Plasma Norepinephrine and Dihydroxyphenylglycol in Essential Hypertension
The aim of the present study was to examine whether essential hypertension is associated with altered plasma concentrations of dihydroxyphenylglycol, the principal presynaptic metabolite of norepinephrine. Forearm venous plasma dihydroxyphenylglycol and norepinephrine were determined at rest and dur...
Gespeichert in:
| Veröffentlicht in: | Hypertension (Dallas, Tex. 1979) Tex. 1979), 1991-04, Vol.17 (4), p.546-552 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 552 |
|---|---|
| container_issue | 4 |
| container_start_page | 546 |
| container_title | Hypertension (Dallas, Tex. 1979) |
| container_volume | 17 |
| creator | Ludwig, Josef Gerlich, Martin Halbriigge, Thomas Graefe, Karl-Heinz |
| description | The aim of the present study was to examine whether essential hypertension is associated with altered plasma concentrations of dihydroxyphenylglycol, the principal presynaptic metabolite of norepinephrine. Forearm venous plasma dihydroxyphenylglycol and norepinephrine were determined at rest and during graded orthostasis in 47 normotensive control subjects and 58 outpatients with essential hypertension. There was no group difference in age. At supine rest as well as during sitting and standing, hypertensive subjects had plasma norepinephrine concentrations similar to those in normotensive control subjects, but plasma dihydroxyphenylglycol concentrations were higher than those in normotensive control subjects. Both groups snowed a linear relation between plasma dihydroxyphenylglycol (ordinate) and plasma norepinephrine (abscissa). The resulting regression line was steeper (p |
| doi_str_mv | 10.1161/01.HYP.17.4.546 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80504078</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>80504078</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4492-8d11d45a3078a72890efa29dee7af6c66405529d568c1437d4f0f2414441cf1d3</originalsourceid><addsrcrecordid>eNpFkE1P3EAMhkdVK1g-zj0h5dLeEuzE-ZhjRYFFQoUDleA0mk6cJjA7SWeyovn3DNpVa8m2LD9-Zb1CfEbIECs8B8zWT_cZ1hllJVUfxArLnFIqq-KjWAFKSiXi46E4CuEZAImoPhAHOWBBDa7Ezb3VYaOTH6PnaXA89T7WRLs2-T70S-vHv8vUs1vsb7uY0SaDSy5DYDcP2ibrZWI_swvD6E7Ep07bwKf7fix-Xl0-XKzT27vrm4tvt6khknnatIgtlbqAutF13kjgTueyZa51V5mqIijLOJdVY5CKuqUOupzeH0fTYVsci6873cmPf7YcZrUZgmFrteNxG1QDJVAUj-D5DjR-DMFzpyY_bLRfFIJ6N08BqmiewlqRiubFi7O99PbXhtt__N6tuP-y3-tgtO28dmYI_2VlA1ICRY523OtoZ_bhxW5f2auetZ17BTEor5oUpcT4KkAaE_PiDc1zhvE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>80504078</pqid></control><display><type>article</type><title>Plasma Norepinephrine and Dihydroxyphenylglycol in Essential Hypertension</title><source>MEDLINE</source><source>EZB Electronic Journals Library</source><source>American Heart Association</source><source>Journals@Ovid Complete</source><creator>Ludwig, Josef ; Gerlich, Martin ; Halbriigge, Thomas ; Graefe, Karl-Heinz</creator><creatorcontrib>Ludwig, Josef ; Gerlich, Martin ; Halbriigge, Thomas ; Graefe, Karl-Heinz</creatorcontrib><description>The aim of the present study was to examine whether essential hypertension is associated with altered plasma concentrations of dihydroxyphenylglycol, the principal presynaptic metabolite of norepinephrine. Forearm venous plasma dihydroxyphenylglycol and norepinephrine were determined at rest and during graded orthostasis in 47 normotensive control subjects and 58 outpatients with essential hypertension. There was no group difference in age. At supine rest as well as during sitting and standing, hypertensive subjects had plasma norepinephrine concentrations similar to those in normotensive control subjects, but plasma dihydroxyphenylglycol concentrations were higher than those in normotensive control subjects. Both groups snowed a linear relation between plasma dihydroxyphenylglycol (ordinate) and plasma norepinephrine (abscissa). The resulting regression line was steeper (p<0.02) and its ordinate intercept higher (/?