Experimental studies on the radiation‐modifying effect of cis‐diamminedichloroplatinum II (DDP) in human bladder transitional cell carcinomas grown in nude mice
The effect of cis‐diamminedichloroplatinum II (DDP) and ionizing radiation on human bladder transitional cell carcinoma (TCC) was evaluated in nude mouse‐grown human tumors following administration of single‐agent and combination treatment. Combination of DDP and radiation resulted in accelerated tu...
Gespeichert in:
| Veröffentlicht in: | Cancer 1983-08, Vol.52 (3), p.452-457 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 457 |
|---|---|
| container_issue | 3 |
| container_start_page | 452 |
| container_title | Cancer |
| container_volume | 52 |
| creator | Kyriazis, Andreas P. Yagoda, Alan Kereiakes, James G. Kyriazis, Aikaterini A. Whitmore, Willet F. |
| description | The effect of cis‐diamminedichloroplatinum II (DDP) and ionizing radiation on human bladder transitional cell carcinoma (TCC) was evaluated in nude mouse‐grown human tumors following administration of single‐agent and combination treatment. Combination of DDP and radiation resulted in accelerated tumor regression and substantially delayed tumor regrowth. The potentiating effect of DDP on ionizing radiation was related to timing and sequence of treatments and was independent of tumor sensitivity to DDP. Best results, as judged by tumor growth curve characteristics, histopathologic changes, and absence of tumor metastases, were obtained when DDP was administered at an early stage following radiation treatment. |
| doi_str_mv | 10.1002/1097-0142(19830801)52:3<452::AID-CNCR2820520312>3.0.CO;2-P |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80522475</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>80522475</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4662-7bf5a9999aeabecf1dc9b3d774441135d4aa26068e02192d38bf7e5fb059a6e73</originalsourceid><addsrcrecordid>eNqVkd9qFDEUxoModVt9BCFX0l7Mmj_zt4pQZ6suFHcRBfEmZCZnupFJsiYztHvnI_gQPplPYoZdC3ohmIsTwne-7xzyQ-gVJXNKCHtGSVUkhKbslFYlJyWhZxk75y_SWM8vloukfle_ZyUjGSOcspd8Tub16jlL1vfQ7M58H80IIWWSpfzTQ3Qcwpf4LFjGj9BRnpfRSGbox-XtFrw2YAfZ4zCMSkPAzuJhA9hLpeWgnf357btxSnc7ba8xdB20A3YdbnWISuwxRltQut30zrttHz12NHi5xKeLxfoMa4s3o5EWN71UCjwevLRBT8lxaAt9LNK32jojA7727sZOHjsqwEa38Ag96GQf4PHhPkEfX19-qN8mV6s3y_riKmnTPGdJ0XSZrOKRIBtoO6raquGqKNI0pZRnKpWS5SQvgTBaMcXLpisg6xqSVTKHgp-gp_vcrXdfRwiDMDpM60kLbgyijB_O0iKLjZ_3ja13IXjoxDb-ofQ7QYmYEIqJgpgoiN8IRcYEFxGhEBGh-BNhVIioV4KJdQx_cthibAyou-gDs6jDXr_RPez-a_I_B_-l8F9Vwr48</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>80522475</pqid></control><display><type>article</type><title>Experimental studies on the radiation‐modifying effect of cis‐diamminedichloroplatinum II (DDP) in human bladder transitional cell carcinomas grown in nude mice</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Kyriazis, Andreas P. ; Yagoda, Alan ; Kereiakes, James G. ; Kyriazis, Aikaterini A. ; Whitmore, Willet F.</creator><creatorcontrib>Kyriazis, Andreas P. ; Yagoda, Alan ; Kereiakes, James G. ; Kyriazis, Aikaterini A. ; Whitmore, Willet F.</creatorcontrib><description>The effect of cis‐diamminedichloroplatinum II (DDP) and ionizing radiation on human bladder transitional cell carcinoma (TCC) was evaluated in nude mouse‐grown human tumors following administration of single‐agent and combination treatment. Combination of DDP and radiation resulted in accelerated tumor regression and substantially delayed tumor regrowth. The potentiating effect of DDP on ionizing radiation was related to timing and sequence of treatments and was independent of tumor sensitivity to DDP. Best results, as judged by tumor growth curve characteristics, histopathologic changes, and absence of tumor metastases, were obtained when DDP was administered at an early stage following radiation treatment.