Complementation Between Sindbis Viral RNAs Produces Infectious Particles with a Bipartite Genome

Sindbis virus, the type member of the alpha-viruses, is an enveloped virus containing a nonsegmented positive-strand RNA genome. We show that the nonstructural and the structural genes can function to produce infectious virus particles when they are expressed on two different RNA segments. The nonst...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1991-04, Vol.88 (8), p.3253-3257
Hauptverfasser:	Geigenmuller-Gnirke, Ute, Weiss, Barbara, Wright, Rebecca, Schlesinger, Sondra
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cells, Cultured Chick Embryo Complementary DNA Embryos Fibroblasts Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Genes Genes, Viral Genetic Complementation Test Genetic Engineering Genetics Genomes Genomics Microbiology Morphogenesis Nucleic Acid Hybridization Recombination, Genetic RNA RNA, Messenger - genetics RNA, Viral - genetics Sindbis Virus Sindbis Virus - genetics Transcription, Genetic Transfection Viral RNA Viral Structural Proteins - genetics Virology Virus Replication Viruses
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