Ovine Corticotropin-Releasing Factor Increases Endocrine and Immunologic Activity of Avian Leukocytes In Vitro
Abstract Treatment of splenic leukocytes from Cornell K strain male chickens (homozygous at the B 15 locus of the major histocompatibility complex) with ovine corticotropin-releasing factor (oCRF), before their co-incubation with naive chicken adrenal cells, resulted in an increase in corticosterone...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1991-04, Vol.196 (4), p.390-395 |
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| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 196 |
| creator | Hendricks, Gilbert L. Siegel, Herbert S. Mashaly, Magdi M. |
| description | Abstract
Treatment of splenic leukocytes from Cornell K strain male chickens (homozygous at the B
15 locus of the major histocompatibility complex) with ovine corticotropin-releasing factor (oCRF), before their co-incubation with naive chicken adrenal cells, resulted in an increase in corticosterone production. Supernatants from the oCRF-treated splenic leukocytes caused a time-dependent increase in corticosterone production when incubated with chicken adrenal cells. Adding oCRF directly to chicken adrenal cells did not increase corticosterone production. Pretreatment of peripheral leukocytes with oCRF increased their activity in a concanavalin A mitogen assay. Thus, chicken leukocytes stimulated with corticotropin releasing factor appear to increase the production of an “adrenocorticotropin-like” substance (adrenocorticotropin-like because it increases corticosterone production by adrenal cells), and increased their cell-mediated immune activity. |
| doi_str_mv | 10.3181/00379727-196-43204 |
| format | Article |
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Treatment of splenic leukocytes from Cornell K strain male chickens (homozygous at the B
15 locus of the major histocompatibility complex) with ovine corticotropin-releasing factor (oCRF), before their co-incubation with naive chicken adrenal cells, resulted in an increase in corticosterone production. Supernatants from the oCRF-treated splenic leukocytes caused a time-dependent increase in corticosterone production when incubated with chicken adrenal cells. Adding oCRF directly to chicken adrenal cells did not increase corticosterone production. Pretreatment of peripheral leukocytes with oCRF increased their activity in a concanavalin A mitogen assay. Thus, chicken leukocytes stimulated with corticotropin releasing factor appear to increase the production of an “adrenocorticotropin-like” substance (adrenocorticotropin-like because it increases corticosterone production by adrenal cells), and increased their cell-mediated immune activity.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>EISSN: 1525-1373</identifier><identifier>DOI: 10.3181/00379727-196-43204</identifier><identifier>PMID: 1848936</identifier><identifier>CODEN: PSEBAA</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adrenal Glands - drug effects ; Adrenal Glands - metabolism ; Adrenocorticotropic Hormone - biosynthesis ; Animals ; Biological and medical sciences ; Biological Assay ; Cell physiology ; Cell Transformation, Neoplastic - drug effects ; Chickens ; Concanavalin A - pharmacology ; Corticosterone - biosynthesis ; Corticotropin-Releasing Hormone - pharmacology ; Dose-Response Relationship, Drug ; Fundamental and applied biological sciences. Psychology ; In Vitro Techniques ; Leukocytes - immunology ; Leukocytes - metabolism ; Male ; Miscellaneous ; Molecular and cellular biology ; Regression Analysis ; Spleen - immunology ; Time Factors</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1991-04, Vol.196 (4), p.390-395</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c282t-a21dbbf85fb9a966ff0a9d6c35dec9448dfd9d39e6f42596b3a8fdd85c7ceeeb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4511224$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1848936$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hendricks, Gilbert L.</creatorcontrib><creatorcontrib>Siegel, Herbert S.</creatorcontrib><creatorcontrib>Mashaly, Magdi M.</creatorcontrib><title>Ovine Corticotropin-Releasing Factor Increases Endocrine and Immunologic Activity of Avian Leukocytes In Vitro</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Abstract
Treatment of splenic leukocytes from Cornell K strain male chickens (homozygous at the B
15 locus of the major histocompatibility complex) with ovine corticotropin-releasing factor (oCRF), before their co-incubation with naive chicken adrenal cells, resulted in an increase in corticosterone production. Supernatants from the oCRF-treated splenic leukocytes caused a time-dependent increase in corticosterone production when incubated with chicken adrenal cells. Adding oCRF directly to chicken adrenal cells did not increase corticosterone production. Pretreatment of peripheral leukocytes with oCRF increased their activity in a concanavalin A mitogen assay. Thus, chicken leukocytes stimulated with corticotropin releasing factor appear to increase the production of an “adrenocorticotropin-like” substance (adrenocorticotropin-like because it increases corticosterone production by adrenal cells), and increased their cell-mediated immune activity.