Serum folic acid levels and antipyrine clearance rates in smokers and non-smokers
Serum folic acid (FA) levels and antipyrine clearance rates were determined in 15 healthy male subjects who had not been administered any drug and alcohol for a month preceding the study. Eight of the 15 subjects smoked cigarettes daily while the remaining seven did not. The serum FA levels were mea...
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| Veröffentlicht in: | Drug and Alcohol Dependence 1983-04, Vol.11 (2), p.201-207 |
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| container_title | Drug and Alcohol Dependence |
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| creator | Nakazawa, Yoichi Chiba, Kan Imatoh, Nobuhiko Kotorii, Tatayu Sakamoto, Tetsuro Ishizaki, Takashi |
| description | Serum folic acid (FA) levels and antipyrine clearance rates were determined in 15 healthy male subjects who had not been administered any drug and alcohol for a month preceding the study. Eight of the 15 subjects smoked cigarettes daily while the remaining seven did not. The serum FA levels were measured by
Lactobacillus casei bioassay. The antipyrine clearance rates were estimated in plasma or saliva obtained after oral administration of antipyrine for evaluating the activity of hepatic microsomal oxidase. The serum FA levels in the smokers were significantly lower than those in the non-smokers and the antipyrine clearance rates were significantly higher in the smokers compared with the non-smokers. The increase of the antipyrine clearance rates in the smokers was supposed to be caused by an increase in the activity of hepatic microsomal oxidase since it has been established that polycyclic aromatic hydrocarbons contained in cigarette smoke induce these enzymes. The association of the decrease in the serum FA levels and the increase of the antipyrine clearance rates was investigated. |
| doi_str_mv | 10.1016/0376-8716(83)90079-0 |
| format | Article |
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Lactobacillus casei bioassay. The antipyrine clearance rates were estimated in plasma or saliva obtained after oral administration of antipyrine for evaluating the activity of hepatic microsomal oxidase. The serum FA levels in the smokers were significantly lower than those in the non-smokers and the antipyrine clearance rates were significantly higher in the smokers compared with the non-smokers. The increase of the antipyrine clearance rates in the smokers was supposed to be caused by an increase in the activity of hepatic microsomal oxidase since it has been established that polycyclic aromatic hydrocarbons contained in cigarette smoke induce these enzymes. The association of the decrease in the serum FA levels and the increase of the antipyrine clearance rates was investigated.</description><identifier>ISSN: 0376-8716</identifier><identifier>EISSN: 1879-0046</identifier><identifier>DOI: 10.1016/0376-8716(83)90079-0</identifier><identifier>PMID: 6861617</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Adult ; Antipyrine - blood ; Antipyrine clearance rates ; Folic acid ; Folic Acid - blood ; Hepatic microsomal oxidase ; Humans ; Kinetics ; Male ; Metabolic Clearance Rate ; Microsomes, Liver - drug effects ; Middle Aged ; Smoking</subject><ispartof>Drug and Alcohol Dependence, 1983-04, Vol.11 (2), p.201-207</ispartof><rights>1983</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-e52bb136926e19fcb0a2110cae63811f8f667b727e61c901664d72be2a581e713</citedby><cites>FETCH-LOGICAL-c357t-e52bb136926e19fcb0a2110cae63811f8f667b727e61c901664d72be2a581e713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0376-8716(83)90079-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>313,314,777,781,789,3537,27903,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6861617$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakazawa, Yoichi</creatorcontrib><creatorcontrib>Chiba, Kan</creatorcontrib><creatorcontrib>Imatoh, Nobuhiko</creatorcontrib><creatorcontrib>Kotorii, Tatayu</creatorcontrib><creatorcontrib>Sakamoto, Tetsuro</creatorcontrib><creatorcontrib>Ishizaki, Takashi</creatorcontrib><title>Serum folic acid levels and antipyrine clearance rates in smokers and non-smokers</title><title>Drug and Alcohol Dependence</title><addtitle>Drug Alcohol Depend</addtitle><description>Serum folic acid (FA) levels and antipyrine clearance rates were determined in 15 healthy male subjects who had not been administered any drug and alcohol for a month preceding the study. Eight of the 15 subjects smoked cigarettes daily while the remaining seven did not. The serum FA levels were measured by
