Activation of the cellular oncogene c-erbB by ltr insertion: Molecular basis for induction of erythroblastosis by avian leukosis virus

Avian leukosis virus (ALV), a slowly oncogenic retrovirus, induces in chickens a variety of neoplasms, including lymphoid leukosis and erythroblastosis. In lymphoid leukosis, a cellular oncogene, c-myc, is activated by the insertion of ALV LTR. We provide evidence that ALV utilizes a similar mechani...

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Veröffentlicht in:	Cell 1983-06, Vol.33 (2), p.357-368
Hauptverfasser:	Fung, Yuen-Kai T., Lewis, Wynne G., Crittenden, Lyman B., Kung, Hsing-Jien
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Avian Leukosis - genetics avian leukosis virus Avian Leukosis Virus - genetics Base Sequence Chickens Cloning, Molecular Deoxyribonuclease EcoRI DNA Restriction Enzymes - metabolism DNA, Viral - physiology Oncogenes Operon Poultry Diseases - genetics
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