Sister chromatid exchange: Variation by age, sex, smoking, and breast cancer status
Variation in sister chromatid exchange (SCE) frequency in lymphocytes of 125 persons was compared using a multivariate general linear model. The study was performed to determine whether SCE frequency differs with respect to age, sex, smoking, and breast cancer status. Study subjects were divided int...
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Veröffentlicht in: | Cancer genetics and cytogenetics 1983-07, Vol.9 (3), p.289-299 |
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description | Variation in sister chromatid exchange (SCE) frequency in lymphocytes of 125 persons was compared using a multivariate general linear model. The study was performed to determine whether SCE frequency differs with respect to age, sex, smoking, and breast cancer status. Study subjects were divided into: members of two branches of families having an excess of cancer (primarily breast) including a brother and sister in one family who developed nonbreast malignancies within 1 yr of the study; women in both families successfully treated for breast cancer (all at least 5 yr posttreatment); and women from the general population with confirmed breast cancer.
Controls consisted of spouses who married into the high-risk kindreds, hospital personnel, and others (primarily tradesmen without history of occupational exposure). Results show that: (1) Women with active breast cancer have a significantly higher mean SCE frequency than control women or women greater than 5 yr posttreatment for breast cancer; (2) Cigarette smokers show a significantly higher number of SCEs than was observed in nonsmokers; (3) The increase in SCE level in smokers is dose-related to exposure as measured by cumulative pack-years; (4) SCE values in both high-risk families are not significantly different from controls; (5) Neither the age nor sex of the individual affects SCE frequency; and (6) The observed distribution of exchanges agrees with that expected based on the proportion of the genome represented by each chromosome group. |
doi_str_mv | 10.1016/0165-4608(83)90013-4 |
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Controls consisted of spouses who married into the high-risk kindreds, hospital personnel, and others (primarily tradesmen without history of occupational exposure). Results show that: (1) Women with active breast cancer have a significantly higher mean SCE frequency than control women or women greater than 5 yr posttreatment for breast cancer; (2) Cigarette smokers show a significantly higher number of SCEs than was observed in nonsmokers; (3) The increase in SCE level in smokers is dose-related to exposure as measured by cumulative pack-years; (4) SCE values in both high-risk families are not significantly different from controls; (5) Neither the age nor sex of the individual affects SCE frequency; and (6) The observed distribution of exchanges agrees with that expected based on the proportion of the genome represented by each chromosome group.</description><identifier>ISSN: 0165-4608</identifier><identifier>EISSN: 1873-4456</identifier><identifier>DOI: 10.1016/0165-4608(83)90013-4</identifier><identifier>PMID: 6861118</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Age Factors ; Aged ; Breast Neoplasms - genetics ; Crossing Over, Genetic ; Female ; Humans ; Lymphocytes - ultrastructure ; Male ; Middle Aged ; Models, Biological ; Risk ; Sex Factors ; Sister Chromatid Exchange ; Smoking</subject><ispartof>Cancer genetics and cytogenetics, 1983-07, Vol.9 (3), p.289-299</ispartof><rights>1983</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-adb5d4fa75df287158843b752507d98d11a20ddc49b3e518ada703971d73e73e3</citedby><cites>FETCH-LOGICAL-c454t-adb5d4fa75df287158843b752507d98d11a20ddc49b3e518ada703971d73e73e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0165-4608(83)90013-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6861118$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Livingston, Gordon K.</creatorcontrib><creatorcontrib>Cannon, Lisa A.</creatorcontrib><creatorcontrib>Timothy Bishop, D.</creatorcontrib><creatorcontrib>Johnson, Penny</creatorcontrib><creatorcontrib>Fineman, Robert M.</creatorcontrib><title>Sister chromatid exchange: Variation by age, sex, smoking, and breast cancer status</title><title>Cancer genetics and cytogenetics</title><addtitle>Cancer Genet Cytogenet</addtitle><description>Variation in sister chromatid exchange (SCE) frequency in lymphocytes of 125 persons was compared using a multivariate general linear model. The study was performed to determine whether SCE frequency differs with respect to age, sex, smoking, and breast cancer status. Study subjects were divided into: members of two branches of families having an excess of cancer (primarily breast) including a brother and sister in one family who developed nonbreast malignancies within 1 yr of the study; women in both families successfully treated for breast cancer (all at least 5 yr posttreatment); and women from the general population with confirmed breast cancer.