<0.01) in hypertensive than in control subjects. Eleven normotensive and 14 hypertensive subjects were also tested 3 hours after desipramine (1.5 mg/kg orally) was administered to inhibit neuronal norepinephrine reuptake. The drug did not alter plasma norepinephrine, but did reduce plasma dihydroxyphenylglycol and did abolish plasma dihydroxyphenylglycol responses to upright posture in both groups of subjects. The mean plasma dihydroxyphenylglycol concentration observed in the presence of desipramine again was higher in the hypertensive than in the control group (p<0.01) and closely agreed, in both groups, with the dihydroxyphenylglycol concentration given by the ordinate intercept of the dihydroxyphenylglycol versus norepinephrine regression line in the absence of desipramine. Thus, the desipramine-resistant and desipramine-sensitive component of plasma dihydroxyphenylglycol (i.e., dihydroxyphenylglycol formed from vesicular norepinephrine leaking out of the transmitter stores and from synaptic norepinephrine subsequent to neuronal recapture, respectively) appear to contribute to the elevated plasma dihydroxyphenylglycol concentration in essential hypertension.</description><identifier>ISSN: 0194-911X</identifier><identifier>EISSN: 1524-4563</identifier><identifier>DOI: 10.1161/01.HYP.17.4.546</identifier><identifier>PMID: 2013481</identifier><identifier>CODEN: HPRTDN</identifier><language>eng</language><publisher>Philadelphia, PA: American Heart Association, Inc</publisher><subject>Adult ; Aged ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure ; Cardiology. Vascular system ; Experimental diseases ; Female ; Heart Rate ; Humans ; Hypertension - blood ; Hypertension - physiopathology ; Male ; Medical sciences ; Methoxyhydroxyphenylglycol - analogs & derivatives ; Methoxyhydroxyphenylglycol - blood ; Middle Aged ; Norepinephrine - blood</subject><ispartof>Hypertension (Dallas, Tex. 1979), 1991-04, Vol.17 (4), p.546-552</ispartof><rights>1991 American Heart Association, Inc.</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4492-8d11d45a3078a72890efa29dee7af6c66405529d568c1437d4f0f2414441cf1d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19809904$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2013481$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ludwig, Josef</creatorcontrib><creatorcontrib>Gerlich, Martin</creatorcontrib><creatorcontrib>Halbriigge, Thomas</creatorcontrib><creatorcontrib>Graefe, Karl-Heinz</creatorcontrib><title>Plasma Norepinephrine and Dihydroxyphenylglycol in Essential Hypertension</title><title>Hypertension (Dallas, Tex. 1979)</title><addtitle>Hypertension</addtitle><description>The aim of the present study was to examine whether essential hypertension is associated with altered plasma concentrations of dihydroxyphenylglycol, the principal presynaptic metabolite of norepinephrine. Forearm venous plasma dihydroxyphenylglycol and norepinephrine were determined at rest and during graded orthostasis in 47 normotensive control subjects and 58 outpatients with essential hypertension. There was no group difference in age. At supine rest as well as during sitting and standing, hypertensive subjects had plasma norepinephrine concentrations similar to those in normotensive control subjects, but plasma dihydroxyphenylglycol concentrations were higher than those in normotensive control subjects. Both groups snowed a linear relation between plasma dihydroxyphenylglycol (ordinate) and plasma norepinephrine (abscissa). The resulting regression line was steeper (p<0.02) and its ordinate intercept higher (/?