New inhibitors of human renin that contain novel replacements at the P2 site

A series of renin inhibitors with novel modifications at the P2 site has been prepared. Structure-activity relationships reveal that for a particular P2 fragment the in vitro potency is highly dependent on the nature of the P2' portion in addition to the P1-P1' group. The length of the P2...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 1991-04, Vol.34 (4), p.1258-1271
Hauptverfasser:	Doherty, Annette M, Kaltenbronn, James S, Hudspeth, James P, Repine, Joseph T, Roark, William H, Sircar, Ila, Tinney, Frank J, Connolly, Cleo J, Hodges, John C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antihypertensive Agents - chemical synthesis Antihypertensive Agents - chemistry Antihypertensive Agents - pharmacology Binding Sites Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - pharmacology Kinetics Lysine Macaca fascicularis Male Models, Molecular Molecular Conformation Molecular Structure Renin - antagonists & inhibitors Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!