A Study of the Percutaneous Absorption from Topically Applied Zinc Oxide Ointment
The systemic absorption from topical applications of 40% zinc oxide ointment was investigated in a series of healthy subjects (phase one) and in patients receiving total parenteral nutrition (phase two). In the first phase, six subjects completed a controlled, cross-over trial involving 3 hourly ser...
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| Veröffentlicht in: | JPEN. Journal of parenteral and enteral nutrition 1983-03, Vol.7 (2), p.131-135 |
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| container_title | JPEN. Journal of parenteral and enteral nutrition |
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| creator | Derry, John E. McLean, William M. Freeman, Joel B. |
| description | The systemic absorption from topical applications of 40% zinc oxide ointment was investigated in a series of healthy subjects (phase one) and in patients receiving total parenteral nutrition (phase two). In the first phase, six subjects completed a controlled, cross-over trial involving 3 hourly serum sample determinations for zinc concentration following a massive application of 40% zinc oxide ointment and plain petrolatum ointment. There was a mean increase in serum zinc from 107.3 ± 5.32 to 116.1 ± 5.02 μg/dL 1 hr after application of 40% zinc oxide ointment (p > 0.05). Three patients receiving total parenteral nutrition completed phase two of the protocol in which 40% zinc oxide ointment was applied daily to a specified area of the thigh. Analysis of these patients' serum revealed that the zinc concentrations remained relatively constant over the 10-day study period. These findings suggest that topical applications of 40% zinc oxide ointment do not result in significant absorption. This study serves as a starting point for further investigation. |
| doi_str_mv | 10.1177/0148607183007002131 |
| format | Article |
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Journal of parenteral and enteral nutrition</title><addtitle>JPEN J Parenter Enteral Nutr</addtitle><description>The systemic absorption from topical applications of 40% zinc oxide ointment was investigated in a series of healthy subjects (phase one) and in patients receiving total parenteral nutrition (phase two). In the first phase, six subjects completed a controlled, cross-over trial involving 3 hourly serum sample determinations for zinc concentration following a massive application of 40% zinc oxide ointment and plain petrolatum ointment. There was a mean increase in serum zinc from 107.3 ± 5.32 to 116.1 ± 5.02 μg/dL 1 hr after application of 40% zinc oxide ointment (p > 0.05). Three patients receiving total parenteral nutrition completed phase two of the protocol in which 40% zinc oxide ointment was applied daily to a specified area of the thigh. Analysis of these patients' serum revealed that the zinc concentrations remained relatively constant over the 10-day study period. These findings suggest that topical applications of 40% zinc oxide ointment do not result in significant absorption. This study serves as a starting point for further investigation.</description><subject>Administration, Topical</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Clinical Trials as Topic</subject><subject>Female</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Ointments</subject><subject>Parenteral Nutrition</subject><subject>Parenteral Nutrition, Total - adverse effects</subject><subject>Skin Absorption</subject><subject>Zinc - administration & dosage</subject><subject>Zinc - blood</subject><subject>Zinc - deficiency</subject><subject>Zinc Oxide - administration & dosage</subject><subject>Zinc Oxide - metabolism</subject><issn>0148-6071</issn><issn>1941-2444</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkD1PwzAURS0EKqXwCxCSJ7bAc-M49lhVfKqiRXRiiZzkBVwlcbATQf49rVIxIcT0hnvu0dMl5JzBFWNxfA2MSwExkyFADDBlITsgY6Y4C6ac80My3hHBDjkmJ95vACAUACMyEhyEUGpMnmf0pe3yntqCtu9IV-iyrtU12s7TWeqta1pja1o4W9G1bUymy7Kns6YpDeb01dQZXX6ZHOnS1G2FdXtKjgpdejzb3wlZ396s5_fBYnn3MJ8tgixUjAWq4Kg4zyMNKYecMy1RMhExoVWuoohpUagsjoGHUSojjAQqCSBkGPM04-GEXA7axtmPDn2bVMZnWJbD74kEroSQ0y0YDmDmrPcOi6RxptKuTxgkux2TX3bcti72-i6tMP_p7Ifb5mrIP02J_X-UyePq5gkGNwxdr98w2djO1duh_nznG_IpiT0</recordid><startdate>198303</startdate><enddate>198303</enddate><creator>Derry, John E.</creator><creator>McLean, William M.</creator><creator>Freeman, Joel B.</creator><general>Sage Publications</general><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198303</creationdate><title>A Study of the Percutaneous Absorption from Topically Applied Zinc Oxide Ointment</title><author>Derry, John E. ; McLean, William M. ; Freeman, Joel B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3911-9f4e944d5a0b40d41a8e816516a9d9551a6f9c770435b85e56e980068374bc43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Administration, Topical</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Clinical Trials as Topic</topic><topic>Female</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Ointments</topic><topic>Parenteral Nutrition</topic><topic>Parenteral Nutrition, Total - adverse effects</topic><topic>Skin Absorption</topic><topic>Zinc - administration & dosage</topic><topic>Zinc - blood</topic><topic>Zinc - deficiency</topic><topic>Zinc Oxide - administration & dosage</topic><topic>Zinc Oxide - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Derry, John E.</creatorcontrib><creatorcontrib>McLean, William M.</creatorcontrib><creatorcontrib>Freeman, Joel B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>JPEN. 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This study serves as a starting point for further investigation.</abstract><cop>Thousand Oaks, CA</cop><pub>Sage Publications</pub><pmid>6406699</pmid><doi>10.1177/0148607183007002131</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0148-6071 |
| ispartof | JPEN. Journal of parenteral and enteral nutrition, 1983-03, Vol.7 (2), p.131-135 |
| issn | 0148-6071 1941-2444 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80496682 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Administration, Topical Adolescent Adult Aged Clinical Trials as Topic Female Humans In Vitro Techniques Male Middle Aged Ointments Parenteral Nutrition Parenteral Nutrition, Total - adverse effects Skin Absorption Zinc - administration & dosage Zinc - blood Zinc - deficiency Zinc Oxide - administration & dosage Zinc Oxide - metabolism |
| title | A Study of the Percutaneous Absorption from Topically Applied Zinc Oxide Ointment |
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