Acute treatment of Huntington's chorea with lisuride
The authors studied the effects of lisuride hydrogen maleate (lisuride) on the hyperkinesias of 11 patients suffering from Huntington's chorea (HC). In all patients, acute injection of 150 μg of the drug induced a marked temporary improvement of the abnormal involuntary movements; the favourabl...
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| Veröffentlicht in: | Journal of the neurological sciences 1983-05, Vol.59 (2), p.247-253 |
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| container_end_page | 253 |
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| container_title | Journal of the neurological sciences |
| container_volume | 59 |
| creator | Frattola, Lodovico Albizzati, Maria G. Alemani, Alessandro Bassi, Sirio Ferrarese, Carlo Trabucchi, Marco |
| description | The authors studied the effects of lisuride hydrogen maleate (lisuride) on the hyperkinesias of 11 patients suffering from Huntington's chorea (HC).
In all patients, acute injection of 150 μg of the drug induced a marked temporary improvement of the abnormal involuntary movements; the favourable drug-effect was more pronounced in the patients with a less severe degree of hyperkinesia.
The antichoreic activity of the drug was prevented by pretreatment with haloperidol (2 mg) or sulpiride (400 mg), both injected intramuscularly 30 min before lisuride administration.
The authors suggest the improvement of the motor disturbance induced in HC by lisuride may be explained on the basis of its preferential action on a subset of brain dopaminergic receptor. |
| doi_str_mv | 10.1016/0022-510X(83)90042-4 |
| format | Article |
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In all patients, acute injection of 150 μg of the drug induced a marked temporary improvement of the abnormal involuntary movements; the favourable drug-effect was more pronounced in the patients with a less severe degree of hyperkinesia.
The antichoreic activity of the drug was prevented by pretreatment with haloperidol (2 mg) or sulpiride (400 mg), both injected intramuscularly 30 min before lisuride administration.
The authors suggest the improvement of the motor disturbance induced in HC by lisuride may be explained on the basis of its preferential action on a subset of brain dopaminergic receptor.</description><identifier>ISSN: 0022-510X</identifier><identifier>EISSN: 1878-5883</identifier><identifier>DOI: 10.1016/0022-510X(83)90042-4</identifier><identifier>PMID: 6222164</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Clinical Trials as Topic ; Ergolines - therapeutic use ; Female ; Haloperidol - therapeutic use ; Humans ; Huntington Disease - drug therapy ; Lisuride - therapeutic use ; Male ; Placebos ; Sulpiride - therapeutic use</subject><ispartof>Journal of the neurological sciences, 1983-05, Vol.59 (2), p.247-253</ispartof><rights>1983</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-1ca84568640a8eaa6ccba59869638895dedb5c6e30d24f98a63cd691f45bd0723</citedby><cites>FETCH-LOGICAL-c357t-1ca84568640a8eaa6ccba59869638895dedb5c6e30d24f98a63cd691f45bd0723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0022-510X(83)90042-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6222164$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Frattola, Lodovico</creatorcontrib><creatorcontrib>Albizzati, Maria G.</creatorcontrib><creatorcontrib>Alemani, Alessandro</creatorcontrib><creatorcontrib>Bassi, Sirio</creatorcontrib><creatorcontrib>Ferrarese, Carlo</creatorcontrib><creatorcontrib>Trabucchi, Marco</creatorcontrib><title>Acute treatment of Huntington's chorea with lisuride</title><title>Journal of the neurological sciences</title><addtitle>J Neurol Sci</addtitle><description>The authors studied the effects of lisuride hydrogen maleate (lisuride) on the hyperkinesias of 11 patients suffering from Huntington's chorea (HC).
In all patients, acute injection of 150 μg of the drug induced a marked temporary improvement of the abnormal involuntary movements; the favourable drug-effect was more pronounced in the patients with a less severe degree of hyperkinesia.
The antichoreic activity of the drug was prevented by pretreatment with haloperidol (2 mg) or sulpiride (400 mg), both injected intramuscularly 30 min before lisuride administration.
