Sister chromatid exchange: Variation by age, sex, smoking, and breast cancer status

Variation in sister chromatid exchange (SCE) frequency in lymphocytes of 125 persons was compared using a multivariate general linear model. The study was performed to determine whether SCE frequency differs with respect to age, sex, smoking, and breast cancer status. Study subjects were divided int...

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Veröffentlicht in:Cancer genetics and cytogenetics 1983-07, Vol.9 (3), p.289-299
Hauptverfasser: Livingston, Gordon K., Cannon, Lisa A., Timothy Bishop, D., Johnson, Penny, Fineman, Robert M.
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container_end_page 299
container_issue 3
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container_title Cancer genetics and cytogenetics
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creator Livingston, Gordon K.
Cannon, Lisa A.
Timothy Bishop, D.
Johnson, Penny
Fineman, Robert M.
description Variation in sister chromatid exchange (SCE) frequency in lymphocytes of 125 persons was compared using a multivariate general linear model. The study was performed to determine whether SCE frequency differs with respect to age, sex, smoking, and breast cancer status. Study subjects were divided into: members of two branches of families having an excess of cancer (primarily breast) including a brother and sister in one family who developed nonbreast malignancies within 1 yr of the study; women in both families successfully treated for breast cancer (all at least 5 yr posttreatment); and women from the general population with confirmed breast cancer. Controls consisted of spouses who married into the high-risk kindreds, hospital personnel, and others (primarily tradesmen without history of occupational exposure). Results show that: (1) Women with active breast cancer have a significantly higher mean SCE frequency than control women or women greater than 5 yr posttreatment for breast cancer; (2) Cigarette smokers show a significantly higher number of SCEs than was observed in nonsmokers; (3) The increase in SCE level in smokers is dose-related to exposure as measured by cumulative pack-years; (4) SCE values in both high-risk families are not significantly different from controls; (5) Neither the age nor sex of the individual affects SCE frequency; and (6) The observed distribution of exchanges agrees with that expected based on the proportion of the genome represented by each chromosome group.
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source MEDLINE; Access via ScienceDirect (Elsevier)
subjects Adult
Age Factors
Aged
Breast Neoplasms - genetics
Crossing Over, Genetic
Female
Humans
Lymphocytes - ultrastructure
Male
Middle Aged
Models, Biological
Risk
Sex Factors
Sister Chromatid Exchange
Smoking
title Sister chromatid exchange: Variation by age, sex, smoking, and breast cancer status
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