Technetium-99m(Sn2+)Pyrophosphate in Ischemic and Infarcted Dog Myocardium in Early Stages of Acute Coronary Occlusion: Histochemical and Tissue-Counting Comparisons
We have investigated the pattern of accumulation of Tc-99m(Sn2+)pyrophosphate (Tc-99m PPi) in myocardial tissue of dogs during the early stages of acute occlusion of the left anterior descending coronary artery. Three groups were studied after: (a) 40 min occlusion followed by 6 hr reperfusion (n =...
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| Veröffentlicht in: | The Journal of nuclear medicine (1978) 1983-06, Vol.24 (6), p.485-491 |
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| container_end_page | 491 |
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| container_issue | 6 |
| container_start_page | 485 |
| container_title | The Journal of nuclear medicine (1978) |
| container_volume | 24 |
| creator | Bianco, Jesus A Kemper, Andrew J Taylor, Arthur Lazewatsky, Joel Tow, Donald E Khuri, Shukri F |
| description | We have investigated the pattern of accumulation of Tc-99m(Sn2+)pyrophosphate (Tc-99m PPi) in myocardial tissue of dogs during the early stages of acute occlusion of the left anterior descending coronary artery. Three groups were studied after: (a) 40 min occlusion followed by 6 hr reperfusion (n = 6); (b) 6 hr occlusion followed by one hour reperfusion (n = 5); and (c) 7 hr occlusion with no reperfusion (n = 4). Areas of myocardial infarction were defined with triphenyl-tetrazolium chloride (TTC) staining, and blood flow was determined with 9-mu radioactive microspheres. In Group C uptake in infarcted and peri-infarct areas was not enhanced, most likely owing to low flow. In Group B, with late reperfusion, Tc-99m PPi sequestration was increased in both infarcted and peri-infarcted tissues. In Group A, areas ischemic during occlusion but with normal flow and viability by TTC after 6 hr of reperfusion showed significant uptake of Tc-99m PPi (twice the uptake of nonischemic regions). |
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Three groups were studied after: (a) 40 min occlusion followed by 6 hr reperfusion (n = 6); (b) 6 hr occlusion followed by one hour reperfusion (n = 5); and (c) 7 hr occlusion with no reperfusion (n = 4). Areas of myocardial infarction were defined with triphenyl-tetrazolium chloride (TTC) staining, and blood flow was determined with 9-mu radioactive microspheres. In Group C uptake in infarcted and peri-infarct areas was not enhanced, most likely owing to low flow. In Group B, with late reperfusion, Tc-99m PPi sequestration was increased in both infarcted and peri-infarcted tissues. In Group A, areas ischemic during occlusion but with normal flow and viability by TTC after 6 hr of reperfusion showed significant uptake of Tc-99m PPi (twice the uptake of nonischemic regions).</description><identifier>ISSN: 0161-5505</identifier><identifier>EISSN: 1535-5667</identifier><identifier>PMID: 6854398</identifier><language>eng</language><publisher>United States: Soc Nuclear Med</publisher><subject>Animals ; Coronary Circulation ; Coronary Disease - diagnostic imaging ; Coronary Disease - pathology ; Dogs ; Female ; Histocytochemistry ; Male ; Models, Biological ; Myocardial Infarction - diagnostic imaging ; Myocardial Infarction - pathology ; Polyphosphates ; Radionuclide Imaging ; Regional Blood Flow ; Technetium ; Technetium Tc 99m Pyrophosphate ; Tin Polyphosphates</subject><ispartof>The Journal of nuclear medicine (1978), 1983-06, Vol.24 (6), p.485-491</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6854398$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bianco, Jesus