Glycine immunoreactive projections from the dorsal to the anteroventral cochlear nucleus
The aim of the present study was to investigate whether projections from the dorsal cochlear nucleus (DCN) to the anteroventral cochlear nucleus (AVCN) use either of two inhibitory transmitters, glycine or GABA. Retrograde HRP labeling of DCN-to-AVCN projection neurons was combined with postembeddin...
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| Veröffentlicht in: | Hearing research 1991, Vol.51 (1), p.11-28 |
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| creator | Saint Marie, Richard L Benson, Christina G Ostapoff, E.-Michael Morest, D.Kent |
| description | The aim of the present study was to investigate whether projections from the dorsal cochlear nucleus (DCN) to the anteroventral cochlear nucleus (AVCN) use either of two inhibitory transmitters, glycine or GABA. Retrograde HRP labeling of DCN-to-AVCN projection neurons was combined with postembedding immunocytochemistry in the DCN of guinea pigs. Following injections of HRP in the anterior or posterior divisions of AVCN, large numbers of neurons were labeled in the DCN. All of these were located in the deep layer, except for a few granule cells. Nearly all (96%) of the projection neurons were immunoreactive for glycine and most had dendritic and somatic morphologies corresponding to those of elongate neurons (so-called ‘corn’ cells); only a few resembled small stellate neurons. Few (3%) retrogradely labeled neurons were immunoreactive for GABA. The results suggest that projections from the deep DCN to the AVCN are formed primarily by glycinergic elongate neurons. These projections could have a substantial inhibitory influence on the output of neurons in the AVCN. |
| doi_str_mv | 10.1016/0378-5955(91)90003-R |
| format | Article |
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Retrograde HRP labeling of DCN-to-AVCN projection neurons was combined with postembedding immunocytochemistry in the DCN of guinea pigs. Following injections of HRP in the anterior or posterior divisions of AVCN, large numbers of neurons were labeled in the DCN. All of these were located in the deep layer, except for a few granule cells. Nearly all (96%) of the projection neurons were immunoreactive for glycine and most had dendritic and somatic morphologies corresponding to those of elongate neurons (so-called ‘corn’ cells); only a few resembled small stellate neurons. Few (3%) retrogradely labeled neurons were immunoreactive for GABA. The results suggest that projections from the deep DCN to the AVCN are formed primarily by glycinergic elongate neurons. These projections could have a substantial inhibitory influence on the output of neurons in the AVCN.</description><identifier>ISSN: 0378-5955</identifier><identifier>EISSN: 1878-5891</identifier><identifier>DOI: 10.1016/0378-5955(91)90003-R</identifier><identifier>PMID: 1672865</identifier><identifier>CODEN: HERED3</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Auditory pathways ; Auditory Pathways - anatomy & histology ; Auditory Pathways - physiology ; Biological and medical sciences ; Cochlea - innervation ; Cochlea - physiology ; Cochlear nucleus ; Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation ; Female ; Fundamental and applied biological sciences. Psychology ; GABA ; gamma-Aminobutyric Acid - physiology ; Glycine ; Glycine - physiology ; Guinea pig ; Guinea Pigs ; Horseradish peroxidase ; Immunocytochemistry ; Immunohistochemistry ; Male ; Neurotransmitter Agents - physiology ; Vertebrates: nervous system and sense organs</subject><ispartof>Hearing research, 1991, Vol.51 (1), p.11-28</ispartof><rights>1991</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-82d055a07691a8fd120aca6bff4461ff755cd014ea3299948c8fd7a765d01da53</citedby><cites>FETCH-LOGICAL-c438t-82d055a07691a8fd120aca6bff4461ff755cd014ea3299948c8fd7a765d01da53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/037859559190003R$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,4009,27902,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19713523$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1672865$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saint Marie, Richard L</creatorcontrib><creatorcontrib>Benson, Christina G</creatorcontrib><creatorcontrib>Ostapoff, E.-Michael</creatorcontrib><creatorcontrib>Morest, D.Kent</creatorcontrib><title>Glycine immunoreactive projections from the dorsal to the anteroventral cochlear nucleus</title><title>Hearing research</title><addtitle>Hear Res</addtitle><description>The aim of the present study was to investigate whether projections from the dorsal cochlear nucleus (DCN) to the anteroventral cochlear nucleus (AVCN) use either of two inhibitory transmitters, glycine or GABA. Retrograde HRP labeling of DCN-to-AVCN projection neurons was combined with postembedding immunocytochemistry in the DCN of guinea pigs. Following injections of HRP in the anterior or posterior divisions of AVCN, large numbers of neurons were labeled in the DCN. All of these were located in the deep layer, except for a few granule cells. Nearly all (96%) of the projection neurons were immunoreactive for glycine and most had dendritic and somatic morphologies corresponding to those of elongate neurons (so-called ‘corn’ cells); only a few resembled small stellate neurons. Few (3%) retrogradely labeled neurons were immunoreactive for GABA. The results suggest that projections from the deep DCN to the AVCN are formed primarily by glycinergic elongate neurons. These projections could have a substantial inhibitory influence on the output of neurons in the AVCN.