EPA in the Prevention of Restenosis Post PTCA
The effect of fish oil on restenosis was evaluated in patients undergoing coronary balloon angioplasty. In addition to routine pharmacotherapy, subjects were given 2.8 g of eicosapentanoic acid (EPA) daily. Treatment was started within twenty-four hours after successful percutaneous transluminal cor...
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| Veröffentlicht in: | Angiology 1991-03, Vol.42 (3), p.187-194 |
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| container_title | Angiology |
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| creator | Bowles, Mark Howard Klonis, Demo Plavac, Thomas G. Gonzales, Brenda Francisco, Dan A. Roberts, Roger W. Boxberger, Gregory R. Poliner, Larry R. Galichia, Joseph P. |
| description | The effect of fish oil on restenosis was evaluated in patients undergoing coronary balloon angioplasty. In addition to routine pharmacotherapy, subjects were given 2.8 g of eicosapentanoic acid (EPA) daily. Treatment was started within twenty-four hours after successful percutaneous transluminal coronary angioplasty (PTCA). After six months of therapy, participants were subjected to coronary arteriography, exercise scintigraphy, exercise electrocardiography, or clinical evaluation.
Follow-up evaluation involved 97 coronary lesions in 85 patients. Partial or significant restenosis occurred in 36.5% of patients and 33 % of vessels. The presence of severe stenosis before PTCA, dissection, thrombus, multilesion PTCA, and template bleeding time values were not correlated with restenosis. Dilation of the left anterior descending (LAD) and a residual stenosis≥ 35 % were associated with restenosis.
Approximately 20% of the patients related difficulty in taking the fish oil. Furthermore, these results show no advantage over expected restenosis rates. |
| doi_str_mv | 10.1177/000331979104200302 |
| format | Article |
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Follow-up evaluation involved 97 coronary lesions in 85 patients. Partial or significant restenosis occurred in 36.5% of patients and 33 % of vessels. The presence of severe stenosis before PTCA, dissection, thrombus, multilesion PTCA, and template bleeding time values were not correlated with restenosis. Dilation of the left anterior descending (LAD) and a residual stenosis≥ 35 % were associated with restenosis.
Approximately 20% of the patients related difficulty in taking the fish oil. Furthermore, these results show no advantage over expected restenosis rates.</description><identifier>ISSN: 0003-3197</identifier><identifier>EISSN: 1940-1574</identifier><identifier>DOI: 10.1177/000331979104200302</identifier><identifier>PMID: 2018239</identifier><identifier>CODEN: ANGIAB</identifier><language>eng</language><publisher>Thousand Oaks, CA: SAGE Publications</publisher><subject>Angioplasty, Balloon, Coronary ; Anticoagulants - therapeutic use ; Biological and medical sciences ; Constriction, Pathologic ; Coronary Angiography ; Coronary Disease - diagnostic imaging ; Coronary Disease - drug therapy ; Coronary Disease - pathology ; Coronary Disease - prevention & control ; Coronary Disease - therapy ; Coronary Vessels - pathology ; Eicosapentaenoic Acid - administration & dosage ; Eicosapentaenoic Acid - therapeutic use ; Exercise Test - drug effects ; Follow-Up Studies ; General and cellular metabolism. Vitamins ; Humans ; Medical sciences ; Pharmacology. Drug treatments</subject><ispartof>Angiology, 1991-03, Vol.42 (3), p.187-194</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c367t-9bdcf2b338dc356363714714e6f46b9a1e8ca41f74eee27ca6651faf83b794da3</citedby><cites>FETCH-LOGICAL-c367t-9bdcf2b338dc356363714714e6f46b9a1e8ca41f74eee27ca6651faf83b794da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/000331979104200302$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/000331979104200302$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5600652$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2018239$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bowles, Mark Howard</creatorcontrib><creatorcontrib>Klonis, Demo</creatorcontrib><creatorcontrib>Plavac, Thomas G.</creatorcontrib><creatorcontrib>Gonzales, Brenda</creatorcontrib><creatorcontrib>Francisco, Dan A.</creatorcontrib><creatorcontrib>Roberts, Roger W.</creatorcontrib><creatorcontrib>Boxberger, Gregory R.</creatorcontrib><creatorcontrib>Poliner, Larry R.</creatorcontrib><creatorcontrib>Galichia, Joseph P.</creatorcontrib><title>EPA in the Prevention of Restenosis Post PTCA</title><title>Angiology</title><addtitle>Angiology</addtitle><description>The effect of fish oil on restenosis was evaluated in patients undergoing coronary balloon angioplasty. In addition to routine pharmacotherapy, subjects were given 2.8 g of eicosapentanoic acid (EPA) daily. Treatment was started within twenty-four hours after successful percutaneous transluminal coronary angioplasty (PTCA). After six months of therapy, participants were subjected to coronary arteriography, exercise scintigraphy, exercise electrocardiography, or clinical evaluation.
