Co-expression of vimentin and cytokeratins in parietal endoderm cells of early mouse embryo
Of the five classes of intermediate filaments found in vertebrate tissues, the cytokeratins are considered unique to epithelial tissues, while vimentin is expressed by endothelial and mesenchymal cells 1 . In neither case is the precise function of the filament system known. Epithelial cells in cult...
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| Veröffentlicht in: | Nature (London) 1983-06, Vol.303 (5919), p.701-704 |
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| creator | Lane, E. B. Hogan, B. L. M. Kurkinen, M. Garrels, J. I. |
| description | Of the five classes of intermediate filaments found in vertebrate tissues, the cytokeratins are considered unique to epithelial tissues, while vimentin is expressed by endothelial and mesenchymal cells
1
. In neither case is the precise function of the filament system known. Epithelial cells in culture often express vimentin as well as cytokeratins
1–3
, but co-expression
in vivo
, as reported for pleomorphic adenomas of the parotid gland
4,5
and metastatic carcinoma cells in ascites or pleural fluid
6
, is still controversial. Here we report the co-expression of cytokeratins and vimentin
in situ
, in the parietal endoderm of the mouse embryo 8.5–13.5 days old. This population of individual, motile cells seems to be derived from a conventional epithelium by migration and differentiation. Our results support the idea that vimentin expression is specifically related to reduced cell-to-cell contact, and to the independent existence of a cell following detachment from an epithelial sheet. |
| doi_str_mv | 10.1038/303701a0 |
| format | Article |
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1
. In neither case is the precise function of the filament system known. Epithelial cells in culture often express vimentin as well as cytokeratins
1–3
, but co-expression
in vivo
, as reported for pleomorphic adenomas of the parotid gland
4,5
and metastatic carcinoma cells in ascites or pleural fluid
6
, is still controversial. Here we report the co-expression of cytokeratins and vimentin
in situ
, in the parietal endoderm of the mouse embryo 8.5–13.5 days old. This population of individual, motile cells seems to be derived from a conventional epithelium by migration and differentiation. Our results support the idea that vimentin expression is specifically related to reduced cell-to-cell contact, and to the independent existence of a cell following detachment from an epithelial sheet.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/303701a0</identifier><identifier>PMID: 6190091</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Blastocyst - metabolism ; cytokeratin ; Embryo, Mammalian - metabolism ; embryos ; Endoderm - metabolism ; Endoderm - ultrastructure ; epithelium ; Female ; Fluorescent Antibody Technique ; Humanities and Social Sciences ; Intermediate Filament Proteins - genetics ; Intermediate Filament Proteins - isolation & purification ; Keratins - genetics ; Keratins - isolation & purification ; letter ; Mice ; Mice, Inbred Strains ; Microscopy, Electron, Scanning ; Molecular Weight ; multidisciplinary ; Pregnancy ; Science ; Vimentin</subject><ispartof>Nature (London), 1983-06, Vol.303 (5919), p.701-704</ispartof><rights>Springer Nature Limited 1983</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-bb32dcc1cc069d1325e65c97ced076854982db56c49ead4f2d844e93b60d315f3</citedby><cites>FETCH-LOGICAL-c409t-bb32dcc1cc069d1325e65c97ced076854982db56c49ead4f2d844e93b60d315f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/303701a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/303701a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6190091$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lane, E. B.</creatorcontrib><creatorcontrib>Hogan, B. L. M.</creatorcontrib><creatorcontrib>Kurkinen, M.</creatorcontrib><creatorcontrib>Garrels, J. I.</creatorcontrib><title>Co-expression of vimentin and cytokeratins in parietal endoderm cells of early mouse embryo</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>Of the five classes of intermediate filaments found in vertebrate tissues, the cytokeratins are considered unique to epithelial tissues, while vimentin is expressed by endothelial and mesenchymal cells
1
. In neither case is the precise function of the filament system known. Epithelial cells in culture often express vimentin as well as cytokeratins
1–3
, but co-expression
in vivo
, as reported for pleomorphic adenomas of the parotid gland
4,5
and metastatic carcinoma cells in ascites or pleural fluid
6
, is still controversial. Here we report the co-expression of cytokeratins and vimentin
in situ