<0.01) in hypertensive than in control subjects. Eleven normotensive and 14 hypertensive subjects were also tested 3 hours after desipramine (1.5 mg/kg orally) was administered to inhibit neuronal norepinephrine reuptake. The drug did not alter plasma norepinephrine, but did reduce plasma dihydroxyphenylglycol and did abolish plasma dihydroxyphenylglycol responses to upright posture in both groups of subjects. The mean plasma dihydroxyphenylglycol concentration observed in the presence of desipramine again was higher in the hypertensive than in the control group (p<0.01) and closely agreed, in both groups, with the dihydroxyphenylglycol concentration given by the ordinate intercept of the dihydroxyphenylglycol versus norepinephrine regression line in the absence of desipramine. Thus, the desipramine-resistant and desipramine-sensitive component of plasma dihydroxyphenylglycol (i.e., dihydroxyphenylglycol formed from vesicular norepinephrine leaking out of the transmitter stores and from synaptic norepinephrine subsequent to neuronal recapture, respectively) appear to contribute to the elevated plasma dihydroxyphenylglycol concentration in essential hypertension.</description><subject>Adult</subject><subject>Aged</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure</subject><subject>Cardiology. Vascular system</subject><subject>Experimental diseases</subject><subject>Female</subject><subject>Heart Rate</subject><subject>Humans</subject><subject>Hypertension - blood</subject><subject>Hypertension - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methoxyhydroxyphenylglycol - analogs & derivatives</subject><subject>Methoxyhydroxyphenylglycol - blood</subject><subject>Middle Aged</subject><subject>Norepinephrine - blood</subject><issn>0194-911X</issn><issn>1524-4563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1P3EAMhkdVK1g-zj0h5dLeEuzE-ZhjRYFFQoUDleA0mk6cJjA7SWeyovn3DNpVa8m2LD9-Zb1CfEbIECs8B8zWT_cZ1hllJVUfxArLnFIqq-KjWAFKSiXi46E4CuEZAImoPhAHOWBBDa7Ezb3VYaOTH6PnaXA89T7WRLs2-T70S-vHv8vUs1vsb7uY0SaDSy5DYDcP2ibrZWI_swvD6E7Ep07bwKf7fix-Xl0-XKzT27vrm4tvt6khknnatIgtlbqAutF13kjgTueyZa51V5mqIijLOJdVY5CKuqUOupzeH0fTYVsci6873cmPf7YcZrUZgmFrteNxG1QDJVAUj-D5DjR-DMFzpyY_bLRfFIJ6N08BqmiewlqRiubFi7O99PbXhtt__N6tuP-y3-tgtO28dmYI_2VlA1ICRY523OtoZ_bhxW5f2auetZ17BTEor5oUpcT4KkAaE_PiDc1zhvE</recordid><startdate>199104</startdate><enddate>199104</enddate><creator>Ludwig, Josef</creator><creator>Gerlich, Martin</creator><creator>Halbriigge, Thomas</creator><creator>Graefe, Karl-Heinz</creator><general>American Heart Association, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199104</creationdate><title>Plasma Norepinephrine and Dihydroxyphenylglycol in Essential Hypertension</title><author>Ludwig, Josef ; Gerlich, Martin ; Halbriigge, Thomas ; Graefe, Karl-Heinz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4492-8d11d45a3078a72890efa29dee7af6c66405529d568c1437d4f0f2414441cf1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Pressure</topic><topic>Cardiology. Vascular system</topic><topic>Experimental diseases</topic><topic>Female</topic><topic>Heart Rate</topic><topic>Humans</topic><topic>Hypertension - blood</topic><topic>Hypertension - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methoxyhydroxyphenylglycol - analogs & derivatives</topic><topic>Methoxyhydroxyphenylglycol - blood</topic><topic>Middle Aged</topic><topic>Norepinephrine - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ludwig, Josef</creatorcontrib><creatorcontrib>Gerlich, Martin</creatorcontrib><creatorcontrib>Halbriigge, Thomas</creatorcontrib><creatorcontrib>Graefe, Karl-Heinz</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ludwig, Josef</au><au>Gerlich, Martin</au><au>Halbriigge, Thomas</au><au>Graefe, Karl-Heinz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma Norepinephrine and Dihydroxyphenylglycol in Essential