Controls consisted of spouses who married into the high-risk kindreds, hospital personnel, and others (primarily tradesmen without history of occupational exposure). Results show that: (1) Women with active breast cancer have a significantly higher mean SCE frequency than control women or women greater than 5 yr posttreatment for breast cancer; (2) Cigarette smokers show a significantly higher number of SCEs than was observed in nonsmokers; (3) The increase in SCE level in smokers is dose-related to exposure as measured by cumulative pack-years; (4) SCE values in both high-risk families are not significantly different from controls; (5) Neither the age nor sex of the individual affects SCE frequency; and (6) The observed distribution of exchanges agrees with that expected based on the proportion of the genome represented by each chromosome group.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Breast Neoplasms - genetics</subject><subject>Crossing Over, Genetic</subject><subject>Female</subject><subject>Humans</subject><subject>Lymphocytes - ultrastructure</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Models, Biological</subject><subject>Risk</subject><subject>Sex Factors</subject><subject>Sister Chromatid Exchange</subject><subject>Smoking</subject><issn>0165-4608</issn><issn>1873-4456</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkFtLAzEQhYMoWi__QCFPotDVZJNssj4IUrxBwYeqryGbzNZod1eTrdh_b2qLjwpJJsyccwY-hA4pOaOEFufpiowXRJ0odloSQlnGN9CAKpk-XBSbaPAr2UG7Mb4SQmReFttou1AFpVQN0GTiYw8B25fQNab3DsOXfTHtFC7wswk-tboWVwtspjDEEb7S03Rvvp0OsWkdrgKY2GNrWptSYm_6edxHW7WZRThY1z30dHP9OLrLxg-396OrcWa54H1mXCUcr40Urs6VpEIpziopckGkK5Wj1OTEOcvLioGgyjgjCSsldZJBOmwPHa9y30P3MYfY68ZHC7OZaaGbR61Icgmp_hVSVnDFCpqEfCW0oYsxQK3fg29MWGhK9BK6XhLVS6JaMf0DXfNkO1rnz6sG3K9pTTnNL1dzSDQ-PQQdrYdEzPkAtteu838v-AaOcI-W</recordid><startdate>198307</startdate><enddate>198307</enddate><creator>Livingston, Gordon K.</creator><creator>Cannon, Lisa A.</creator><creator>Timothy Bishop, D.</creator><creator>Johnson, Penny</creator><creator>Fineman, Robert M.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>198307</creationdate><title>Sister chromatid exchange: Variation by age, sex, smoking, and breast cancer status</title><author>Livingston, Gordon K. ; Cannon, Lisa A. ; Timothy Bishop, D. ; Johnson, Penny ; Fineman, Robert M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-adb5d4fa75df287158843b752507d98d11a20ddc49b3e518ada703971d73e73e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Breast Neoplasms - genetics</topic><topic>Crossing Over, Genetic</topic><topic>Female</topic><topic>Humans</topic><topic>Lymphocytes - ultrastructure</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Models, Biological</topic><topic>Risk</topic><topic>Sex Factors</topic><topic>Sister Chromatid Exchange</topic><topic>Smoking</topic><toplevel>online_resources</toplevel><creatorcontrib>Livingston, Gordon K.</creatorcontrib><creatorcontrib>Cannon, Lisa A.</creatorcontrib><creatorcontrib>Timothy Bishop, D.</creatorcontrib><creatorcontrib>Johnson, Penny</creatorcontrib><creatorcontrib>Fineman, Robert M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer genetics and cytogenetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Livingston, Gordon K.</au><au>Cannon, Lisa A.</au><au>Timothy Bishop, D.</au><au>Johnson, Penny</au><au>Fineman, Robert M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sister chromatid exchange: Variation by age, sex, smoking, and breast cancer status</atitle><jtitle>Cancer genetics and cytogenetics</jtitle><addtitle>Cancer Genet Cytogenet</addtitle><date>1983-07</date><risdate>1983</risdate><volume>9</volume><issue>3</issue><spage>289</spage><epage>299</epage><pages>289-299</pages><issn>0165-4608</issn><eissn>1873-4456</eissn><abstract>Variation in sister chromatid exchange (SCE) frequency in lymphocytes of 125 persons was compared using a multivariate general linear model. The study was performed to determine whether SCE frequency differs with respect to age, sex, smoking, and breast cancer status. Study subjects were divided into: members of two branches of families having an excess of cancer (primarily breast) including a brother and sister in one family who developed nonbreast malignancies within 1 yr of the study; women in both families successfully treated for breast cancer (all at least 5 yr posttreatment); and women from the general population with confirmed breast cancer.
Controls consisted of spouses who married into the high-risk kindreds, hospital personnel, and others (primarily tradesmen without history of occupational exposure). Results show that: (1) Women with active breast cancer have a significantly higher mean SCE frequency than control women or women greater than 5 yr posttreatment for breast cancer; (2) Cigarette smokers show a significantly higher number of SCEs than was observed in nonsmokers; (3) The increase in SCE level in smokers is dose-related to exposure as measured by cumulative pack-years; (4) SCE values in both high-risk families are not significantly different from controls; (5) Neither the age nor sex of the individual affects SCE frequency; and (6) The observed distribution of exchanges agrees with that expected based on the proportion of the genome represented by each chromosome group.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>6861118</pmid><doi>10.1016/0165-4608(83)90013-4</doi><tpages>11</tpages></addata></record> |
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subjects | Adult Age Factors Aged Breast Neoplasms - genetics Crossing Over, Genetic Female Humans Lymphocytes - ultrastructure Male Middle Aged Models, Biological Risk Sex Factors Sister Chromatid Exchange Smoking |
title | Sister chromatid exchange: Variation by age, sex, smoking, and breast cancer status |
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