Odorant-evoked potassium changes in the frog olfactory epithelium
Electroolfactogram (EOG) and extracellular potassium activity (aK) measurements were carried out in frog olfactory epithelia in vivo. Odorant-evoked changes in aK were characterized on the basis of depth profile analysis. Following an olfactory stimulation with butanol vapours, an increase in aK was...
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| Veröffentlicht in: | Brain research 1991-01, Vol.539 (1), p.1-5 |
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| creator | Khayari, Abdelmajid Math, François Trotier, Didier |
| description | Electroolfactogram (EOG) and extracellular potassium activity (aK) measurements were carried out in frog olfactory epithelia in vivo. Odorant-evoked changes in aK were characterized on the basis of depth profile analysis. Following an olfactory stimulation with butanol vapours, an increase in aK was measured in the mucus and the proximal part of the epithelium; this response started after the beginning of the EOG and was proportional to the amplitude of the latter. In the deeper part of the epithelium, the aK response had complex waveforms showing an initial K decrease which was suppressed by local application of ouabain, suggesting the existence of a pumping mechanism at this level. The results are discussed in terms of extracellular accumulation of K ions following neuroreceptor activation with respect to EOG generation theories. |
| doi_str_mv | 10.1016/0006-8993(91)90679-P |
| format | Article |
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Odorant-evoked changes in aK were characterized on the basis of depth profile analysis. Following an olfactory stimulation with butanol vapours, an increase in aK was measured in the mucus and the proximal part of the epithelium; this response started after the beginning of the EOG and was proportional to the amplitude of the latter. In the deeper part of the epithelium, the aK response had complex waveforms showing an initial K decrease which was suppressed by local application of ouabain, suggesting the existence of a pumping mechanism at this level. The results are discussed in terms of extracellular accumulation of K ions following neuroreceptor activation with respect to EOG generation theories.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(91)90679-P</identifier><identifier>PMID: 2015495</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Animals ; Anura ; Biological and medical sciences ; Butanols - pharmacology ; Cobalt - pharmacology ; Electric Stimulation ; Electrophysiology - methods ; Epithelium - drug effects ; Epithelium - physiology ; Freshwater ; Frog ; Fundamental and applied biological sciences. Psychology ; Ion-selective microelectrode ; Odorants ; Olfactory epithelium ; Olfactory Mucosa - physiology ; Olfactory system and olfaction. Gustatory system and gustation ; Ouabain - pharmacology ; Potassium ; Potassium - pharmacology ; Potassium - physiology ; Ranidae ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research, 1991-01, Vol.539 (1), p.1-5</ispartof><rights>1991 Elsevier Science Publishers B.V. 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Odorant-evoked changes in aK were characterized on the basis of depth profile analysis. Following an olfactory stimulation with butanol vapours, an increase in aK was measured in the mucus and the proximal part of the epithelium; this response started after the beginning of the EOG and was proportional to the amplitude of the latter. In the deeper part of the epithelium, the aK response had complex waveforms showing an initial K decrease which was suppressed by local application of ouabain, suggesting the existence of a pumping mechanism at this level. The results are discussed in terms of extracellular accumulation of K ions following neuroreceptor activation with respect to EOG generation theories.