Effects of phencyclidine on rat prolactin dopamine receptor and locomotor activity
Plasma prolactin (PRL) was decreased in naive rats sacrificed 30 min after phencyclidine (PCP) administration (10 mg/kg, s.c.). There was, however, no decrease in plasma PRL 30 min after s.c. injection of PCP (10 mg/kg) on the 29th day following 28 days of chronic PCP administration. These data sugg...
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| Veröffentlicht in: | Life sciences (1973) 1983-06, Vol.32 (24), p.2725-2731 |
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| container_end_page | 2731 |
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| container_issue | 24 |
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| container_title | Life sciences (1973) |
| container_volume | 32 |
| creator | Lozovsky, D. Saller, C.F. Bayorh, M.A. Chiueh, C.C. Rice, K.C. Burke, T.R. Kopin, I.J. |
| description | Plasma prolactin (PRL) was decreased in naive rats sacrificed 30 min after phencyclidine (PCP) administration (10 mg/kg, s.c.). There was, however, no decrease in plasma PRL 30 min after s.c. injection of PCP (10 mg/kg) on the 29th day following 28 days of chronic PCP administration. These data suggest the development of tolerance to the PRL-suppressive effect of PCP as result of long-term administration of the drug. The B
max of [
3H]-spiperone binding to rat striatal membranes was decreased 24 hrs after 28 days of PCP treatment without change in affinity (Kd). No indication of the development of tolerance in these rats was found with regard to the locomotor-stimulating effect of PCP. The plasma PRL-suppressive effect of the PCP analog PCMP was found to be stereo-specific; (-) PCMP was much less potent than (+)-PCMP. |
| doi_str_mv | 10.1016/0024-3205(83)90392-2 |
| format | Article |
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3H]-spiperone binding to rat striatal membranes was decreased 24 hrs after 28 days of PCP treatment without change in affinity (Kd). No indication of the development of tolerance in these rats was found with regard to the locomotor-stimulating effect of PCP. The plasma PRL-suppressive effect of the PCP analog PCMP was found to be stereo-specific; (-) PCMP was much less potent than (+)-PCMP.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/0024-3205(83)90392-2</identifier><identifier>PMID: 6855468</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Animals ; Cell Membrane - metabolism ; Corpus Striatum - metabolism ; Drug Administration Schedule ; Male ; Motor Activity - drug effects ; Phencyclidine - administration & dosage ; Phencyclidine - pharmacology ; Prolactin - blood ; Rats ; Rats, Inbred Strains ; Receptors, Dopamine - drug effects ; Receptors, Dopamine - metabolism ; Spiperone - metabolism</subject><ispartof>Life sciences (1973), 1983-06, Vol.32 (24), p.2725-2731</ispartof><rights>1983</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-8a75c0c181db168b61d2e23bd6327c7c4883b55df2a1c1d0b9d6a0d532aad99e3</citedby><cites>FETCH-LOGICAL-c357t-8a75c0c181db168b61d2e23bd6327c7c4883b55df2a1c1d0b9d6a0d532aad99e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0024-3205(83)90392-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6855468$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lozovsky, D.</creatorcontrib><creatorcontrib>Saller, C.F.</creatorcontrib><creatorcontrib>Bayorh, M.A.</creatorcontrib><creatorcontrib>Chiueh, C.C.</creatorcontrib><creatorcontrib>Rice, K.C.</creatorcontrib><creatorcontrib>Burke, T.R.</creatorcontrib><creatorcontrib>Kopin, I.J.</creatorcontrib><title>Effects of phencyclidine on rat prolactin dopamine receptor and locomotor activity</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>Plasma prolactin (PRL) was decreased in naive rats sacrificed 30 min after phencyclidine (PCP) administration (10 mg/kg, s.c.). There was, however, no decrease in plasma PRL 30 min after s.c. injection of PCP (10 mg/kg) on the 29th day following 28 days of chronic PCP administration. These data suggest the development of tolerance to the PRL-suppressive effect of PCP as result of long-term administration of the drug. The B
max of [
