8;20 chromosomal translocation in a case of acute leukemia: Cytogenetic, immunophenotypic, ultrastructural, and molecular characteristics
An 8;20 chromosomal translocation was observed in the leukemia cells of a 3-year-old girl. To our knowledge, this is the first report of this translocation in de novo acute leukemia. This chromosomal defect was present in the leukemia cells at diagnosis and also at relapse, but remission bone marrow...
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| Veröffentlicht in: | Cancer genetics and cytogenetics 1991-03, Vol.52 (1), p.1-9 |
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| container_title | Cancer genetics and cytogenetics |
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| creator | Jorgenson, Keith F. Antoun, Gamil R. Childs, Craig C. Felix, Edward A. Cork, Ann Yee, Garland Trujillo, Jose M. Pinkel, Donald P. Zipf, Theodore F. |
| description | An 8;20 chromosomal translocation was observed in the leukemia cells of a 3-year-old girl. To our knowledge, this is the first report of this translocation in de novo acute leukemia. This chromosomal defect was present in the leukemia cells at diagnosis and also at relapse, but remission bone marrow cells had the 46,XX karyotype. By morphologic and cytochemical criteria the leukemia was myeloid but these features were more lymphoid when the leukemia recurred. However, the immunophenotype was consistent with myeloid leukemia and did not change at relapse. No evidence for either immunoglobulin or TCR gene rearrangement was observed. |
| doi_str_mv | 10.1016/0165-4608(91)90047-X |
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To our knowledge, this is the first report of this translocation in de novo acute leukemia. This chromosomal defect was present in the leukemia cells at diagnosis and also at relapse, but remission bone marrow cells had the 46,XX karyotype. By morphologic and cytochemical criteria the leukemia was myeloid but these features were more lymphoid when the leukemia recurred. However, the immunophenotype was consistent with myeloid leukemia and did not change at relapse. No evidence for either immunoglobulin or TCR gene rearrangement was observed.</description><identifier>ISSN: 0165-4608</identifier><identifier>EISSN: 1873-4456</identifier><identifier>DOI: 10.1016/0165-4608(91)90047-X</identifier><identifier>PMID: 2009503</identifier><identifier>CODEN: CGCYDF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Biological and medical sciences ; Biomarkers, Tumor ; Child, Preschool ; chromosome 20 ; chromosome 8 ; Chromosomes, Human, Pair 20 ; Chromosomes, Human, Pair 8 ; Female ; Genetic Markers ; Hematologic and hematopoietic diseases ; Humans ; Immunophenotyping ; Karyotyping ; Leukemia, Myeloid, Acute - genetics ; Leukemia, Myeloid, Acute - immunology ; Leukemia, Myeloid, Acute - pathology ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Medical sciences ; translocation ; Translocation, Genetic - genetics</subject><ispartof>Cancer genetics and cytogenetics, 1991-03, Vol.52 (1), p.1-9</ispartof><rights>1991</rights><rights>1992 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0165-4608(91)90047-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5456464$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2009503$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jorgenson, Keith F.</creatorcontrib><creatorcontrib>Antoun, Gamil R.</creatorcontrib><creatorcontrib>Childs, Craig C.</creatorcontrib><creatorcontrib>Felix, Edward A.</creatorcontrib><creatorcontrib>Cork, Ann</creatorcontrib><creatorcontrib>Yee, Garland</creatorcontrib><creatorcontrib>Trujillo, Jose M.</creatorcontrib><creatorcontrib>Pinkel, Donald P.</creatorcontrib><creatorcontrib>Zipf, Theodore F.</creatorcontrib><title>8;20 chromosomal translocation in a case of acute leukemia: Cytogenetic, immunophenotypic, ultrastructural, and molecular characteristics</title><title>Cancer genetics and cytogenetics</title><addtitle>Cancer Genet Cytogenet</addtitle><description>An 8;20 chromosomal translocation was observed in the leukemia cells of a 3-year-old girl. To our knowledge, this is the first report of this translocation in de novo acute leukemia. This chromosomal defect was present in the leukemia cells at diagnosis and also at relapse, but remission bone marrow cells had the 46,XX karyotype. By morphologic and cytochemical criteria the leukemia was myeloid but these features were more lymphoid when the leukemia recurred. However, the immunophenotype was consistent with myeloid leukemia and did not change at relapse. No evidence for either immunoglobulin or TCR gene rearrangement was observed.