</description><subject>Animals</subject><subject>Auditory pathways</subject><subject>Auditory Pathways - anatomy & histology</subject><subject>Auditory Pathways - physiology</subject><subject>Biological and medical sciences</subject><subject>Cochlea - innervation</subject><subject>Cochlea - physiology</subject><subject>Cochlear nucleus</subject><subject>Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GABA</subject><subject>gamma-Aminobutyric Acid - physiology</subject><subject>Glycine</subject><subject>Glycine - physiology</subject><subject>Guinea pig</subject><subject>Guinea Pigs</subject><subject>Horseradish peroxidase</subject><subject>Immunocytochemistry</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Neurotransmitter Agents - physiology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0378-5955</issn><issn>1878-5891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFLHTEQx4Mo-mr9Bi3sxdIets1sNrvJRSjSqiAIUsFbGLMTjOwmmuw-8Ns3z_eot54y-c9vhuHH2Cfg34FD94OLXtVSS_lVwzfNORf17R5bgdrESsM-W_1DjtiHnJ84Byna5pAdQtc3qpMrdn8xvlofqPLTtISYCO3s11Q9p_hEpYwhVy7FqZofqRpiyjhWc3z7YZgpxTWFOZXQRvs4EqYqLHakJX9kBw7HTCe795jd_f715_yyvr65uDr_eV3bVqi5Vs3ApUTedxpQuQEajha7B-fatgPneintwKElFI3WulW2QD32nSzpgFIcsy_bveXil4XybCafLY0jBopLNopL3gmAArZb0KaYcyJnnpOfML0a4GYj1GxsmY0to8G8CTW3Zezzbv_yMNHwPrQ1WPqnuz5mi6NLGKzP75juQchGFO5sy1GRsfaUTLaegqXBpyLaDNH__5C_GYeTVg</recordid><startdate>1991</startdate><enddate>1991</enddate><creator>Saint Marie, Richard L</creator><creator>Benson, Christina G</creator><creator>Ostapoff, E.-Michael</creator><creator>Morest, D.Kent</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>1991</creationdate><title>Glycine immunoreactive projections from the dorsal to the anteroventral cochlear nucleus</title><author>Saint Marie, Richard L ; Benson, Christina G ; Ostapoff, E.-Michael ; Morest, D.Kent</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-82d055a07691a8fd120aca6bff4461ff755cd014ea3299948c8fd7a765d01da53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Animals</topic><topic>Auditory pathways</topic><topic>Auditory Pathways - anatomy & histology</topic><topic>Auditory Pathways - physiology</topic><topic>Biological and medical sciences</topic><topic>Cochlea - innervation</topic><topic>Cochlea - physiology</topic><topic>Cochlear nucleus</topic><topic>Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GABA</topic><topic>gamma-Aminobutyric Acid - physiology</topic><topic>Glycine</topic><topic>Glycine - physiology</topic><topic>Guinea pig</topic><topic>Guinea Pigs</topic><topic>Horseradish peroxidase</topic><topic>Immunocytochemistry</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Neurotransmitter Agents - physiology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saint Marie, Richard L</creatorcontrib><creatorcontrib>Benson, Christina G</creatorcontrib><creatorcontrib>Ostapoff, E.-Michael</creatorcontrib><creatorcontrib>Morest, D.Kent</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Hearing research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saint Marie, Richard L</au><au>Benson, Christina G</au><au>Ostapoff, E.-Michael</au><au>Morest, D.Kent</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glycine immunoreactive projections from the dorsal to the anteroventral cochlear nucleus</atitle><jtitle>Hearing research</jtitle><addtitle>Hear Res</addtitle><date>1991</date><risdate>1991</risdate><volume>51</volume><issue>1</issue><spage>11</spage><epage>28</epage><pages>11-28</pages><issn>0378-5955</issn><eissn>1878-5891</eissn><coden>HERED3</coden><abstract>The aim of the present study was to investigate whether projections from the dorsal cochlear nucleus (DCN) to the anteroventral cochlear nucleus (AVCN) use either of two inhibitory transmitters, glycine or GABA. Retrograde HRP labeling of DCN-to-AVCN projection neurons was combined with postembedding immunocytochemistry in the DCN of guinea pigs. Following injections of HRP in the anterior or posterior divisions of AVCN, large numbers of neurons were labeled in the DCN. All of these were located in the deep layer, except for a few granule cells. Nearly all (96%) of the projection neurons were immunoreactive for glycine and most had dendritic and somatic morphologies corresponding to those of elongate neurons (so-called ‘corn’ cells); only a few resembled small stellate neurons. Few (3%) retrogradely labeled neurons were immunoreactive for GABA. The results suggest that projections from the deep DCN to the AVCN are formed primarily by glycinergic elongate neurons. These projections could have a substantial inhibitory influence on the output of neurons in the AVCN.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>1672865</pmid><doi>10.1016/0378-5955(91)90003-R</doi><tpages>18</tpages></addata></record> |
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| subjects | Animals Auditory pathways Auditory Pathways - anatomy & histology Auditory Pathways - physiology Biological and medical sciences Cochlea - innervation Cochlea - physiology Cochlear nucleus Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation Female Fundamental and applied biological sciences. Psychology GABA gamma-Aminobutyric Acid - physiology Glycine Glycine - physiology Guinea pig Guinea Pigs Horseradish peroxidase Immunocytochemistry Immunohistochemistry Male Neurotransmitter Agents - physiology Vertebrates: nervous system and sense organs |
| title | Glycine immunoreactive projections from the dorsal to the anteroventral cochlear nucleus |
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