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(19830801)52:3<452::AID-CNCR2820520312>3.0.CO;2-P</identifier><identifier>PMID: 6683120</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Aged ; Animals ; Body Weight ; Carcinoma, Transitional Cell - drug therapy ; Carcinoma, Transitional Cell - pathology ; Carcinoma, Transitional Cell - radiotherapy ; Cisplatin - therapeutic use ; Female ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Middle Aged ; Neoplasm Transplantation ; Neoplasms, Experimental - drug therapy ; Neoplasms, Experimental - pathology ; Neoplasms, Experimental - radiotherapy ; Radiotherapy Dosage ; Urinary Bladder Neoplasms - drug therapy ; Urinary Bladder Neoplasms - pathology ; Urinary Bladder Neoplasms - radiotherapy</subject><ispartof>Cancer, 1983-08, Vol.52 (3), p.452-457</ispartof><rights>Copyright © 1983 American Cancer Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4662-7bf5a9999aeabecf1dc9b3d774441135d4aa26068e02192d38bf7e5fb059a6e73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6683120$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kyriazis, Andreas P.</creatorcontrib><creatorcontrib>Yagoda, Alan</creatorcontrib><creatorcontrib>Kereiakes, James G.</creatorcontrib><creatorcontrib>Kyriazis, Aikaterini A.</creatorcontrib><creatorcontrib>Whitmore, Willet F.</creatorcontrib><title>Experimental studies on the radiation‐modifying effect of cis‐diamminedichloroplatinum II (DDP) in human bladder transitional cell carcinomas grown in nude mice</title><title>Cancer</title><addtitle>Cancer</addtitle><description>The effect of cis‐diamminedichloroplatinum II (DDP) and ionizing radiation on human bladder transitional cell carcinoma (TCC) was evaluated in nude mouse‐grown human tumors following administration of single‐agent and combination treatment. Combination of DDP and radiation resulted in accelerated tumor regression and substantially delayed tumor regrowth. The potentiating effect of DDP on ionizing radiation was related to timing and sequence of treatments and was independent of tumor sensitivity to DDP. Best results, as judged by tumor growth curve characteristics, histopathologic changes, and absence of tumor metastases, were obtained when DDP was administered at an early stage following radiation treatment.</description><subject>Aged</subject><subject>Animals</subject><subject>Body Weight</subject><subject>Carcinoma, Transitional Cell - drug therapy</subject><subject>Carcinoma, Transitional Cell - pathology</subject><subject>Carcinoma, Transitional Cell - radiotherapy</subject><subject>Cisplatin - therapeutic use</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Nude</subject><subject>Middle Aged</subject><subject>Neoplasm Transplantation</subject><subject>Neoplasms, Experimental - drug therapy</subject><subject>Neoplasms, Experimental - pathology</subject><subject>Neoplasms, Experimental - radiotherapy</subject><subject>Radiotherapy Dosage</subject><subject>Urinary Bladder Neoplasms - drug therapy</subject><subject>Urinary Bladder Neoplasms - pathology</subject><subject>Urinary Bladder Neoplasms - radiotherapy</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkd9qFDEUxoModVt9BCFX0l7Mmj_zt4pQZ6suFHcRBfEmZCZnupFJsiYztHvnI_gQPplPYoZdC3ohmIsTwne-7xzyQ-gVJXNKCHtGSVUkhKbslFYlJyWhZxk75y_SWM8vloukfle_ZyUjGSOcspd8Tub16jlL1vfQ7M58H80IIWWSpfzTQ3Qcwpf4LFjGj9BRnpfRSGbox-XtFrw2YAfZ4zCMSkPAzuJhA9hLpeWgnf357btxSnc7ba8xdB20A3YdbnWISuwxRltQut30zrttHz12NHi5xKeLxfoMa4s3o5EWN71UCjwevLRBT8lxaAt9LNK32jojA7727sZOHjsqwEa38Ag96GQf4PHhPkEfX19-qN8mV6s3y_riKmnTPGdJ0XSZrOKRIBtoO6raquGqKNI0pZRnKpWS5SQvgTBaMcXLpisg6xqSVTKHgp-gp_vcrXdfRwiDMDpM60kLbgyijB_O0iKLjZ_3ja13IXjoxDb-ofQ7QYmYEIqJgpgoiN8IRcYEFxGhEBGh-BNhVIioV4KJdQx_cthibAyou-gDs6jDXr_RPez-a_I_B_-l8F9Vwr48</recordid><startdate>19830801</startdate><enddate>19830801</enddate><creator>Kyriazis, Andreas P.</creator><creator>Yagoda, Alan</creator><creator>Kereiakes, James G.</creator><creator>Kyriazis, Aikaterini A.</creator><creator>Whitmore, Willet F.