Biosynthesis and post-translational modification of CD6, a T cell signal-transducing molecule

CD6 (T12) is a 130-kDa glycoprotein present on the surface of human T cells. Previously, we demonstrated that the anti-T12 and anti-2H1 monoclonal antibodies recognized different epitopes on CD6, and both were capable of transducing activation signals to T cells. Anti-T12 augmented suboptimal signal...

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Veröffentlicht in:	The Journal of biological chemistry 1991-04, Vol.266 (11), p.7137-7143
Hauptverfasser:	Swack, J A, Mier, J W, Romain, P L, Hull, S R, Rudd, C E
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal Antigens, CD - biosynthesis Antigens, Differentiation, T-Lymphocyte - biosynthesis Antigens, Differentiation, T-Lymphocyte - genetics Antigens, Differentiation, T-Lymphocyte - isolation & purification Biological and medical sciences Cell physiology Fundamental and applied biological sciences. Psychology Humans Kinetics Membrane Glycoproteins - biosynthesis Molecular and cellular biology Molecular Weight Protein Processing, Post-Translational Receptors, Interleukin-2 - biosynthesis Signal Transduction T-Lymphocytes - immunology T-Lymphocytes - physiology Tunicamycin - pharmacology
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