The inhibitory activity of a peptide derivative against the growth of simian immunodeficiency virus in C8166 cells
The peptide derivative Ro 31-8959 is a potent and selective inhibitor of the aspartic proteinases encoded by HIV-1 and HIV-2 and it arrests the growth of both viruses in cell culture. We have demonstrated similar effects against the simian immunodeficiency virus SIV mac251 in the human T-cell line,...
Gespeichert in:
| Veröffentlicht in: | Biochemical and biophysical research communications 1991-04, Vol.176 (1), p.180-188 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 188 |
|---|---|
| container_issue | 1 |
| container_start_page | 180 |
| container_title | Biochemical and biophysical research communications |
| container_volume | 176 |
| creator | Martin, Joseph A. Mobberley, Margaret A. Redshaw, Sally Burke, Andy Tyms, A.Stanley Ryder, Timothy A. |
| description | The peptide derivative Ro 31-8959 is a potent and selective inhibitor of the aspartic proteinases encoded by HIV-1 and HIV-2 and it arrests the growth of both viruses in cell culture. We have demonstrated similar effects against the simian immunodeficiency virus SIV
mac251 in the human T-cell line, C8166 (ED
50 = 6nM) with a therapeutic index of 4,500. The antiviral activity of Ro 31-8959 was 250 and 22 times greater than that of ddI and ddC, respectively. The mode of action was confirmed by accumulation of the polyprotein p55 with concomitant reduction of the cleavage product, p27, and by the production of immature virions. |
| doi_str_mv | 10.1016/0006-291X(91)90906-N |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80520909</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0006291X9190906N</els_id><sourcerecordid>80520909</sourcerecordid><originalsourceid>FETCH-LOGICAL-c418t-94a1f81158fa724bbe888c77b79bf9b5c4961e59fa71b54d46a1d8f4453febec3</originalsourceid><addsrcrecordid>eNqFkU-LFDEQxYMo67j6DRRyUfQwmupJMslFkMF_sKyXFbyFdLqyUzLdPSbpkfn2pncG96anVHi_VxTvMfYcxFsQoN8JIfSysfDjtYU3Vtj6u37AFlCnZQNCPmSLv8hj9iTnn0IASG0v2AUYJRqlFyzdbJHTsKWWypiO3IdCBypHPkbu-R73hTrkHSY6-Kog97eehlx4qb7bNP4u2xnN1JMfOPX9NIwdRgqEQzjyA6Up1_18Y0BrHnC3y0_Zo-h3GZ-d30v2_dPHm82X5dW3z183H66WQYIpSys9RAOgTPTrRrYtGmPCet2ubRttq4K0GlDZqkKrZCe1h85EKdUqYothdclenfbu0_hrwlxcT3m-wA84TtkZoZqalf0vCFoZ2YCsoDyBIY05J4xun6j36ehAuLkTNwfu5sCdBXfXibuuthfn_VPbY3dvOpVQ9Zdn3efgdzH5IVC-x6xeGaVF5d6fOKypHQiTy3cxY0cJQ3HdSP8-5A9xMKmW</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16584214</pqid></control><display><type>article</type><title>The inhibitory activity of a peptide derivative against the growth of simian immunodeficiency virus in C8166 cells</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Martin, Joseph A. ; Mobberley, Margaret A. ; Redshaw, Sally ; Burke, Andy ; Tyms, A.Stanley ; Ryder, Timothy A.</creator><creatorcontrib>Martin, Joseph A. ; Mobberley, Margaret A. ; Redshaw, Sally ; Burke, Andy ; Tyms, A.Stanley ; Ryder, Timothy A.</creatorcontrib><description>The peptide derivative Ro 31-8959 is a potent and selective inhibitor of the aspartic proteinases encoded by HIV-1 and HIV-2 and it arrests the growth of both viruses in cell culture. We have demonstrated similar effects against the simian immunodeficiency virus SIV
mac251 in the human T-cell line, C8166 (ED
50 = 6nM) with a therapeutic index of 4,500. The antiviral activity of Ro 31-8959 was 250 and 22 times greater than that of ddI and ddC, respectively. The mode of action was confirmed by accumulation of the polyprotein p55 with concomitant reduction of the cleavage product, p27, and by the production of immature virions.