</description><subject>Adrenal Glands - drug effects</subject><subject>Adrenal Glands - metabolism</subject><subject>Adrenocorticotropic Hormone - biosynthesis</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biological Assay</subject><subject>Cell physiology</subject><subject>Cell Transformation, Neoplastic - drug effects</subject><subject>Chickens</subject><subject>Concanavalin A - pharmacology</subject><subject>Corticosterone - biosynthesis</subject><subject>Corticotropin-Releasing Hormone - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>In Vitro Techniques</subject><subject>Leukocytes - immunology</subject><subject>Leukocytes - metabolism</subject><subject>Male</subject><subject>Miscellaneous</subject><subject>Molecular and cellular biology</subject><subject>Regression Analysis</subject><subject>Spleen - immunology</subject><subject>Time Factors</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><issn>1525-1373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1qGzEUhUVISNy0LxAIaBG6m0Y_MxppaUzSGgyB0HYrNPoxSmYkR5ox-O2rqZ1m19UF3e-ciz4AbjD6RjHH9wjRVrSkrbBgVU0Jqs_AAje0qSgT4hwsZqCaiSvwKecXhHDTEnYJLjGvuaBsAcLT3gcLVzGNXscxxZ0P1bPtrco-bOGj0mNMcB10Ki82w4dgok5zRAUD18MwhdjHrddwqUe_9-MBRgeXe68C3NjpNerDWGLrAH_70v4ZXDjVZ_vlNK_Br8eHn6sf1ebp-3q13FSacDJWimDTdY43rhNKMOYcUsIwTRtjtahrbpwRhgrLXE0awTqquDOGN7rV1tqOXoOvx95dim-TzaMcfNa271WwccqSo_J_3rICkiOoU8w5WSd3yQ8qHSRGcpYs3yXLIln-lVxCt6f2qRus-YgcrZb93Wmvsla9Sypon_9hdYMxIXPN_RHLamvlS5xSKE7-d_gPqPuUpQ</recordid><startdate>199104</startdate><enddate>199104</enddate><creator>Hendricks, Gilbert L.</creator><creator>Siegel, Herbert S.</creator><creator>Mashaly, Magdi M.</creator><general>SAGE Publications</general><general>Blackwell Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199104</creationdate><title>Ovine Corticotropin-Releasing Factor Increases Endocrine and Immunologic Activity of Avian Leukocytes In Vitro</title><author>Hendricks, Gilbert L. ; Siegel, Herbert S. ; Mashaly, Magdi M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c282t-a21dbbf85fb9a966ff0a9d6c35dec9448dfd9d39e6f42596b3a8fdd85c7ceeeb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adrenal Glands - drug effects</topic><topic>Adrenal Glands - metabolism</topic><topic>Adrenocorticotropic Hormone - biosynthesis</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biological Assay</topic><topic>Cell physiology</topic><topic>Cell Transformation, Neoplastic - drug effects</topic><topic>Chickens</topic><topic>Concanavalin A - pharmacology</topic><topic>Corticosterone - biosynthesis</topic><topic>Corticotropin-Releasing Hormone - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>In Vitro Techniques</topic><topic>Leukocytes - immunology</topic><topic>Leukocytes - metabolism</topic><topic>Male</topic><topic>Miscellaneous</topic><topic>Molecular and cellular biology</topic><topic>Regression Analysis</topic><topic>Spleen - immunology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hendricks, Gilbert L.</creatorcontrib><creatorcontrib>Siegel, Herbert S.</creatorcontrib><creatorcontrib>Mashaly, Magdi M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hendricks, Gilbert L.</au><au>Siegel, Herbert S.</au><au>Mashaly, Magdi M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ovine Corticotropin-Releasing Factor Increases Endocrine and Immunologic Activity of Avian Leukocytes In Vitro</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1991-04</date><risdate>1991</risdate><volume>196</volume><issue>4</issue><spage>390</spage><epage>395</epage><pages>390-395</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><eissn>1525-1373</eissn><coden>PSEBAA</coden><abstract>Abstract
Treatment of splenic leukocytes from Cornell K strain male chickens (homozygous at the B
15 locus of the major histocompatibility complex) with ovine corticotropin-releasing factor (oCRF), before their co-incubation with naive chicken adrenal cells, resulted in an increase in corticosterone production. Supernatants from the oCRF-treated splenic leukocytes caused a time-dependent increase in corticosterone production when incubated with chicken adrenal cells. Adding oCRF directly to chicken adrenal cells did not increase corticosterone production. Pretreatment of peripheral leukocytes with oCRF increased their activity in a concanavalin A mitogen assay. Thus, chicken leukocytes stimulated with corticotropin releasing factor appear to increase the production of an “adrenocorticotropin-like” substance (adrenocorticotropin-like because it increases corticosterone production by adrenal cells), and increased their cell-mediated immune activity.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>1848936</pmid><doi>10.3181/00379727-196-43204</doi><tpages>6</tpages></addata></record> |
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| ispartof | Experimental biology and medicine (Maywood, N.J.), 1991-04, Vol.196 (4), p.390-395 |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adrenal Glands - drug effects Adrenal Glands - metabolism Adrenocorticotropic Hormone - biosynthesis Animals Biological and medical sciences Biological Assay Cell physiology Cell Transformation, Neoplastic - drug effects Chickens Concanavalin A - pharmacology Corticosterone - biosynthesis Corticotropin-Releasing Hormone - pharmacology Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology In Vitro Techniques Leukocytes - immunology Leukocytes - metabolism Male Miscellaneous Molecular and cellular biology Regression Analysis Spleen - immunology Time Factors |
| title | Ovine Corticotropin-Releasing Factor Increases Endocrine and Immunologic Activity of Avian Leukocytes In Vitro |
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