A</creatorcontrib><creatorcontrib>Kemper, Andrew J</creatorcontrib><creatorcontrib>Taylor, Arthur</creatorcontrib><creatorcontrib>Lazewatsky, Joel</creatorcontrib><creatorcontrib>Tow, Donald E</creatorcontrib><creatorcontrib>Khuri, Shukri F</creatorcontrib><title>Technetium-99m(Sn2+)Pyrophosphate in Ischemic and Infarcted Dog Myocardium in Early Stages of Acute Coronary Occlusion: Histochemical and Tissue-Counting Comparisons</title><title>The Journal of nuclear medicine (1978)</title><addtitle>J Nucl Med</addtitle><description>We have investigated the pattern of accumulation of Tc-99m(Sn2+)pyrophosphate (Tc-99m PPi) in myocardial tissue of dogs during the early stages of acute occlusion of the left anterior descending coronary artery. Three groups were studied after: (a) 40 min occlusion followed by 6 hr reperfusion (n = 6); (b) 6 hr occlusion followed by one hour reperfusion (n = 5); and (c) 7 hr occlusion with no reperfusion (n = 4). Areas of myocardial infarction were defined with triphenyl-tetrazolium chloride (TTC) staining, and blood flow was determined with 9-mu radioactive microspheres. In Group C uptake in infarcted and peri-infarct areas was not enhanced, most likely owing to low flow. In Group B, with late reperfusion, Tc-99m PPi sequestration was increased in both infarcted and peri-infarcted tissues. In Group A, areas ischemic during occlusion but with normal flow and viability by TTC after 6 hr of reperfusion showed significant uptake of Tc-99m PPi (twice the uptake of nonischemic regions).</description><subject>Animals</subject><subject>Coronary Circulation</subject><subject>Coronary Disease - diagnostic imaging</subject><subject>Coronary Disease - pathology</subject><subject>Dogs</subject><subject>Female</subject><subject>Histocytochemistry</subject><subject>Male</subject><subject>Models, Biological</subject><subject>Myocardial Infarction - diagnostic imaging</subject><subject>Myocardial Infarction - pathology</subject><subject>Polyphosphates</subject><subject>Radionuclide Imaging</subject><subject>Regional Blood Flow</subject><subject>Technetium</subject><subject>Technetium Tc 99m Pyrophosphate</subject><subject>Tin Polyphosphates</subject><issn>0161-5505</issn><issn>1535-5667</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkF1LwzAYhYsoOqc_QciVKFJIlr5d453Mr4EywXld0uTtGmmTmjTIfpD_06oDr87Ncx44Zy-ZMOCQQp7P95MJZTlLASgcJcchvFNK86IoDpPDvICMi2KSfK1RNRYHE7tUiO7i1c6uLl-23vWNC30jByTGkmVQDXZGEWk1WdpaejWgJrduQ563Tkmvx_4PeCd9uyWvg9xgIK4mNyqOhoXzzkq_JSul2hiMs9fk0YTB_Vll--tdmxAipgsX7WDsZmx1vfQmOBtOkoNatgFPdzlN3u7v1ovH9Gn1sFzcPKXNjM-HVFesrrigUAFToFktuBac1gjIRqAGJpjAImMaaKXmMkMEPVN5pWvgCJxPk_M_b-_dR8QwlJ0JCttWWnQxlAXNhOCcjuDZDoxVh7rsvenGgeXu139RYzbNp_FY2qhalP4HfrfdLCvzMiuAfwOeDoV7</recordid><startdate>198306</startdate><enddate>198306</enddate><creator>Bianco, Jesus A</creator><creator>Kemper, Andrew J</creator><creator>Taylor, Arthur</creator><creator>Lazewatsky, Joel</creator><creator>Tow, Donald E</creator><creator>Khuri, Shukri F</creator><general>Soc Nuclear Med</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>198306</creationdate><title>Technetium-99m(Sn2+)Pyrophosphate in Ischemic and Infarcted Dog Myocardium in Early Stages of Acute Coronary Occlusion: Histochemical and Tissue-Counting Comparisons</title><author>Bianco, Jesus A ; Kemper, Andrew J ; Taylor, Arthur ; Lazewatsky, Joel ; Tow, Donald E ; Khuri, Shukri F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h237t-db1fb3905b51c5d1f93d930fe5e1237f51919e841d50bc7a4ee5d2c6bdf53e533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Animals</topic><topic>Coronary