Basal follicle-stimulating hormone level is a better predictor of in vitro fertilization performance than age
A study of 1,478 consecutive in vitro fertilization (IVF) cycles was made to determine if basal follicle-stimulating hormone (FSH) levels and age were independent predictors of IVF performance. Regression analyses indicated independent contributions of both basal FSH and age in predicting cancellati...
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| Veröffentlicht in: | Fertility and sterility 1991-04, Vol.55 (4), p.784-791 |
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| container_title | Fertility and sterility |
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| creator | Toner, James P. Philput, Christine B. Jones, Georgeanna S. Muasher, Suheil J. |
| description | A study of 1,478 consecutive in vitro fertilization (IVF) cycles was made to determine if basal follicle-stimulating hormone (FSH) levels and age were independent predictors of IVF performance. Regression analyses indicated independent contributions of both basal FSH and age in predicting cancellation rate, peak estradiol, number of oocytes retrieved, fertilized, and transferred, and total and ongoing pregnancy rates. Miscarriage rate was unrelated to both age and basal FSH. Follicle-stimulating hormone level was a better predictor than age for all outcome variables examined and remained a significant predictor after accounting for age, etiology of infertility, and semen quality. The combined use of age and basal FSH in counseling patients improves the accuracy of prognosis, and may provide an index of functional ovarian reserve (“ovarian age”). |
| doi_str_mv | 10.1016/S0015-0282(16)54249-6 |
| format | Article |
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Regression analyses indicated independent contributions of both basal FSH and age in predicting cancellation rate, peak estradiol, number of oocytes retrieved, fertilized, and transferred, and total and ongoing pregnancy rates. Miscarriage rate was unrelated to both age and basal FSH. Follicle-stimulating hormone level was a better predictor than age for all outcome variables examined and remained a significant predictor after accounting for age, etiology of infertility, and semen quality. 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Regression analyses indicated independent contributions of both basal FSH and age in predicting cancellation rate, peak estradiol, number of oocytes retrieved, fertilized, and transferred, and total and ongoing pregnancy rates. Miscarriage rate was unrelated to both age and basal FSH. Follicle-stimulating hormone level was a better predictor than age for all outcome variables examined and remained a significant predictor after accounting for age, etiology of infertility, and semen quality. The combined use of age and basal FSH in counseling patients improves the accuracy of prognosis, and may provide an index of functional ovarian reserve (“ovarian age”).</description><subject>Abortion, Spontaneous - blood</subject><subject>Adult</subject><subject>Aging - blood</subject><subject>Biological and medical sciences</subject><subject>Birth control</subject><subject>Embryo Implantation</subject><subject>Female</subject><subject>Fertilization in Vitro</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Predictive Value of Tests</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Regression Analysis</subject><subject>Sterility. 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Andrology. Obstetrics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Predictive Value of Tests</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Regression Analysis</topic><topic>Sterility. Assisted procreation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Toner, James P.</creatorcontrib><creatorcontrib>Philput, Christine B.</creatorcontrib><creatorcontrib>Jones, Georgeanna S.</creatorcontrib><creatorcontrib>Muasher, Suheil J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Toner, James P.</au><au>Philput, Christine B.</au><au>Jones, Georgeanna S.</au><au>Muasher, Suheil J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Basal follicle-stimulating hormone level is a better predictor of in vitro fertilization performance than age</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>1991-04</date><risdate>1991</risdate><volume>55</volume><issue>4</issue><spage>784</spage><epage>791</epage><pages>784-791</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>A study of 1,478 consecutive in vitro fertilization (IVF) cycles was made to determine if basal follicle-stimulating hormone (FSH) levels and age were independent predictors of IVF performance. Regression analyses indicated independent contributions of both basal FSH and age in predicting cancellation rate, peak estradiol, number of oocytes retrieved, fertilized, and transferred, and total and ongoing pregnancy rates. Miscarriage rate was unrelated to both age and basal FSH. Follicle-stimulating hormone level was a better predictor than age for all outcome variables examined and remained a significant predictor after accounting for age, etiology of infertility, and semen quality. The combined use of age and basal FSH in counseling patients improves the accuracy of prognosis, and may provide an index of functional ovarian reserve (“ovarian age”).</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>1901282</pmid><doi>10.1016/S0015-0282(16)54249-6</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Fertility and sterility, 1991-04, Vol.55 (4), p.784-791 |
| issn | 0015-0282 1556-5653 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Abortion, Spontaneous - blood Adult Aging - blood Biological and medical sciences Birth control Embryo Implantation Female Fertilization in Vitro Follicle Stimulating Hormone - blood Gynecology. Andrology. Obstetrics Humans Medical sciences Predictive Value of Tests Pregnancy Pregnancy Outcome Regression Analysis Sterility. Assisted procreation |
| title | Basal follicle-stimulating hormone level is a better predictor of in vitro fertilization performance than age |
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