, in the parietal endoderm of the mouse embryo 8.5–13.5 days old. This population of individual, motile cells seems to be derived from a conventional epithelium by migration and differentiation. Our results support the idea that vimentin expression is specifically related to reduced cell-to-cell contact, and to the independent existence of a cell following detachment from an epithelial sheet.</description><subject>Animals</subject><subject>Blastocyst - metabolism</subject><subject>cytokeratin</subject><subject>Embryo, Mammalian - metabolism</subject><subject>embryos</subject><subject>Endoderm - metabolism</subject><subject>Endoderm - ultrastructure</subject><subject>epithelium</subject><subject>Female</subject><subject>Fluorescent Antibody Technique</subject><subject>Humanities and Social Sciences</subject><subject>Intermediate Filament Proteins - genetics</subject><subject>Intermediate Filament Proteins - isolation & purification</subject><subject>Keratins - genetics</subject><subject>Keratins - isolation & purification</subject><subject>letter</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Microscopy, Electron, Scanning</subject><subject>Molecular Weight</subject><subject>multidisciplinary</subject><subject>Pregnancy</subject><subject>Science</subject><subject>Vimentin</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE9LxDAQxYMo67oKfgEhJ9FDddKkaXKUxX-w4EVPHkqaTKVr26xJV-y3t8uuXjx4Gmbebx6PR8gpgysGXF1z4DkwA3tkykQuEyFVvk-mAKlKQHF5SI5iXAJAxnIxIRPJNIBmU_I69wl-rQLGWPuO-op-1i12fd1R0zlqh96_YzDjHul4W5lQY28aip3zDkNLLTZN3PyhCc1AW7-OSLEtw-CPyUFlmognuzkjL3e3z_OHZPF0_zi_WSRWgO6TsuSps5ZZC1I7xtMMZWZ1btFBLlUmtEpdmUkrNBonqtQpIVDzUoLjLKv4jJxvfVfBf6wx9kVbx00u0-EYp1CQQa6F_hdkXOVK6A14sQVt8DEGrIpVqFsThoJBsSm8-Cl8RM92nuuyRfcL7hoe9cutHkele8NQLP06dGMff72-AZfuiHQ</recordid><startdate>19830601</startdate><enddate>19830601</enddate><creator>Lane, E. B.</creator><creator>Hogan, B. L. M.</creator><creator>Kurkinen, M.</creator><creator>Garrels, J. I.</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19830601</creationdate><title>Co-expression of vimentin and cytokeratins in parietal endoderm cells of early mouse embryo</title><author>Lane, E. B. ; Hogan, B. L. M. ; Kurkinen, M. ; Garrels, J. I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-bb32dcc1cc069d1325e65c97ced076854982db56c49ead4f2d844e93b60d315f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Animals</topic><topic>Blastocyst - metabolism</topic><topic>cytokeratin</topic><topic>Embryo, Mammalian - metabolism</topic><topic>embryos</topic><topic>Endoderm - metabolism</topic><topic>Endoderm - ultrastructure</topic><topic>epithelium</topic><topic>Female</topic><topic>Fluorescent Antibody Technique</topic><topic>Humanities and Social Sciences</topic><topic>Intermediate Filament Proteins - genetics</topic><topic>Intermediate Filament Proteins - isolation & purification</topic><topic>Keratins - genetics</topic><topic>Keratins - isolation & purification</topic><topic>letter</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Microscopy, Electron, Scanning</topic><topic>Molecular Weight</topic><topic>multidisciplinary</topic><topic>Pregnancy</topic><topic>Science</topic><topic>Vimentin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lane, E. B.</creatorcontrib><creatorcontrib>Hogan, B. L. M.</creatorcontrib><creatorcontrib>Kurkinen, M.</creatorcontrib><creatorcontrib>Garrels, J. I.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lane, E. B.</au><au>Hogan, B. L. M.</au><au>Kurkinen, M.</au><au>Garrels, J. 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1
. In neither case is the precise function of the filament system known. Epithelial cells in culture often express vimentin as well as cytokeratins
1–3
, but co-expression
in vivo
, as reported for pleomorphic adenomas of the parotid gland
4,5
and metastatic carcinoma cells in ascites or pleural fluid
6
, is still controversial. Here we report the co-expression of cytokeratins and vimentin
in situ
, in the parietal endoderm of the mouse embryo 8.5–13.5 days old. This population of individual, motile cells seems to be derived from a conventional epithelium by migration and differentiation. Our results support the idea that vimentin expression is specifically related to reduced cell-to-cell contact, and to the independent existence of a cell following detachment from an epithelial sheet.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>6190091</pmid><doi>10.1038/303701a0</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1983-06, Vol.303 (5919), p.701-704 |
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| language | eng |
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| subjects | Animals Blastocyst - metabolism cytokeratin Embryo, Mammalian - metabolism embryos Endoderm - metabolism Endoderm - ultrastructure epithelium Female Fluorescent Antibody Technique Humanities and Social Sciences Intermediate Filament Proteins - genetics Intermediate Filament Proteins - isolation & purification Keratins - genetics Keratins - isolation & purification letter Mice Mice, Inbred Strains Microscopy, Electron, Scanning Molecular Weight multidisciplinary Pregnancy Science Vimentin |
| title | Co-expression of vimentin and cytokeratins in parietal endoderm cells of early mouse embryo |
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