878a4c760c5adf9da671f8200d4d3421393</citedby><cites>FETCH-LOGICAL-c387t-a469ad6fdf56972f0048295431a967878a4c760c5adf9da671f8200d4d3421393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19564428$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1673895$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Martins, Regina</creatorcontrib><creatorcontrib>Atgie, Claude</creatorcontrib><creatorcontrib>Gineste, Laurent</creatorcontrib><creatorcontrib>Nibbelink, Maryse</creatorcontrib><creatorcontrib>Ambid, Louis</creatorcontrib><creatorcontrib>Ricquier, Daniel</creatorcontrib><title>Increased GDP binding and thermogenic activity in brown adipose tissue mitochondria during arousal of the hibernating garden dormouse ( Eliomys quercinus L.)</title><title>Comparative biochemistry and physiology. A, Comparative physiology</title><addtitle>Comp Biochem Physiol A Comp Physiol</addtitle><description>1.
1. The thermogenic activity of brown adipose tissue in hibernating garden dormice during hypothermie torpor and at different states of arousal were studied. High levels of GDP binding were observed on isolated brown fat mitochondria, indicating that the thermogenic proton conductance pathway is very active in brown fat during arousal.
2.
2. In order to investigate this phenomenon, the uncoupling protein was assessed by immunological assay and the mRNA for UCP was analysed.
3.
3. Animals during arousal exibited neither increase in UCPmRNA nor an increase in UCP.
4.
4. Our results suggest that during the rewarming of garden dormice there is an acute unmasking of GDP binding sites on the protein.</description><subject>Adipose Tissue, Brown - physiology</subject><subject>Animals</subject><subject>Arousal - physiology</subject><subject>Biological and medical sciences</subject><subject>Blotting, Northern</subject><subject>Body Temperature Regulation - physiology</subject><subject>Body Weight - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Guanosine Diphosphate - metabolism</subject><subject>Hibernation - physiology</subject><subject>Immunoblotting</subject><subject>Mitochondria - physiology</subject><subject>Protein Binding</subject><subject>Rodentia - physiology</subject><subject>Space life sciences</subject><subject>Thermoregulation. Hibernation. Estivation. 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Psychology</topic><topic>Guanosine Diphosphate - metabolism</topic><topic>Hibernation - physiology</topic><topic>Immunoblotting</topic><topic>Mitochondria - physiology</topic><topic>Protein Binding</topic><topic>Rodentia - physiology</topic><topic>Space life sciences</topic><topic>Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martins, Regina</creatorcontrib><creatorcontrib>Atgie, Claude</creatorcontrib><creatorcontrib>Gineste, Laurent</creatorcontrib><creatorcontrib>Nibbelink, Maryse</creatorcontrib><creatorcontrib>Ambid, Louis</creatorcontrib><creatorcontrib>Ricquier, Daniel</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Comparative biochemistry and physiology. A, Comparative physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martins, Regina</au><au>Atgie, Claude</au><au>Gineste, Laurent</au><au>Nibbelink, Maryse</au><au>Ambid, Louis</au><au>Ricquier, Daniel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased GDP binding and thermogenic activity in brown adipose tissue mitochondria during arousal of the hibernating garden dormouse ( Eliomys quercinus L.)</atitle><jtitle>Comparative biochemistry and physiology. A, Comparative physiology</jtitle><addtitle>Comp Biochem Physiol A Comp Physiol</addtitle><date>1991</date><risdate>1991</risdate><volume>98</volume><issue>2</issue><spage>311</spage><epage>316</epage><pages>311-316</pages><issn>0300-9629</issn><coden>CBPAB5</coden><abstract>1.
1. The thermogenic activity of brown adipose tissue in hibernating garden dormice during hypothermie torpor and at different states of arousal were studied. High levels of GDP binding were observed on isolated brown fat mitochondria, indicating that the thermogenic proton conductance pathway is very active in brown fat during arousal.
2.
2. In order to investigate this phenomenon, the uncoupling protein was assessed by immunological assay and the mRNA for UCP was analysed.
3.
3. Animals during arousal exibited neither increase in UCPmRNA nor an increase in UCP.
4.
4. Our results suggest that during the rewarming of garden dormice there is an acute unmasking of GDP binding sites on the protein.</abstract><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>1673895</pmid><doi>10.1016/0300-9629(91)90538-N</doi><tpages>6</tpages></addata></record> |
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| ispartof | Comparative biochemistry and physiology. A, Comparative physiology, 1991, Vol.98 (2), p.311-316 |
| issn | 0300-9629 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adipose Tissue, Brown - physiology Animals Arousal - physiology Biological and medical sciences Blotting, Northern Body Temperature Regulation - physiology Body Weight - physiology Fundamental and applied biological sciences. Psychology Guanosine Diphosphate - metabolism Hibernation - physiology Immunoblotting Mitochondria - physiology Protein Binding Rodentia - physiology Space life sciences Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Increased GDP binding and thermogenic activity in brown adipose tissue mitochondria during arousal of the hibernating garden dormouse ( Eliomys quercinus L.) |
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