Effect of Methotrexate on Glial Fibrillary Acidic Protein Content of Astrocytes in Primary Culture

We have recently reported that methotrexate (MTX) causes degenerative as well as reactive-like astroglial changes and alters the cell cycle kinetics of astrocytes in vitro. To further characterize the nature of the reactive-like changes that were noted by light and electron microscopy following MTX...

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Veröffentlicht in:	Journal of neuropathology and experimental neurology 1991-03, Vol.50 (2), p.118-125
Hauptverfasser:	Bruce-Gregoros, Jocelyn H, Soucy, David M, Chen, Melissa G, Norenberg, Michael D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Astrocytes - metabolism Astrocytes - ultrastructure Biological and medical sciences Bucladesine - pharmacology Cells, Cultured Enzyme-Linked Immunosorbent Assay Flow Cytometry Fluorescent Antibody Technique Glial Fibrillary Acidic Protein - metabolism Medical sciences Methotrexate - pharmacology Microscopy, Fluorescence Pharmacology. Drug treatments
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