A Randomized Study of Beef Lung and Pork Mucosal Heparin in Cardiac Surgery
Beef lung heparin had substantially greater anticoagulant activity than pork mucosal heparin during a preoperative heparin tolerance test and also during cardiopulmonary bypass (CFB) in 100 randomized patients. Supplemental heparin was needed during CPB in many more of the patients receiving pork mu...
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| Veröffentlicht in: | The Annals of thoracic surgery 1983-06, Vol.35 (6), p.615-620 |
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| container_issue | 6 |
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| container_title | The Annals of thoracic surgery |
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| creator | Fiser, William P. Read, Raymond C. Wright, F. Elvis Vecchio, Thomas J. |
| description | Beef lung heparin had substantially greater anticoagulant activity than pork mucosal heparin during a preoperative heparin tolerance test and also during cardiopulmonary bypass (CFB) in 100 randomized patients. Supplemental heparin was needed during CPB in many more of the patients receiving pork mucosal heparin. Heparin rebound was detected in 16 patients; this low incidence may result from a relatively high protamine: heparin ratio. There was notably less postoperative bleeding in those who received beef lung heparin. Platelet counts were not altered by either type of heparin. It is surprising that the preoperative tolerance curve only predicted heparin sensitivity during CPB in one-half of the patients. Blood activated coagulation time levels were increased markedly by hemodilution and further raised by hypothermia. These data demonstrate that beef lung heparin is better than pork mucosal heparin for CPB. |
| doi_str_mv | 10.1016/S0003-4975(10)61072-7 |
| format | Article |
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These data demonstrate that beef lung heparin is better than pork mucosal heparin for CPB.</description><identifier>ISSN: 0003-4975</identifier><identifier>EISSN: 1552-6259</identifier><identifier>DOI: 10.1016/S0003-4975(10)61072-7</identifier><identifier>PMID: 6344819</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Animals ; Cardiopulmonary Bypass - methods ; Cattle ; Clinical Trials as Topic ; Dose-Response Relationship, Drug ; Drug Tolerance ; Heparin - adverse effects ; Heparin - pharmacology ; Heparin Antagonists ; Humans ; Prospective Studies ; Protamines - pharmacology ; Random Allocation ; Swine</subject><ispartof>The Annals of thoracic surgery, 1983-06, Vol.35 (6), p.615-620</ispartof><rights>1983 The Society of Thoracic Surgeons</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-23e4ab9555591fae7d9f784daa5dddac6f651aa5eb0dbf76e26ffba2f16cae923</citedby><cites>FETCH-LOGICAL-c442t-23e4ab9555591fae7d9f784daa5dddac6f651aa5eb0dbf76e26ffba2f16cae923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6344819$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fiser, William P.</creatorcontrib><creatorcontrib>Read, Raymond C.</creatorcontrib><creatorcontrib>Wright, F. Elvis</creatorcontrib><creatorcontrib>Vecchio, Thomas J.</creatorcontrib><title>A Randomized Study of Beef Lung and Pork Mucosal Heparin in Cardiac Surgery</title><title>The Annals of thoracic surgery</title><addtitle>Ann Thorac Surg</addtitle><description>Beef lung heparin had substantially greater anticoagulant activity than pork mucosal heparin during a preoperative heparin tolerance test and also during cardiopulmonary bypass (CFB) in 100 randomized patients. Supplemental heparin was needed during CPB in many more of the patients receiving pork mucosal heparin. Heparin rebound was detected in 16 patients; this low incidence may result from a relatively high protamine: heparin ratio. There was notably less postoperative bleeding in those who received beef lung heparin. Platelet counts were not altered by either type of heparin. It is surprising that the preoperative tolerance curve only predicted heparin sensitivity during CPB in one-half of the patients. Blood activated coagulation time levels were increased markedly by hemodilution and further raised by hypothermia. These data demonstrate that beef lung heparin is better than pork mucosal heparin for CPB.</description><subject>Animals</subject><subject>Cardiopulmonary Bypass - methods</subject><subject>Cattle</subject><subject>Clinical Trials as Topic</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Tolerance</subject><subject>Heparin - adverse effects</subject><subject>Heparin - pharmacology</subject><subject>Heparin Antagonists</subject><subject>Humans</subject><subject>Prospective Studies</subject><subject>Protamines - pharmacology</subject><subject>Random Allocation</subject><subject>Swine</subject><issn>0003-4975</issn><issn>1552-6259</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE9LAzEQxYMotVY_QiEn0cNqkt1kuyepRa1YUayeQzaZlGi7W5NdoX560z_0agiEyXtvhvkh1KfkihIqrqeEkDTJipxfUHIpKMlZkh-gLuWcJYLx4hB195ZjdBLCZyxZlDuoI9IsG9Cii56G-E1Vpl64XzB42rRmhWuLbwEsnrTVDEcRv9b-Cz-3ug5qjsewVN5VON6R8sYpjaetn4FfnaIjq-YBznZvD33c372Pxsnk5eFxNJwkOstYk7AUMlUWPJ6CWgW5KWw-yIxS3BijtLCC01hASUxpcwFMWFsqZqnQCgqW9tD5tu_S198thEYuXNAwn6sK6jbIAeGU05RHI98ata9D8GDl0ruF8itJiVxDlBuIck1o_bWBKPOY6-8GtOUCzD61oxb1m60OccsfB14G7aDSYJwH3UhTu38m_AEGMIEz</recordid><startdate>198306</startdate><enddate>198306</enddate><creator>Fiser, William P.</creator><creator>Read, Raymond C.</creator><creator>Wright, F. 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Elvis</creatorcontrib><creatorcontrib>Vecchio, Thomas J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Annals of thoracic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fiser, William P.</au><au>Read, Raymond C.</au><au>Wright, F. Elvis</au><au>Vecchio, Thomas J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Randomized Study of Beef Lung and Pork Mucosal Heparin in Cardiac Surgery</atitle><jtitle>The Annals of thoracic surgery</jtitle><addtitle>Ann Thorac Surg</addtitle><date>1983-06</date><risdate>1983</risdate><volume>35</volume><issue>6</issue><spage>615</spage><epage>620</epage><pages>615-620</pages><issn>0003-4975</issn><eissn>1552-6259</eissn><abstract>Beef lung heparin had substantially greater anticoagulant activity than pork mucosal heparin during a preoperative heparin tolerance test and also during cardiopulmonary bypass (CFB) in 100 randomized patients. Supplemental heparin was needed during CPB in many more of the patients receiving pork mucosal heparin. Heparin rebound was detected in 16 patients; this low incidence may result from a relatively high protamine: heparin ratio. There was notably less postoperative bleeding in those who received beef lung heparin. Platelet counts were not altered by either type of heparin. It is surprising that the preoperative tolerance curve only predicted heparin sensitivity during CPB in one-half of the patients. Blood activated coagulation time levels were increased markedly by hemodilution and further raised by hypothermia. These data demonstrate that beef lung heparin is better than pork mucosal heparin for CPB.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>6344819</pmid><doi>10.1016/S0003-4975(10)61072-7</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Annals of thoracic surgery, 1983-06, Vol.35 (6), p.615-620 |
| issn | 0003-4975 1552-6259 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals Cardiopulmonary Bypass - methods Cattle Clinical Trials as Topic Dose-Response Relationship, Drug Drug Tolerance Heparin - adverse effects Heparin - pharmacology Heparin Antagonists Humans Prospective Studies Protamines - pharmacology Random Allocation Swine |
| title | A Randomized Study of Beef Lung and Pork Mucosal Heparin in Cardiac Surgery |
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