Circulation</topic><topic>Coronary Disease - diagnostic imaging</topic><topic>Coronary Disease - pathology</topic><topic>Dogs</topic><topic>Female</topic><topic>Histocytochemistry</topic><topic>Male</topic><topic>Models, Biological</topic><topic>Myocardial Infarction - diagnostic imaging</topic><topic>Myocardial Infarction - pathology</topic><topic>Polyphosphates</topic><topic>Radionuclide Imaging</topic><topic>Regional Blood Flow</topic><topic>Technetium</topic><topic>Technetium Tc 99m Pyrophosphate</topic><topic>Tin Polyphosphates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bianco, Jesus A</creatorcontrib><creatorcontrib>Kemper, Andrew J</creatorcontrib><creatorcontrib>Taylor, Arthur</creatorcontrib><creatorcontrib>Lazewatsky, Joel</creatorcontrib><creatorcontrib>Tow, Donald E</creatorcontrib><creatorcontrib>Khuri, Shukri F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nuclear medicine (1978)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bianco, Jesus A</au><au>Kemper, Andrew J</au><au>Taylor, Arthur</au><au>Lazewatsky, Joel</au><au>Tow, Donald E</au><au>Khuri, Shukri F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Technetium-99m(Sn2+)Pyrophosphate in Ischemic and Infarcted Dog Myocardium in Early Stages of Acute Coronary Occlusion: Histochemical and Tissue-Counting Comparisons</atitle><jtitle>The Journal of nuclear medicine (1978)</jtitle><addtitle>J Nucl Med</addtitle><date>1983-06</date><risdate>1983</risdate><volume>24</volume><issue>6</issue><spage>485</spage><epage>491</epage><pages>485-491</pages><issn>0161-5505</issn><eissn>1535-5667</eissn><abstract>We have investigated the pattern of accumulation of Tc-99m(Sn2+)pyrophosphate (Tc-99m PPi) in myocardial tissue of dogs during the early stages of acute occlusion of the left anterior descending coronary artery. Three groups were studied after: (a) 40 min occlusion followed by 6 hr reperfusion (n = 6); (b) 6 hr occlusion followed by one hour reperfusion (n = 5); and (c) 7 hr occlusion with no reperfusion (n = 4). Areas of myocardial infarction were defined with triphenyl-tetrazolium chloride (TTC) staining, and blood flow was determined with 9-mu radioactive microspheres. In Group C uptake in infarcted and peri-infarct areas was not enhanced, most likely owing to low flow. In Group B, with late reperfusion, Tc-99m PPi sequestration was increased in both infarcted and peri-infarcted tissues. In Group A, areas ischemic during occlusion but with normal flow and viability by TTC after 6 hr of reperfusion showed significant uptake of Tc-99m PPi (twice the uptake of nonischemic regions).</abstract><cop>United States</cop><pub>Soc Nuclear Med</pub><pmid>6854398</pmid><tpages>7</tpages></addata></record> |
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| ispartof | The Journal of nuclear medicine (1978), 1983-06, Vol.24 (6), p.485-491 |
| issn | 0161-5505 1535-5667 |
| language | eng |
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| subjects | Animals Coronary Circulation Coronary Disease - diagnostic imaging Coronary Disease - pathology Dogs Female Histocytochemistry Male Models, Biological Myocardial Infarction - diagnostic imaging Myocardial Infarction - pathology Polyphosphates Radionuclide Imaging Regional Blood Flow Technetium Technetium Tc 99m Pyrophosphate Tin Polyphosphates |
| title | Technetium-99m(Sn2+)Pyrophosphate in Ischemic and Infarcted Dog Myocardium in Early Stages of Acute Coronary Occlusion: Histochemical and Tissue-Counting Comparisons |
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