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19830801</creationdate><title>Experimental studies on the radiation‐modifying effect of cis‐diamminedichloroplatinum II (DDP) in human bladder transitional cell carcinomas grown in nude mice</title><author>Kyriazis, Andreas P. ; Yagoda, Alan ; Kereiakes, James G. ; Kyriazis, Aikaterini A. ; Whitmore, Willet F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4662-7bf5a9999aeabecf1dc9b3d774441135d4aa26068e02192d38bf7e5fb059a6e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Aged</topic><topic>Animals</topic><topic>Body Weight</topic><topic>Carcinoma, Transitional Cell - drug therapy</topic><topic>Carcinoma, Transitional Cell - pathology</topic><topic>Carcinoma, Transitional Cell - radiotherapy</topic><topic>Cisplatin - therapeutic use</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Nude</topic><topic>Middle Aged</topic><topic>Neoplasm Transplantation</topic><topic>Neoplasms, Experimental - drug therapy</topic><topic>Neoplasms, Experimental - pathology</topic><topic>Neoplasms, Experimental - radiotherapy</topic><topic>Radiotherapy Dosage</topic><topic>Urinary Bladder Neoplasms - drug therapy</topic><topic>Urinary Bladder Neoplasms - pathology</topic><topic>Urinary Bladder Neoplasms - radiotherapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kyriazis, Andreas P.</creatorcontrib><creatorcontrib>Yagoda, Alan</creatorcontrib><creatorcontrib>Kereiakes, James G.</creatorcontrib><creatorcontrib>Kyriazis, Aikaterini A.</creatorcontrib><creatorcontrib>Whitmore, Willet F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kyriazis, Andreas P.</au><au>Yagoda, Alan</au><au>Kereiakes, James G.</au><au>Kyriazis, Aikaterini A.</au><au>Whitmore, Willet F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental studies on the radiation‐modifying effect of cis‐diamminedichloroplatinum II (DDP) in human bladder transitional cell carcinomas grown in nude mice</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1983-08-01</date><risdate>1983</risdate><volume>52</volume><issue>3</issue><spage>452</spage><epage>457</epage><pages>452-457</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><abstract>The effect of cis‐diamminedichloroplatinum II (DDP) and ionizing radiation on human bladder transitional cell carcinoma (TCC) was evaluated in nude mouse‐grown human tumors following administration of single‐agent and combination treatment. Combination of DDP and radiation resulted in accelerated tumor regression and substantially delayed tumor regrowth. The potentiating effect of DDP on ionizing radiation was related to timing and sequence of treatments and was independent of tumor sensitivity to DDP. Best results, as judged by tumor growth curve characteristics, histopathologic changes, and absence of tumor metastases, were obtained when DDP was administered at an early stage following radiation treatment.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>6683120</pmid><doi>10.1002/1097-0142(19830801)52:3<452::AID-CNCR2820520312>3.0.CO;2-P</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0008-543X |
| ispartof | Cancer, 1983-08, Vol.52 (3), p.452-457 |
| issn | 0008-543X 1097-0142 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80522475 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Aged Animals Body Weight Carcinoma, Transitional Cell - drug therapy Carcinoma, Transitional Cell - pathology Carcinoma, Transitional Cell - radiotherapy Cisplatin - therapeutic use Female Humans Male Mice Mice, Inbred BALB C Mice, Nude Middle Aged Neoplasm Transplantation Neoplasms, Experimental - drug therapy Neoplasms, Experimental - pathology Neoplasms, Experimental - radiotherapy Radiotherapy Dosage Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - pathology Urinary Bladder Neoplasms - radiotherapy |
| title | Experimental studies on the radiation‐modifying effect of cis‐diamminedichloroplatinum II (DDP) in human bladder transitional cell carcinomas grown in nude mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T12%3A24%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Experimental%20studies%20on%20the%20radiation%E2%80%90modifying%20effect%20of%20cis%E2%80%90diamminedichloroplatinum%20II%20(DDP)%20in%20human%20bladder%20transitional%20cell%20carcinomas%20grown%20in%20nude%20mice&rft.jtitle=Cancer&rft.au=Kyriazis,%20Andreas%20P.&rft.date=1983-08-01&rft.volume=52&rft.issue=3&rft.spage=452&rft.epage=457&rft.pages=452-457&rft.issn=0008-543X&rft.eissn=1097-0142&rft_id=info:doi/10.1002/1097-0142(19830801)52:3%3C452::AID-CNCR2820520312%3E3.0.CO;2-P&rft_dat=%3Cproquest_cross%3E80522475%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=80522475&rft_id=info:pmid/6683120&rfr_iscdi=true |