3H]-spiperone binding to rat striatal membranes was decreased 24 hrs after 28 days of PCP treatment without change in affinity (Kd). No indication of the development of tolerance in these rats was found with regard to the locomotor-stimulating effect of PCP. The plasma PRL-suppressive effect of the PCP analog PCMP was found to be stereo-specific; (-) PCMP was much less potent than (+)-PCMP.</description><subject>Animals</subject><subject>Cell Membrane - metabolism</subject><subject>Corpus Striatum - metabolism</subject><subject>Drug Administration Schedule</subject><subject>Male</subject><subject>Motor Activity - drug effects</subject><subject>Phencyclidine - administration & dosage</subject><subject>Phencyclidine - pharmacology</subject><subject>Prolactin - blood</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Receptors, Dopamine - drug effects</subject><subject>Receptors, Dopamine - metabolism</subject><subject>Spiperone - metabolism</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLAzEUhYMotVb_gUJWoovRPCaZzEaQUh9QEETXIZNkMDIzGZO00H9vakuXri6Xc859fABcYnSHEeb3CJGyoASxG0Fva0RrUpAjMMWiqgvEKT4G04PlFJzF-I0QYqyiEzDhgrGSiyl4X7St1SlC38Lxyw56oztn3GChH2BQCY7Bd0onN0DjR9VvlWC1HZMPUA0Gdl773v912bV2aXMOTlrVRXuxrzPw-bT4mL8Uy7fn1_njstCUVakQqmIaaSywaTAXDceGWEIbwympdKVLIWjDmGmJwhob1NSGK2QYJUqZurZ0Bq53c_OJPysbk-xd1Lbr1GD9KkqByroWuMrGcmfUwccYbCvH4HoVNhIjuUUpt5zklpMUVP6hlCTHrvbzV01vzSG0Z5f1h51u85NrZ4OM2mWC1rhMKEnj3f8LfgFBdYOs</recordid><startdate>19830613</startdate><enddate>19830613</enddate><creator>Lozovsky, D.</creator><creator>Saller, C.F.</creator><creator>Bayorh, M.A.</creator><creator>Chiueh, C.C.</creator><creator>Rice, K.C.</creator><creator>Burke, T.R.</creator><creator>Kopin, I.J.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19830613</creationdate><title>Effects of phencyclidine on rat prolactin dopamine receptor and locomotor activity</title><author>Lozovsky, D. ; Saller, C.F. ; Bayorh, M.A. ; Chiueh, C.C. ; Rice, K.C. ; Burke, T.R. ; Kopin, I.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-8a75c0c181db168b61d2e23bd6327c7c4883b55df2a1c1d0b9d6a0d532aad99e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Animals</topic><topic>Cell Membrane - metabolism</topic><topic>Corpus Striatum - metabolism</topic><topic>Drug Administration Schedule</topic><topic>Male</topic><topic>Motor Activity - drug effects</topic><topic>Phencyclidine - administration & dosage</topic><topic>Phencyclidine - pharmacology</topic><topic>Prolactin - blood</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Receptors, Dopamine - drug effects</topic><topic>Receptors, Dopamine - metabolism</topic><topic>Spiperone - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lozovsky, D.</creatorcontrib><creatorcontrib>Saller, C.F.</creatorcontrib><creatorcontrib>Bayorh, M.A.</creatorcontrib><creatorcontrib>Chiueh, C.C.</creatorcontrib><creatorcontrib>Rice, K.C.</creatorcontrib><creatorcontrib>Burke, T.R.</creatorcontrib><creatorcontrib>Kopin, I.J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lozovsky, D.</au><au>Saller, C.F.</au><au>Bayorh, M.A.</au><au>Chiueh, C.C.</au><au>Rice, K.C.</au><au>Burke, T.R.</au><au>Kopin, I.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of phencyclidine on rat prolactin dopamine receptor and locomotor activity</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1983-06-13</date><risdate>1983</risdate><volume>32</volume><issue>24</issue><spage>2725</spage><epage>2731</epage><pages>2725-2731</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>Plasma prolactin (PRL) was decreased in naive rats sacrificed 30 min after phencyclidine (PCP) administration (10 mg/kg, s.c.). There was, however, no decrease in plasma PRL 30 min after s.c. injection of PCP (10 mg/kg) on the 29th day following 28 days of chronic PCP administration. These data suggest the development of tolerance to the PRL-suppressive effect of PCP as result of long-term administration of the drug. The B
max of [
3H]-spiperone binding to rat striatal membranes was decreased 24 hrs after 28 days of PCP treatment without change in affinity (Kd). No indication of the development of tolerance in these rats was found with regard to the locomotor-stimulating effect of PCP. The plasma PRL-suppressive effect of the PCP analog PCMP was found to be stereo-specific; (-) PCMP was much less potent than (+)-PCMP.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>6855468</pmid><doi>10.1016/0024-3205(83)90392-2</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0024-3205 |
| ispartof | Life sciences (1973), 1983-06, Vol.32 (24), p.2725-2731 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Cell Membrane - metabolism Corpus Striatum - metabolism Drug Administration Schedule Male Motor Activity - drug effects Phencyclidine - administration & dosage Phencyclidine - pharmacology Prolactin - blood Rats Rats, Inbred Strains Receptors, Dopamine - drug effects Receptors, Dopamine - metabolism Spiperone - metabolism |
| title | Effects of phencyclidine on rat prolactin dopamine receptor and locomotor activity |
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