Class III antiarrhythmic action of d-sotalol during hypothermia

To investigate whether changes in temperature influence the electrophysiologic effects of the class III antiarrhythmic agent d-sotalol, we studied its effects on propranolol-pretreated guinea pig papillary muscles at temperatures ranging from 37° to 27° C by means of conventional microelectrode tech...

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Veröffentlicht in:	The American heart journal 1991-05, Vol.121 (5), p.1429-1436
Hauptverfasser:	Bjørnstad, Hanne, Tande, Pȧl M., Refsum, Helge
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Animals Anti-Arrhythmia Agents Antiarythmic agents Biological and medical sciences Cardiovascular system Guinea Pigs Heart Conduction System - drug effects Heart Conduction System - physiology Hypothermia, Induced Medical sciences Membrane Potentials - drug effects Papillary Muscles - drug effects Pharmacology. Drug treatments Potassium Channels - drug effects Sotalol - pharmacology Stereoisomerism
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