Enantioselectivity at the physiologically active GABAA receptor

A subfraction of cortical tissue from rat brain, containing membrane vesicles was prepared freshly with added protease inhibitors and antioxidant. The preparation was used to measure stimulation of transmembrane 36C1- flux and inhibition of bicuculline-sensitive [3H] muscimol binding by (+)-(S) and...

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Veröffentlicht in:	Biochemical pharmacology 1991-04, Vol.41 (8), p.1141-1144
Hauptverfasser:	Kardos, J, Kovács, I, Simon-Trompler, E, Hajós, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bicuculline - metabolism Binding, Competitive Cell Membrane - drug effects Cerebral Cortex - drug effects Chloride Channels Chlorides - physiology In Vitro Techniques Membrane Proteins - physiology Muscimol - analogs & derivatives Muscimol - metabolism Muscimol - pharmacology Oxazolidinones Rats Rats, Inbred Strains Receptors, GABA-A - drug effects Receptors, GABA-A - physiology Stereoisomerism Structure-Activity Relationship
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