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/0006-291X(91)90906-N</identifier><identifier>PMID: 1850256</identifier><identifier>CODEN: BBRCA9</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>AIDS/HIV ; Animals ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiviral agents ; Antiviral Agents - pharmacology ; Biological and medical sciences ; Cell Line ; Didanosine - pharmacology ; HIV Protease - pharmacology ; HIV Protease Inhibitors ; Humans ; Medical sciences ; Microscopy, Electron ; Pharmacology. Drug treatments ; Saquinavir ; simian immunodeficiency virus ; Simian Immunodeficiency Virus - drug effects ; Simian Immunodeficiency Virus - growth & development ; Simian Immunodeficiency Virus - ultrastructure ; Zalcitabine - pharmacology</subject><ispartof>Biochemical and biophysical research communications, 1991-04, Vol.176 (1), p.180-188</ispartof><rights>1991</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-94a1f81158fa724bbe888c77b79bf9b5c4961e59fa71b54d46a1d8f4453febec3</citedby><cites>FETCH-LOGICAL-c418t-94a1f81158fa724bbe888c77b79bf9b5c4961e59fa71b54d46a1d8f4453febec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-291X(91)90906-N$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19638560$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1850256$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Martin, Joseph A.</creatorcontrib><creatorcontrib>Mobberley, Margaret A.</creatorcontrib><creatorcontrib>Redshaw, Sally</creatorcontrib><creatorcontrib>Burke, Andy</creatorcontrib><creatorcontrib>Tyms, A.Stanley</creatorcontrib><creatorcontrib>Ryder, Timothy A.</creatorcontrib><title>The inhibitory activity of a peptide derivative against the growth of simian immunodeficiency virus in C8166 cells</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>The peptide derivative Ro 31-8959 is a potent and selective inhibitor of the aspartic proteinases encoded by HIV-1 and HIV-2 and it arrests the growth of both viruses in cell culture. We have demonstrated similar effects against the simian immunodeficiency virus SIV
mac251 in the human T-cell line, C8166 (ED
50 = 6nM) with a therapeutic index of 4,500. The antiviral activity of Ro 31-8959 was 250 and 22 times greater than that of ddI and ddC, respectively. The mode of action was confirmed by accumulation of the polyprotein p55 with concomitant reduction of the cleavage product, p27, and by the production of immature virions.</description><subject>AIDS/HIV</subject><subject>Animals</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiviral agents</subject><subject>Antiviral Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cell Line</subject><subject>Didanosine - pharmacology</subject><subject>HIV Protease - pharmacology</subject><subject>HIV Protease Inhibitors</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Microscopy, Electron</subject><subject>Pharmacology. Drug treatments</subject><subject>Saquinavir</subject><subject>simian immunodeficiency virus</subject><subject>Simian Immunodeficiency Virus - drug effects</subject><subject>Simian Immunodeficiency Virus - growth & development</subject><subject>Simian Immunodeficiency Virus - ultrastructure</subject><subject>Zalcitabine - pharmacology</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU-LFDEQxYMo67j6DRRyUfQwmupJMslFkMF_sKyXFbyFdLqyUzLdPSbpkfn2pncG96anVHi_VxTvMfYcxFsQoN8JIfSysfDjtYU3Vtj6u37AFlCnZQNCPmSLv8hj9iTnn0IASG0v2AUYJRqlFyzdbJHTsKWWypiO3IdCBypHPkbu-R73hTrkHSY6-Kog97eehlx4qb7bNP4u2xnN1JMfOPX9NIwdRgqEQzjyA6Up1_18Y0BrHnC3y0_Zo-h3GZ-d30v2_dPHm82X5dW3z183H66WQYIpSys9RAOgTPTrRrYtGmPCet2ubRttq4K0GlDZqkKrZCe1h85EKdUqYothdclenfbu0_hrwlxcT3m-wA84TtkZoZqalf0vCFoZ2YCsoDyBIY05J4xun6j36ehAuLkTNwfu5sCdBXfXibuuthfn_VPbY3dvOpVQ9Zdn3efgdzH5IVC-x6xeGaVF5d6fOKypHQiTy3cxY0cJQ3HdSP8-5A9xMKmW</recordid><startdate>19910415</startdate><enddate>19910415</enddate><creator>Martin, Joseph A.</creator><creator>Mobberley, Margaret A.</creator><creator>Redshaw, Sally</creator><creator>Burke, Andy</creator><creator>Tyms, A.Stanley</creator><creator>Ryder, Timothy A.