The authors suggest the improvement of the motor disturbance induced in HC by lisuride may be explained on the basis of its preferential action on a subset of brain dopaminergic receptor.</description><subject>Clinical Trials as Topic</subject><subject>Ergolines - therapeutic use</subject><subject>Female</subject><subject>Haloperidol - therapeutic use</subject><subject>Humans</subject><subject>Huntington Disease - drug therapy</subject><subject>Lisuride - therapeutic use</subject><subject>Male</subject><subject>Placebos</subject><subject>Sulpiride - therapeutic use</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kElLAzEUx4MotVa_gcKcXA6j2SZNLkIpblDwouAtZJI3NjJLTTKK396pLT16eof_8t77IXRK8DXBRNxgTGleEPx2KdmVwpjTnO-hMZFTmRdSsn003lkO0VGMHxhjIaUaoZGglBLBx4jPbJ8gSwFMaqBNWVdlj32bfPueuvYiZnbZDVr27dMyq33sg3dwjA4qU0c42c4Jer2_e5k_5ovnh6f5bJFbVkxTTqyRvBBScGwkGCOsLU2hpFCCDWcUDlxZWAEMO8orJY1g1glFKl6UDk8pm6DzTe8qdJ89xKQbHy3UtWmh66OWmCvFuRqMfGO0oYsxQKVXwTcm_GiC9RqWXpPQaxJaMv0HS_Mhdrbt78sG3C60pTPotxsdhie_PAQdrYfWgvMBbNKu8_8v-AVQfXgi</recordid><startdate>198305</startdate><enddate>198305</enddate><creator>Frattola, Lodovico</creator><creator>Albizzati, Maria G.</creator><creator>Alemani, Alessandro</creator><creator>Bassi, Sirio</creator><creator>Ferrarese, Carlo</creator><creator>Trabucchi, Marco</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198305</creationdate><title>Acute treatment of Huntington's chorea with lisuride</title><author>Frattola, Lodovico ; Albizzati, Maria G. ; Alemani, Alessandro ; Bassi, Sirio ; Ferrarese, Carlo ; Trabucchi, Marco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-1ca84568640a8eaa6ccba59869638895dedb5c6e30d24f98a63cd691f45bd0723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Clinical Trials as Topic</topic><topic>Ergolines - therapeutic use</topic><topic>Female</topic><topic>Haloperidol - therapeutic use</topic><topic>Humans</topic><topic>Huntington Disease - drug therapy</topic><topic>Lisuride - therapeutic use</topic><topic>Male</topic><topic>Placebos</topic><topic>Sulpiride - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Frattola, Lodovico</creatorcontrib><creatorcontrib>Albizzati, Maria G.</creatorcontrib><creatorcontrib>Alemani, Alessandro</creatorcontrib><creatorcontrib>Bassi, Sirio</creatorcontrib><creatorcontrib>Ferrarese, Carlo</creatorcontrib><creatorcontrib>Trabucchi, Marco</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Frattola, Lodovico</au><au>Albizzati, Maria G.</au><au>Alemani, Alessandro</au><au>Bassi, Sirio</au><au>Ferrarese, Carlo</au><au>Trabucchi, Marco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute treatment of Huntington's chorea with lisuride</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>1983-05</date><risdate>1983</risdate><volume>59</volume><issue>2</issue><spage>247</spage><epage>253</epage><pages>247-253</pages><issn>0022-510X</issn><eissn>1878-5883</eissn><abstract>The authors studied the effects of lisuride hydrogen maleate (lisuride) on the hyperkinesias of 11 patients suffering from Huntington's chorea (HC).
In all patients, acute injection of 150 μg of the drug induced a marked temporary improvement of the abnormal involuntary movements; the favourable drug-effect was more pronounced in the patients with a less severe degree of hyperkinesia.
The antichoreic activity of the drug was prevented by pretreatment with haloperidol (2 mg) or sulpiride (400 mg), both injected intramuscularly 30 min before lisuride administration.
The authors suggest the improvement of the motor disturbance induced in HC by lisuride may be explained on the basis of its preferential action on a subset of brain dopaminergic receptor.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>6222164</pmid><doi>10.1016/0022-510X(83)90042-4</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of the neurological sciences, 1983-05, Vol.59 (2), p.247-253 |
| issn | 0022-510X 1878-5883 |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Clinical Trials as Topic Ergolines - therapeutic use Female Haloperidol - therapeutic use Humans Huntington Disease - drug therapy Lisuride - therapeutic use Male Placebos Sulpiride - therapeutic use |
| title | Acute treatment of Huntington's chorea with lisuride |
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