Lactobacillus casei bioassay. The antipyrine clearance rates were estimated in plasma or saliva obtained after oral administration of antipyrine for evaluating the activity of hepatic microsomal oxidase. The serum FA levels in the smokers were significantly lower than those in the non-smokers and the antipyrine clearance rates were significantly higher in the smokers compared with the non-smokers. The increase of the antipyrine clearance rates in the smokers was supposed to be caused by an increase in the activity of hepatic microsomal oxidase since it has been established that polycyclic aromatic hydrocarbons contained in cigarette smoke induce these enzymes. The association of the decrease in the serum FA levels and the increase of the antipyrine clearance rates was investigated.</description><subject>Adult</subject><subject>Antipyrine - blood</subject><subject>Antipyrine clearance rates</subject><subject>Folic acid</subject><subject>Folic Acid - blood</subject><subject>Hepatic microsomal oxidase</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Male</subject><subject>Metabolic Clearance Rate</subject><subject>Microsomes, Liver - drug effects</subject><subject>Middle Aged</subject><subject>Smoking</subject><issn>0376-8716</issn><issn>1879-0046</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kNtKxDAQhoMo67r6Bgq5Er2oZnpI0htBFk-wIKJehzSdQrSHNWkX9u1N7bKXBoZkZv75w3yEnAO7AQb8liWCR1IAv5LJdc6YyCN2QOYgxwdL-SGZ7yXH5MT7LxYOz9mMzLjkwEHMyds7uqGhVVdbQ7WxJa1xg7Wnui1D9Ha9dbZFamrUTrcGqdM9empb6pvuG92kbLs22uWn5KjStcez3b0gn48PH8vnaPX69LK8X0UmyUQfYRYXBSQ8jzlCXpmC6RiAGY08kQCVrDgXhYgFcjB52JenpYgLjHUmAQUkC3I5-a5d9zOg71VjvcG61i12g1eSZXHG0zQI00loXOe9w0qtnW202ypgaiSpRkxqxKRkov5IhtKCXOz8h6LBcj-0Qxf6d1M_0MKNRae8sRgIldah6VXZ2f8_-AVXkYH7</recordid><startdate>198304</startdate><enddate>198304</enddate><creator>Nakazawa, Yoichi</creator><creator>Chiba, Kan</creator><creator>Imatoh, Nobuhiko</creator><creator>Kotorii, Tatayu</creator><creator>Sakamoto, Tetsuro</creator><creator>Ishizaki, Takashi</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198304</creationdate><title>Serum folic acid levels and antipyrine clearance rates in smokers and non-smokers</title><author>Nakazawa, Yoichi ; Chiba, Kan ; Imatoh, Nobuhiko ; Kotorii, Tatayu ; Sakamoto, Tetsuro ; Ishizaki, Takashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-e52bb136926e19fcb0a2110cae63811f8f667b727e61c901664d72be2a581e713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Adult</topic><topic>Antipyrine - blood</topic><topic>Antipyrine clearance rates</topic><topic>Folic acid</topic><topic>Folic Acid - blood</topic><topic>Hepatic microsomal oxidase</topic><topic>Humans</topic><topic>Kinetics</topic><topic>Male</topic><topic>Metabolic Clearance Rate</topic><topic>Microsomes, Liver - drug effects</topic><topic>Middle Aged</topic><topic>Smoking</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakazawa, Yoichi</creatorcontrib><creatorcontrib>Chiba, Kan</creatorcontrib><creatorcontrib>Imatoh, Nobuhiko</creatorcontrib><creatorcontrib>Kotorii, Tatayu</creatorcontrib><creatorcontrib>Sakamoto, Tetsuro</creatorcontrib><creatorcontrib>Ishizaki, Takashi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Drug and Alcohol Dependence</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakazawa, Yoichi</au><au>Chiba, Kan</au><au>Imatoh, Nobuhiko</au><au>Kotorii, Tatayu</au><au>Sakamoto, Tetsuro</au><au>Ishizaki, Takashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum folic acid levels and antipyrine clearance rates in smokers and non-smokers</atitle><jtitle>Drug and Alcohol Dependence</jtitle><addtitle>Drug Alcohol Depend</addtitle><date>1983-04</date><risdate>1983</risdate><volume>11</volume><issue>2</issue><spage>201</spage><epage>207</epage><pages>201-207</pages><issn>0376-8716</issn><eissn>1879-0046</eissn><abstract>Serum folic acid (FA) levels and antipyrine clearance rates were determined in 15 healthy male subjects who had not been administered any drug and alcohol for a month preceding the study. Eight of the 15 subjects smoked cigarettes daily while the remaining seven did not. The serum FA levels were measured by
Lactobacillus casei bioassay. The antipyrine clearance rates were estimated in plasma or saliva obtained after oral administration of antipyrine for evaluating the activity of hepatic microsomal oxidase. The serum FA levels in the smokers were significantly lower than those in the non-smokers and the antipyrine clearance rates were significantly higher in the smokers compared with the non-smokers. The increase of the antipyrine clearance rates in the smokers was supposed to be caused by an increase in the activity of hepatic microsomal oxidase since it has been established that polycyclic aromatic hydrocarbons contained in cigarette smoke induce these enzymes. The association of the decrease in the serum FA levels and the increase of the antipyrine clearance rates was investigated.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>6861617</pmid><doi>10.1016/0376-8716(83)90079-0</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0376-8716 |
| ispartof | Drug and Alcohol Dependence, 1983-04, Vol.11 (2), p.201-207 |
| issn | 0376-8716 1879-0046 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Antipyrine - blood Antipyrine clearance rates Folic acid Folic Acid - blood Hepatic microsomal oxidase Humans Kinetics Male Metabolic Clearance Rate Microsomes, Liver - drug effects Middle Aged Smoking |
| title | Serum folic acid levels and antipyrine clearance rates in smokers and non-smokers |
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