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19910415</creationdate><title>The inhibitory activity of a peptide derivative against the growth of simian immunodeficiency virus in C8166 cells</title><author>Martin, Joseph A. ; Mobberley, Margaret A. ; Redshaw, Sally ; Burke, Andy ; Tyms, A.Stanley ; Ryder, Timothy A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-94a1f81158fa724bbe888c77b79bf9b5c4961e59fa71b54d46a1d8f4453febec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>AIDS/HIV</topic><topic>Animals</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antiviral agents</topic><topic>Antiviral Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cell Line</topic><topic>Didanosine - pharmacology</topic><topic>HIV Protease - pharmacology</topic><topic>HIV Protease Inhibitors</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Microscopy, Electron</topic><topic>Pharmacology. Drug treatments</topic><topic>Saquinavir</topic><topic>simian immunodeficiency virus</topic><topic>Simian Immunodeficiency Virus - drug effects</topic><topic>Simian Immunodeficiency Virus - growth & development</topic><topic>Simian Immunodeficiency Virus - ultrastructure</topic><topic>Zalcitabine - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martin, Joseph A.</creatorcontrib><creatorcontrib>Mobberley, Margaret A.</creatorcontrib><creatorcontrib>Redshaw, Sally</creatorcontrib><creatorcontrib>Burke, Andy</creatorcontrib><creatorcontrib>Tyms, A.Stanley</creatorcontrib><creatorcontrib>Ryder, Timothy A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martin, Joseph A.</au><au>Mobberley, Margaret A.</au><au>Redshaw, Sally</au><au>Burke, Andy</au><au>Tyms, A.Stanley</au><au>Ryder, Timothy A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The inhibitory activity of a peptide derivative against the growth of simian immunodeficiency virus in C8166 cells</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1991-04-15</date><risdate>1991</risdate><volume>176</volume><issue>1</issue><spage>180</spage><epage>188</epage><pages>180-188</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><coden>BBRCA9</coden><abstract>The peptide derivative Ro 31-8959 is a potent and selective inhibitor of the aspartic proteinases encoded by HIV-1 and HIV-2 and it arrests the growth of both viruses in cell culture. We have demonstrated similar effects against the simian immunodeficiency virus SIV
mac251 in the human T-cell line, C8166 (ED
50 = 6nM) with a therapeutic index of 4,500. The antiviral activity of Ro 31-8959 was 250 and 22 times greater than that of ddI and ddC, respectively. The mode of action was confirmed by accumulation of the polyprotein p55 with concomitant reduction of the cleavage product, p27, and by the production of immature virions.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>1850256</pmid><doi>10.1016/0006-291X(91)90906-N</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-291X |
| ispartof | Biochemical and biophysical research communications, 1991-04, Vol.176 (1), p.180-188 |
| issn | 0006-291X 1090-2104 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80520909 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | AIDS/HIV Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - pharmacology Biological and medical sciences Cell Line Didanosine - pharmacology HIV Protease - pharmacology HIV Protease Inhibitors Humans Medical sciences Microscopy, Electron Pharmacology. Drug treatments Saquinavir simian immunodeficiency virus Simian Immunodeficiency Virus - drug effects Simian Immunodeficiency Virus - growth & development Simian Immunodeficiency Virus - ultrastructure Zalcitabine - pharmacology |
| title | The inhibitory activity of a peptide derivative against the growth of simian immunodeficiency virus in C8166 cells |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T06%3A29%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20inhibitory%20activity%20of%20a%20peptide%20derivative%20against%20the%20growth%20of%20simian%20immunodeficiency%20virus%20in%20C8166%20cells&rft.jtitle=Biochemical%20and%20biophysical%20research%20communications&rft.au=Martin,%20Joseph%20A.&rft.date=1991-04-15&rft.volume=176&rft.issue=1&rft.spage=180&rft.epage=188&rft.pages=180-188&rft.issn=0006-291X&rft.eissn=1090-2104&rft.coden=BBRCA9&rft_id=info:doi/10.1016/0006-291X(91)90906-N&rft_dat=%3Cproquest_cross%3E80520909%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16584214&rft_id=info:pmid/1850256&rft_els_id=0006291X9190906N&rfr_iscdi=true |