Synthetic peptides mimic subtype specificity of foot-and-mouth disease virus
The major immunogen of foot-and-mouth disease virus (FMDV) is located between amino acids 141–160 of the capsid protein VP1. Synthetic peptides corresponding to the major immunogenic region give good neutralising antibody responses and protection in guinea pigs. To define more precisely the immunoge...
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| Veröffentlicht in: | FEBS letters 1983-07, Vol.157 (2), p.261-264 |
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| container_title | FEBS letters |
| container_volume | 157 |
| creator | Clarke, B.E. Carroll, A.R. Rowlands, D.J. Nicholson, B.H. Houghten, R.A. Lerner, R.A. Brown, F. |
| description | The major immunogen of foot-and-mouth disease virus (FMDV) is located between amino acids 141–160 of the capsid protein VP1. Synthetic peptides corresponding to the major immunogenic region give good neutralising antibody responses and protection in guinea pigs. To define more precisely the immunogenic site of the virus, we have examined serological differences between subtypes of the A serotype using synthetic peptides covering the 141–160 region. We show that these synthetic peptides carry determinants which mimic the subtype specificity of the virus. The correlation between these results and predictive structural models, based on the amino acid sequence, is discussed. |
| doi_str_mv | 10.1016/0014-5793(83)80558-4 |
| format | Article |
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Synthetic peptides corresponding to the major immunogenic region give good neutralising antibody responses and protection in guinea pigs. To define more precisely the immunogenic site of the virus, we have examined serological differences between subtypes of the A serotype using synthetic peptides covering the 141–160 region. We show that these synthetic peptides carry determinants which mimic the subtype specificity of the virus. 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Synthetic peptides corresponding to the major immunogenic region give good neutralising antibody responses and protection in guinea pigs. To define more precisely the immunogenic site of the virus, we have examined serological differences between subtypes of the A serotype using synthetic peptides covering the 141–160 region. We show that these synthetic peptides carry determinants which mimic the subtype specificity of the virus. The correlation between these results and predictive structural models, based on the amino acid sequence, is discussed.</description><subject>Amino Acid Sequence</subject><subject>Antigenic variation</subject><subject>Aphthovirus - immunology</subject><subject>Epitopes - analysis</subject><subject>Foot-and-mouth disease virus</subject><subject>Models, Molecular</subject><subject>Peptides - chemical synthesis</subject><subject>Picornavirus</subject><subject>Structural model</subject><subject>Synthetic peptide</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1LxDAQhoMoun78A4WeRA_VpPloehF02VVhwYN7D9lkipHttjbpSv-96XbxKJ6Gmfedd4YHoUuC7wgm4h5jwlKeF_RG0luJOZcpO0ATInOaUibkIZr8Wk7QqfefOPaSFMfoWJACi1xM0OK934QPCM4kDTTBWfBJ5arY-m4V-gYS34BxpTMu9EldJmVdh1RvbFrVXfhIrPOgPSRb13b-HB2Veu3hYl_P0HI-W05f0sXb8-v0cZEaJgRLVyWRJstkHl_gTOsys6LkOaeWM0KJ1UXBKcFAs2jMeLTCihc807nU2kp6hq7H2KatvzrwQVXOG1iv9QbqzqvIIhMcs2hko9G0tfctlKppXaXbXhGsBoZqAKQGQEpStWOohrWrfX63qsD-Lu2hRX0-6t9uDf2_MtV89pQNwjCXdDcdDj2MQRBhbR20yhsHGwPWtWCCsrX7-9MfPBGTeg</recordid><startdate>19830704</startdate><enddate>19830704</enddate><creator>Clarke, B.E.</creator><creator>Carroll, A.R.</creator><creator>Rowlands, D.J.</creator><creator>Nicholson, B.H.</creator><creator>Houghten, R.A.</creator><creator>Lerner, R.A.</creator><creator>Brown, F.</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19830704</creationdate><title>Synthetic peptides mimic subtype specificity of foot-and-mouth disease virus</title><author>Clarke, B.E. ; Carroll, A.R. ; Rowlands, D.J. ; Nicholson, B.H. ; Houghten, R.A. ; Lerner, R.A. ; Brown, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4664-bf18c228706754aaf2d6f5753d54131da995310e32f1825c22eb5952a78aad83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Amino Acid Sequence</topic><topic>Antigenic variation</topic><topic>Aphthovirus - immunology</topic><topic>Epitopes - analysis</topic><topic>Foot-and-mouth disease virus</topic><topic>Models, Molecular</topic><topic>Peptides - chemical synthesis</topic><topic>Picornavirus</topic><topic>Structural model</topic><topic>Synthetic peptide</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Clarke, B.E.</creatorcontrib><creatorcontrib>Carroll, A.R.</creatorcontrib><creatorcontrib>Rowlands, D.J.</creatorcontrib><creatorcontrib>Nicholson, B.H.</creatorcontrib><creatorcontrib>Houghten, R.A.</creatorcontrib><creatorcontrib>Lerner, R.A.</creatorcontrib><creatorcontrib>Brown, F.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Clarke, B.E.</au><au>Carroll, A.R.</au><au>Rowlands, D.J.</au><au>Nicholson, B.H.</au><au>Houghten, R.A.</au><au>Lerner, R.A.</au><au>Brown, F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthetic peptides mimic subtype specificity of foot-and-mouth disease virus</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1983-07-04</date><risdate>1983</risdate><volume>157</volume><issue>2</issue><spage>261</spage><epage>264</epage><pages>261-264</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>The major immunogen of foot-and-mouth disease virus (FMDV) is located between amino acids 141–160 of the capsid protein VP1. Synthetic peptides corresponding to the major immunogenic region give good neutralising antibody responses and protection in guinea pigs. To define more precisely the immunogenic site of the virus, we have examined serological differences between subtypes of the A serotype using synthetic peptides covering the 141–160 region. We show that these synthetic peptides carry determinants which mimic the subtype specificity of the virus. The correlation between these results and predictive structural models, based on the amino acid sequence, is discussed.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>6190676</pmid><doi>10.1016/0014-5793(83)80558-4</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0014-5793 |
| ispartof | FEBS letters, 1983-07, Vol.157 (2), p.261-264 |
| issn | 0014-5793 1873-3468 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Amino Acid Sequence Antigenic variation Aphthovirus - immunology Epitopes - analysis Foot-and-mouth disease virus Models, Molecular Peptides - chemical synthesis Picornavirus Structural model Synthetic peptide |
| title | Synthetic peptides mimic subtype specificity of foot-and-mouth disease virus |
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