</description><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor</subject><subject>Child, Preschool</subject><subject>chromosome 20</subject><subject>chromosome 8</subject><subject>Chromosomes, Human, Pair 20</subject><subject>Chromosomes, Human, Pair 8</subject><subject>Female</subject><subject>Genetic Markers</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Immunophenotyping</subject><subject>Karyotyping</subject><subject>Leukemia, Myeloid, Acute - genetics</subject><subject>Leukemia, Myeloid, Acute - immunology</subject><subject>Leukemia, Myeloid, Acute - pathology</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Medical sciences</subject><subject>translocation</subject><subject>Translocation, Genetic - genetics</subject><issn>0165-4608</issn><issn>1873-4456</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkd9qFTEQh4Mo9Vh9A4VciCh0dZJNdjcKghxaKxS8UehdyGZnbTS7OeZP4TyCb22OPfTWizCQ-fgNMx8hzxm8ZcC6d_XJRnQwvFbsjQIQfXP9gGzY0LeNELJ7SDb3yGPyJKWfANBz1Z2QEw6gJLQb8mf4wIHamxiWkMJiPM3RrMkHa7ILK3UrNdSahDTM1NiSkXosv3Bx5j3d7nP4gStmZ8-oW5ayht0NriHvd4ef4mtWyrHYXKLxZ9SsE12CR1u8iXWoicZmjC7VgPSUPJqNT_jsWE_J94vzb9vL5urr5y_bT1cNtpzlpp_B1lW5xHGwnRr5MJl-Vn3PZ2UQ5SjbaWw74GoQHGGCFsWoGEzzPE524O0peXWXu4vhd8GU9eKSRe_NiqEkPYBQnezVf0EmleiUlBV8cQTLuOCkd9EtJu718ci1__LYN8kaP9cDW5fuMVldiU5U7OMdhnX7W4dRJ-twtTi5iDbrKTjNQB_c64NYfRCrFdP_3Ovr9i95eKKT</recordid><startdate>19910301</startdate><enddate>19910301</enddate><creator>Jorgenson, Keith F.</creator><creator>Antoun, Gamil R.</creator><creator>Childs, Craig C.</creator><creator>Felix, Edward A.</creator><creator>Cork, Ann</creator><creator>Yee, Garland</creator><creator>Trujillo, Jose M.</creator><creator>Pinkel, Donald P.</creator><creator>Zipf, Theodore F.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T3</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19910301</creationdate><title>8;20 chromosomal translocation in a case of acute leukemia: Cytogenetic, immunophenotypic, ultrastructural, and molecular characteristics</title><author>Jorgenson, Keith F. ; Antoun, Gamil R. ; Childs, Craig C. ; Felix, Edward A. ; Cork, Ann ; Yee, Garland ; Trujillo, Jose M. ; Pinkel, Donald P. ; Zipf, Theodore F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e321t-7f0c04725eb8c69b28da7f9772f9aee5b53db36029842e0d03e4b910dffbdc823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor</topic><topic>Child, Preschool</topic><topic>chromosome 20</topic><topic>chromosome 8</topic><topic>Chromosomes, Human, Pair 20</topic><topic>Chromosomes, Human, Pair 8</topic><topic>Female</topic><topic>Genetic Markers</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Immunophenotyping</topic><topic>Karyotyping</topic><topic>Leukemia, Myeloid, Acute - genetics</topic><topic>Leukemia, Myeloid, Acute - immunology</topic><topic>Leukemia, Myeloid, Acute - pathology</topic><topic>Leukemias. 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Myelofibrosis</topic><topic>Medical sciences</topic><topic>translocation</topic><topic>Translocation, Genetic - genetics</topic><toplevel>online_resources</toplevel><creatorcontrib>Jorgenson, Keith F.</creatorcontrib><creatorcontrib>Antoun, Gamil R.</creatorcontrib><creatorcontrib>Childs, Craig C.</creatorcontrib><creatorcontrib>Felix, Edward A.</creatorcontrib><creatorcontrib>Cork, Ann</creatorcontrib><creatorcontrib>Yee, Garland</creatorcontrib><creatorcontrib>Trujillo, Jose M.</creatorcontrib><creatorcontrib>Pinkel, Donald P.</creatorcontrib><creatorcontrib>Zipf, Theodore F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Human Genome Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer genetics and cytogenetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jorgenson, Keith F.</au><au>Antoun, Gamil R.</au><au>Childs, Craig C.</au><au>Felix, Edward A.</au><au>Cork, Ann</au><au>Yee, Garland</au><au>Trujillo, Jose M.</au><au>Pinkel, Donald P.</au><au>Zipf, Theodore F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>8;20 chromosomal translocation in a case of acute leukemia: Cytogenetic, immunophenotypic, ultrastructural, and molecular characteristics</atitle><jtitle>Cancer genetics and cytogenetics</jtitle><addtitle>Cancer Genet Cytogenet</addtitle><date>1991-03-01</date><risdate>1991</risdate><volume>52</volume><issue>1</issue><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>0165-4608</issn><eissn>1873-4456</eissn><coden>CGCYDF</coden><abstract>An 8;20 chromosomal translocation was observed in the leukemia cells of a 3-year-old girl. To our knowledge, this is the first report of this translocation in de novo acute leukemia. This chromosomal defect was present in the leukemia cells at diagnosis and also at relapse, but remission bone marrow cells had the 46,XX karyotype. By morphologic and cytochemical criteria the leukemia was myeloid but these features were more lymphoid when the leukemia recurred. However, the immunophenotype was consistent with myeloid leukemia and did not change at relapse. No evidence for either immunoglobulin or TCR gene rearrangement was observed.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2009503</pmid><doi>10.1016/0165-4608(91)90047-X</doi><tpages>9</tpages></addata></record> |
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| subjects | Biological and medical sciences Biomarkers, Tumor Child, Preschool chromosome 20 chromosome 8 Chromosomes, Human, Pair 20 Chromosomes, Human, Pair 8 Female Genetic Markers Hematologic and hematopoietic diseases Humans Immunophenotyping Karyotyping Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - immunology Leukemia, Myeloid, Acute - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences translocation Translocation, Genetic - genetics |
| title | 8;20 chromosomal translocation in a case of acute leukemia: Cytogenetic, immunophenotypic, ultrastructural, and molecular characteristics |
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