Activation of the cellular oncogene c-erbB by ltr insertion: Molecular basis for induction of erythroblastosis by avian leukosis virus
Avian leukosis virus (ALV), a slowly oncogenic retrovirus, induces in chickens a variety of neoplasms, including lymphoid leukosis and erythroblastosis. In lymphoid leukosis, a cellular oncogene, c-myc, is activated by the insertion of ALV LTR. We provide evidence that ALV utilizes a similar mechani...
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| Veröffentlicht in: | Cell 1983-06, Vol.33 (2), p.357-368 |
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| container_end_page | 368 |
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| creator | Fung, Yuen-Kai T. Lewis, Wynne G. Crittenden, Lyman B. Kung, Hsing-Jien |
| description | Avian leukosis virus (ALV), a slowly oncogenic retrovirus, induces in chickens a variety of neoplasms, including lymphoid leukosis and erythroblastosis. In lymphoid leukosis, a cellular oncogene, c-myc, is activated by the insertion of ALV LTR. We provide evidence that ALV utilizes a similar mechanism in erythroblastosis induction by activating a different cellular oncogene, c-erbB. We report the isolation, from leukemic erythroblast DNA, of a clone that represents the viral-cell junction fragment and carried the ALV LTR and part of the c-erbB locus. Restriction and sequence analyses reveal that the LTR is located upstream from the erbB coding region and is oriented in the same transcriptional direction; such a structure would be compatible with the promoter-insertion type of activation. Our findings provide a molecular explanation for the multipotency of slowly oncogenic retroviruses. |
| doi_str_mv | 10.1016/0092-8674(83)90417-8 |
| format | Article |
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Our findings provide a molecular explanation for the multipotency of slowly oncogenic retroviruses.</description><subject>Animals</subject><subject>Avian Leukosis - genetics</subject><subject>avian leukosis virus</subject><subject>Avian Leukosis Virus - genetics</subject><subject>Base Sequence</subject><subject>Chickens</subject><subject>Cloning, Molecular</subject><subject>Deoxyribonuclease EcoRI</subject><subject>DNA Restriction Enzymes - metabolism</subject><subject>DNA, Viral - physiology</subject><subject>Oncogenes</subject><subject>Operon</subject><subject>Poultry Diseases - genetics</subject><issn>0092-8674</issn><issn>1097-4172</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1uEzEUhS0EKmngDQB5hcpiwI7_WSCVCtpKRSyga8tjX7eGybi1ZyLlBXhuZpK0S1j5-p7vHtn3IPSKkveUUPmBELNqtFT8RLN3hnCqGv0ELSgxqpkuq6do8Yg8R8e1_iKEaCHEETqSjAhBxAL9OfVD2rgh5R7niIdbwB66buxcwbn3-Qb6qdNAaT_jdou7oeDUVyjzwEf8LXfgd2zraqo45lkOo3_wg7IdbktuO1eHPBOTh9sk1-MOxt-7ziaVsb5Az6LrKrw8nEt0_fXLz7OL5ur7-eXZ6VXjuVBDo7xQgRlQ3MTAORcytHHlqTErZaSHVnJgXkgSdSTMSx6iD8w5pSNTAVq2RG_3vncl349QB7tOdf6w6yGP1WoiqNaa_xekTFFJhJxAvgd9ybUWiPaupLUrW0uJnXOycwh2DsFqZnc5TcUSvT74j-0awuPQIZhJf7PXo8vW3ZRU7fUPajQnhAtDZoNPewCmdW0SFFt9gt5DSAX8YENO_37BX8QHrcQ</recordid><startdate>198306</startdate><enddate>198306</enddate><creator>Fung, Yuen-Kai T.</creator><creator>Lewis, Wynne G.</creator><creator>Crittenden, Lyman B.</creator><creator>Kung, Hsing-Jien</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>198306</creationdate><title>Activation of the cellular oncogene c-erbB by ltr insertion: Molecular basis for induction of erythroblastosis by avian leukosis virus</title><author>Fung, Yuen-Kai T. ; Lewis, Wynne G. ; Crittenden, Lyman B. ; Kung, Hsing-Jien</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-7c57d39e749fd44456dbf2c1992796ceb64e3c560f8f03c64dfcd3aa78f37deb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Animals</topic><topic>Avian Leukosis - genetics</topic><topic>avian leukosis virus</topic><topic>Avian Leukosis Virus - genetics</topic><topic>Base Sequence</topic><topic>Chickens</topic><topic>Cloning, Molecular</topic><topic>Deoxyribonuclease EcoRI</topic><topic>DNA Restriction Enzymes - metabolism</topic><topic>DNA, Viral - physiology</topic><topic>Oncogenes</topic><topic>Operon</topic><topic>Poultry Diseases - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fung, Yuen-Kai T.</creatorcontrib><creatorcontrib>Lewis, Wynne G.</creatorcontrib><creatorcontrib>Crittenden, Lyman B.</creatorcontrib><creatorcontrib>Kung, Hsing-Jien</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fung, Yuen-Kai T.</au><au>Lewis, Wynne G.</au><au>Crittenden, Lyman B.</au><au>Kung, Hsing-Jien</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Activation of the cellular oncogene c-erbB by ltr insertion: Molecular basis for induction of erythroblastosis by avian leukosis virus</atitle><jtitle>Cell</jtitle><addtitle>Cell</addtitle><date>1983-06</date><risdate>1983</risdate><volume>33</volume><issue>2</issue><spage>357</spage><epage>368</epage><pages>357-368</pages><issn>0092-8674</issn><eissn>1097-4172</eissn><abstract>Avian leukosis virus (ALV), a slowly oncogenic retrovirus, induces in chickens a variety of neoplasms, including lymphoid leukosis and erythroblastosis. In lymphoid leukosis, a cellular oncogene, c-myc, is activated by the insertion of ALV LTR. We provide evidence that ALV utilizes a similar mechanism in erythroblastosis induction by activating a different cellular oncogene, c-erbB. We report the isolation, from leukemic erythroblast DNA, of a clone that represents the viral-cell junction fragment and carried the ALV LTR and part of the c-erbB locus. Restriction and sequence analyses reveal that the LTR is located upstream from the erbB coding region and is oriented in the same transcriptional direction; such a structure would be compatible with the promoter-insertion type of activation. Our findings provide a molecular explanation for the multipotency of slowly oncogenic retroviruses.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>6305505</pmid><doi>10.1016/0092-8674(83)90417-8</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cell, 1983-06, Vol.33 (2), p.357-368 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Avian Leukosis - genetics avian leukosis virus Avian Leukosis Virus - genetics Base Sequence Chickens Cloning, Molecular Deoxyribonuclease EcoRI DNA Restriction Enzymes - metabolism DNA, Viral - physiology Oncogenes Operon Poultry Diseases - genetics |
| title | Activation of the cellular oncogene c-erbB by ltr insertion: Molecular basis for induction of erythroblastosis by avian leukosis virus |
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