Hypertension</atitle><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle><addtitle>Hypertension</addtitle><date>1991-04</date><risdate>1991</risdate><volume>17</volume><issue>4</issue><spage>546</spage><epage>552</epage><pages>546-552</pages><issn>0194-911X</issn><eissn>1524-4563</eissn><coden>HPRTDN</coden><abstract>The aim of the present study was to examine whether essential hypertension is associated with altered plasma concentrations of dihydroxyphenylglycol, the principal presynaptic metabolite of norepinephrine. Forearm venous plasma dihydroxyphenylglycol and norepinephrine were determined at rest and during graded orthostasis in 47 normotensive control subjects and 58 outpatients with essential hypertension. There was no group difference in age. At supine rest as well as during sitting and standing, hypertensive subjects had plasma norepinephrine concentrations similar to those in normotensive control subjects, but plasma dihydroxyphenylglycol concentrations were higher than those in normotensive control subjects. Both groups snowed a linear relation between plasma dihydroxyphenylglycol (ordinate) and plasma norepinephrine (abscissa). The resulting regression line was steeper (p<0.02) and its ordinate intercept higher (/?<0.01) in hypertensive than in control subjects. Eleven normotensive and 14 hypertensive subjects were also tested 3 hours after desipramine (1.5 mg/kg orally) was administered to inhibit neuronal norepinephrine reuptake. The drug did not alter plasma norepinephrine, but did reduce plasma dihydroxyphenylglycol and did abolish plasma dihydroxyphenylglycol responses to upright posture in both groups of subjects. The mean plasma dihydroxyphenylglycol concentration observed in the presence of desipramine again was higher in the hypertensive than in the control group (p<0.01) and closely agreed, in both groups, with the dihydroxyphenylglycol concentration given by the ordinate intercept of the dihydroxyphenylglycol versus norepinephrine regression line in the absence of desipramine. Thus, the desipramine-resistant and desipramine-sensitive component of plasma dihydroxyphenylglycol (i.e., dihydroxyphenylglycol formed from vesicular norepinephrine leaking out of the transmitter stores and from synaptic norepinephrine subsequent to neuronal recapture, respectively) appear to contribute to the elevated plasma dihydroxyphenylglycol concentration in essential hypertension.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>2013481</pmid><doi>10.1161/01.HYP.17.4.546</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0194-911X |
| ispartof | Hypertension (Dallas, Tex. 1979), 1991-04, Vol.17 (4), p.546-552 |
| issn | 0194-911X 1524-4563 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80504078 |
| source | MEDLINE; EZB Electronic Journals Library; American Heart Association; Journals@Ovid Complete |
| subjects | Adult Aged Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure Cardiology. Vascular system Experimental diseases Female Heart Rate Humans Hypertension - blood Hypertension - physiopathology Male Medical sciences Methoxyhydroxyphenylglycol - analogs & derivatives Methoxyhydroxyphenylglycol - blood Middle Aged Norepinephrine - blood |
| title | Plasma Norepinephrine and Dihydroxyphenylglycol in Essential Hypertension |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T20%3A34%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Plasma%20Norepinephrine%20and%20Dihydroxyphenylglycol%20in%20Essential%20Hypertension&rft.jtitle=Hypertension%20(Dallas,%20Tex.%201979)&rft.au=Ludwig,%20Josef&rft.date=1991-04&rft.volume=17&rft.issue=4&rft.spage=546&rft.epage=552&rft.pages=546-552&rft.issn=0194-911X&rft.eissn=1524-4563&rft.coden=HPRTDN&rft_id=info:doi/10.1161/01.HYP.17.4.546&rft_dat=%3Cproquest_cross%3E80504078%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=80504078&rft_id=info:pmid/2013481&rfr_iscdi=true |