Endotoxaemia in septic shock: clinical and post mortem correlations
The Limulus amoebocyte lysate assay was used as one of a series of laboratory and clinical investigations on a group of 31 patients suffering from septic shock in order to assess the clinical significance of this assay for the detection of circulating endotoxin in clinical gram-negative sepsis. Four...
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| Veröffentlicht in: | Intensive care medicine 1983, Vol.9 (3), p.117-122 |
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| container_title | Intensive care medicine |
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| creator | McCartney, A C Banks, J G Clements, G B Sleigh, J D Tehrani, M Ledingham, I M |
| description | The Limulus amoebocyte lysate assay was used as one of a series of laboratory and clinical investigations on a group of 31 patients suffering from septic shock in order to assess the clinical significance of this assay for the detection of circulating endotoxin in clinical gram-negative sepsis. Four patients with cardiogenic shock served as controls. Endotoxin was detected in the bloodstream of all patients with septic shock during the 24 h following referral and was not detected in the control patients. Eventual clinical recovery was associated with the disappearance of endotoxin from the peripheral blood. Blood cultures were unhelpful as a prognostic indicator in these critically ill patients. A quantitative assay of endotoxin in blood may allow a more precise relationship with the clinical manifestations of major sepsis. |
| doi_str_mv | 10.1007/BF01772577 |
| format | Article |
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Four patients with cardiogenic shock served as controls. Endotoxin was detected in the bloodstream of all patients with septic shock during the 24 h following referral and was not detected in the control patients. Eventual clinical recovery was associated with the disappearance of endotoxin from the peripheral blood. Blood cultures were unhelpful as a prognostic indicator in these critically ill patients. A quantitative assay of endotoxin in blood may allow a more precise relationship with the clinical manifestations of major sepsis.</description><identifier>ISSN: 0342-4642</identifier><identifier>EISSN: 1432-1238</identifier><identifier>DOI: 10.1007/BF01772577</identifier><identifier>PMID: 6863720</identifier><language>eng</language><publisher>United States</publisher><subject>Adolescent ; Adult ; Aged ; Endotoxins - blood ; Female ; Humans ; Kidney - pathology ; Limulus Test ; Lung - pathology ; Male ; Middle Aged ; Prognosis ; Prospective Studies ; Shock, Septic - blood ; Shock, Septic - pathology</subject><ispartof>Intensive care medicine, 1983, Vol.9 (3), p.117-122</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c197t-d7a0a3db2f695975932f72f28fb8d7b76ad4c88d102255f0b62e2a1599f5973e3</citedby><cites>FETCH-LOGICAL-c197t-d7a0a3db2f695975932f72f28fb8d7b76ad4c88d102255f0b62e2a1599f5973e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6863720$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McCartney, A C</creatorcontrib><creatorcontrib>Banks, J G</creatorcontrib><creatorcontrib>Clements, G B</creatorcontrib><creatorcontrib>Sleigh, J D</creatorcontrib><creatorcontrib>Tehrani, M</creatorcontrib><creatorcontrib>Ledingham, I M</creatorcontrib><title>Endotoxaemia in septic shock: clinical and post mortem correlations</title><title>Intensive care medicine</title><addtitle>Intensive Care Med</addtitle><description>The Limulus amoebocyte lysate assay was used as one of a series of laboratory and clinical investigations on a group of 31 patients suffering from septic shock in order to assess the clinical significance of this assay for the detection of circulating endotoxin in clinical gram-negative sepsis. Four patients with cardiogenic shock served as controls. Endotoxin was detected in the bloodstream of all patients with septic shock during the 24 h following referral and was not detected in the control patients. Eventual clinical recovery was associated with the disappearance of endotoxin from the peripheral blood. Blood cultures were unhelpful as a prognostic indicator in these critically ill patients. A quantitative assay of endotoxin in blood may allow a more precise relationship with the clinical manifestations of major sepsis.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Endotoxins - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Kidney - pathology</subject><subject>Limulus Test</subject><subject>Lung - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Shock, Septic - blood</subject><subject>Shock, Septic - pathology</subject><issn>0342-4642</issn><issn>1432-1238</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0EtLAzEUhuEgSq3VjXshKxfCaC6TmzstrQoFN7oeMrlgdGYyJinov3ekRVdn8_DBeQE4x-gaIyRu7tcIC0GYEAdgjmtKKkyoPARzRGtS1bwmx-Ak53c0Mc7wDMy45FQQNAfL1WBjiV_a9UHDMMDsxhIMzG_RfNxC04UhGN1BPVg4xlxgH1NxPTQxJdfpEuKQT8GR1112Z_u7AK_r1cvysdo8Pzwt7zaVwUqUygqNNLUt8VwxJZiixAviifSttKIVXNvaSGkxIoQxj1pOHNGYKeUnTh1dgMvd7pji59bl0vQhG9d1enBxmxuJ2PQvVxO82kGTYs7J-WZModfpu8Go-S3W_Beb8MV-ddv2zv7RfSL6A2dqZQk</recordid><startdate>1983</startdate><enddate>1983</enddate><creator>McCartney, A C</creator><creator>Banks, J G</creator><creator>Clements, G B</creator><creator>Sleigh, J D</creator><creator>Tehrani, M</creator><creator>Ledingham, I M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1983</creationdate><title>Endotoxaemia in septic shock: clinical and post mortem correlations</title><author>McCartney, A C ; Banks, J G ; Clements, G B ; Sleigh, J D ; Tehrani, M ; Ledingham, I M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c197t-d7a0a3db2f695975932f72f28fb8d7b76ad4c88d102255f0b62e2a1599f5973e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Endotoxins - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Kidney - pathology</topic><topic>Limulus Test</topic><topic>Lung - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Shock, Septic - blood</topic><topic>Shock, Septic - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McCartney, A C</creatorcontrib><creatorcontrib>Banks, J G</creatorcontrib><creatorcontrib>Clements, G B</creatorcontrib><creatorcontrib>Sleigh, J D</creatorcontrib><creatorcontrib>Tehrani, M</creatorcontrib><creatorcontrib>Ledingham, I M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Intensive care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McCartney, A C</au><au>Banks, J G</au><au>Clements, G B</au><au>Sleigh, J D</au><au>Tehrani, M</au><au>Ledingham, I M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endotoxaemia in septic shock: clinical and post mortem correlations</atitle><jtitle>Intensive care medicine</jtitle><addtitle>Intensive Care Med</addtitle><date>1983</date><risdate>1983</risdate><volume>9</volume><issue>3</issue><spage>117</spage><epage>122</epage><pages>117-122</pages><issn>0342-4642</issn><eissn>1432-1238</eissn><abstract>The Limulus amoebocyte lysate assay was used as one of a series of laboratory and clinical investigations on a group of 31 patients suffering from septic shock in order to assess the clinical significance of this assay for the detection of circulating endotoxin in clinical gram-negative sepsis. 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| fulltext | fulltext |
| identifier | ISSN: 0342-4642 |
| ispartof | Intensive care medicine, 1983, Vol.9 (3), p.117-122 |
| issn | 0342-4642 1432-1238 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80534269 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Adolescent Adult Aged Endotoxins - blood Female Humans Kidney - pathology Limulus Test Lung - pathology Male Middle Aged Prognosis Prospective Studies Shock, Septic - blood Shock, Septic - pathology |
| title | Endotoxaemia in septic shock: clinical and post mortem correlations |
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