Follow-up evaluation involved 97 coronary lesions in 85 patients. Partial or significant restenosis occurred in 36.5% of patients and 33 % of vessels. The presence of severe stenosis before PTCA, dissection, thrombus, multilesion PTCA, and template bleeding time values were not correlated with restenosis. Dilation of the left anterior descending (LAD) and a residual stenosis≥ 35 % were associated with restenosis.
Approximately 20% of the patients related difficulty in taking the fish oil. Furthermore, these results show no advantage over expected restenosis rates.</description><subject>Angioplasty, Balloon, Coronary</subject><subject>Anticoagulants - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Constriction, Pathologic</subject><subject>Coronary Angiography</subject><subject>Coronary Disease - diagnostic imaging</subject><subject>Coronary Disease - drug therapy</subject><subject>Coronary Disease - pathology</subject><subject>Coronary Disease - prevention & control</subject><subject>Coronary Disease - therapy</subject><subject>Coronary Vessels - pathology</subject><subject>Eicosapentaenoic Acid - administration & dosage</subject><subject>Eicosapentaenoic Acid - therapeutic use</subject><subject>Exercise Test - drug effects</subject><subject>Follow-Up Studies</subject><subject>General and cellular metabolism. Vitamins</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Pharmacology. 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Vitamins</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bowles, Mark Howard</creatorcontrib><creatorcontrib>Klonis, Demo</creatorcontrib><creatorcontrib>Plavac, Thomas G.</creatorcontrib><creatorcontrib>Gonzales, Brenda</creatorcontrib><creatorcontrib>Francisco, Dan A.</creatorcontrib><creatorcontrib>Roberts, Roger W.</creatorcontrib><creatorcontrib>Boxberger, Gregory R.</creatorcontrib><creatorcontrib>Poliner, Larry R.</creatorcontrib><creatorcontrib>Galichia, Joseph P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Angiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bowles, Mark Howard</au><au>Klonis, Demo</au><au>Plavac, Thomas G.</au><au>Gonzales, Brenda</au><au>Francisco, Dan A.</au><au>Roberts, Roger W.</au><au>Boxberger, Gregory R.</au><au>Poliner, Larry R.</au><au>Galichia, Joseph P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EPA in the Prevention of Restenosis Post PTCA</atitle><jtitle>Angiology</jtitle><addtitle>Angiology</addtitle><date>1991-03-01</date><risdate>1991</risdate><volume>42</volume><issue>3</issue><spage>187</spage><epage>194</epage><pages>187-194</pages><issn>0003-3197</issn><eissn>1940-1574</eissn><coden>ANGIAB</coden><abstract>The effect of fish oil on restenosis was evaluated in patients undergoing coronary balloon angioplasty. In addition to routine pharmacotherapy, subjects were given 2.8 g of eicosapentanoic acid (EPA) daily. Treatment was started within twenty-four hours after successful percutaneous transluminal coronary angioplasty (PTCA). After six months of therapy, participants were subjected to coronary arteriography, exercise scintigraphy, exercise electrocardiography, or clinical evaluation.
Follow-up evaluation involved 97 coronary lesions in 85 patients. Partial or significant restenosis occurred in 36.5% of patients and 33 % of vessels. The presence of severe stenosis before PTCA, dissection, thrombus, multilesion PTCA, and template bleeding time values were not correlated with restenosis. Dilation of the left anterior descending (LAD) and a residual stenosis≥ 35 % were associated with restenosis.
Approximately 20% of the patients related difficulty in taking the fish oil. Furthermore, these results show no advantage over expected restenosis rates.</abstract><cop>Thousand Oaks, CA</cop><pub>SAGE Publications</pub><pmid>2018239</pmid><doi>10.1177/000331979104200302</doi><tpages>8</tpages></addata></record> |
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| ispartof | Angiology, 1991-03, Vol.42 (3), p.187-194 |
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| language | eng |
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| source | MEDLINE; SAGE Complete |
| subjects | Angioplasty, Balloon, Coronary Anticoagulants - therapeutic use Biological and medical sciences Constriction, Pathologic Coronary Angiography Coronary Disease - diagnostic imaging Coronary Disease - drug therapy Coronary Disease - pathology Coronary Disease - prevention & control Coronary Disease - therapy Coronary Vessels - pathology Eicosapentaenoic Acid - administration & dosage Eicosapentaenoic Acid - therapeutic use Exercise Test - drug effects Follow-Up Studies General and cellular metabolism. Vitamins Humans Medical sciences Pharmacology. Drug treatments |
| title | EPA in the Prevention of Restenosis Post PTCA |
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