</description><subject>Animals</subject><subject>Anura</subject><subject>Biological and medical sciences</subject><subject>Butanols - pharmacology</subject><subject>Cobalt - pharmacology</subject><subject>Electric Stimulation</subject><subject>Electrophysiology - methods</subject><subject>Epithelium - drug effects</subject><subject>Epithelium - physiology</subject><subject>Freshwater</subject><subject>Frog</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ion-selective microelectrode</subject><subject>Odorants</subject><subject>Olfactory epithelium</subject><subject>Olfactory Mucosa - physiology</subject><subject>Olfactory system and olfaction. Gustatory system and gustation</subject><subject>Ouabain - pharmacology</subject><subject>Potassium</subject><subject>Potassium - pharmacology</subject><subject>Potassium - physiology</subject><subject>Ranidae</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMotX78A4W9KHpYTXaTTeYiFPELBHvQc0izszW63dRkK_jvTW2pNz0NM_PMy_AQcsToBaOsuqSUVrkCKM-AnQOtJOTjLTJkShZ5VXC6TYYbZJfsxfiW2rIEOiCDgjLBQQzJ6Kn2wXR9jp_-Hets7nsTo1vMMvtquinGzHVZ_4pZE_w0821jbO_DV4Zzl6ZtAg_ITmPaiIfruk9ebm-er-_zx6e7h-vRY245U31urJRIrayVYCUgNLxUlnEorRWCKeBGAK8mQkoKrJmImttqIo2pBRTSSCj3yekqdx78xwJjr2cuWmxb06FfRK2oYFwV5b8gEwCKK5FAvgJt8DEGbPQ8uJkJX5pRvVSsl_700p8Gpn8U63E6O17nLyYzrDdHa6dpf7Lem2hN2yS91sXfbOBQVLJI3NWKw2Tt02HQ0TrsLNYuoO117d3fj3wDTHCXHQ</recordid><startdate>19910118</startdate><enddate>19910118</enddate><creator>Khayari, Abdelmajid</creator><creator>Math, François</creator><creator>Trotier, Didier</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>F1W</scope><scope>FR3</scope><scope>H95</scope><scope>L.G</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19910118</creationdate><title>Odorant-evoked potassium changes in the frog olfactory epithelium</title><author>Khayari, Abdelmajid ; Math, François ; Trotier, Didier</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-ac77e0c7d85139e9f438c1493cc551894a5946b577091fb5d4c6b7aad5927a793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Animals</topic><topic>Anura</topic><topic>Biological and medical sciences</topic><topic>Butanols - pharmacology</topic><topic>Cobalt - pharmacology</topic><topic>Electric Stimulation</topic><topic>Electrophysiology - methods</topic><topic>Epithelium - drug effects</topic><topic>Epithelium - physiology</topic><topic>Freshwater</topic><topic>Frog</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Ion-selective microelectrode</topic><topic>Odorants</topic><topic>Olfactory epithelium</topic><topic>Olfactory Mucosa - physiology</topic><topic>Olfactory system and olfaction. Gustatory system and gustation</topic><topic>Ouabain - pharmacology</topic><topic>Potassium</topic><topic>Potassium - pharmacology</topic><topic>Potassium - physiology</topic><topic>Ranidae</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khayari, Abdelmajid</creatorcontrib><creatorcontrib>Math, François</creatorcontrib><creatorcontrib>Trotier, Didier</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khayari, Abdelmajid</au><au>Math, François</au><au>Trotier, Didier</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Odorant-evoked potassium changes in the frog olfactory epithelium</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1991-01-18</date><risdate>1991</risdate><volume>539</volume><issue>1</issue><spage>1</spage><epage>5</epage><pages>1-5</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Electroolfactogram (EOG) and extracellular potassium activity (aK) measurements were carried out in frog olfactory epithelia in vivo. Odorant-evoked changes in aK were characterized on the basis of depth profile analysis. Following an olfactory stimulation with butanol vapours, an increase in aK was measured in the mucus and the proximal part of the epithelium; this response started after the beginning of the EOG and was proportional to the amplitude of the latter. In the deeper part of the epithelium, the aK response had complex waveforms showing an initial K decrease which was suppressed by local application of ouabain, suggesting the existence of a pumping mechanism at this level. The results are discussed in terms of extracellular accumulation of K ions following neuroreceptor activation with respect to EOG generation theories.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>2015495</pmid><doi>10.1016/0006-8993(91)90679-P</doi><tpages>5</tpages></addata></record> |
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| subjects | Animals Anura Biological and medical sciences Butanols - pharmacology Cobalt - pharmacology Electric Stimulation Electrophysiology - methods Epithelium - drug effects Epithelium - physiology Freshwater Frog Fundamental and applied biological sciences. Psychology Ion-selective microelectrode Odorants Olfactory epithelium Olfactory Mucosa - physiology Olfactory system and olfaction. Gustatory system and gustation Ouabain - pharmacology Potassium Potassium - pharmacology Potassium - physiology Ranidae Vertebrates: nervous system and sense organs |
| title | Odorant-evoked potassium changes in the frog olfactory epithelium |
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